ABRC

專利 Use of deoxyelephantopin (DET) and analogues thereof for reducing side effects of an anti-cancer agent. US patent issued 9173868 Shyur, L.-F.*, Chao, W.-W., and Cheng, Y.-W.
專利 Dual-functional hybrid glucanases US patent issued 9,493,751 Shyur, L.-F.* and Liu, W.-C.
專利 Novel sesquiterpene derivatives and compositions comprising the same for treating inflammation and/or neoplasm related disorders ROC patent issued I535725 Shyur, L.-F.*, Lee, K.-H., Nakagawa-Goto, K., Feng, J.-H., Chen, J.-Y., Lee, W.-L., Cheng, Y.-T., and Huang, J.-Y
專利 Galactolipids-enriched plant extracts and the uses thereof US patent issued European patent issued PRC patent issued Japan patent issued ROC patent issued US 10434132 B2 EP 2 810 651 B1 CN 104208114 B 6033255 I558403 Shyur, L.-F.*, Feng, J.-H., and Apaya, K. M.
專利 Novel sesquiterpene derivatives and their use in inflammation or cancer treatment US patent issued PCT patent issued PRC patent issued US10238631 B2 EU3151829 B1 CN107072981B Shyur, L.-F.*, Lee, K.-H., Nakagawa-Goto, K., Feng, J.-H., Chen, J.-Y., Lee, W.-L., Cheng, Y.-T., and Huang, J.-Y.
專利 Mint essential oils inhibit HRASA61L mutant keratinocyte activity and prevent skin carcinogenesis ROC patent issued US patent issued I759633 Shyur, L.-F.*, Chang, C.-T., and Chen, Y.
專利 Use of Crassocephalum rabens extract in the treatment of breast cancer. ROC patent issued US Patent pending Shyur, L.-F.*, Apaya, K. M., and Chang, M.-T.
專利 Use of Crassocephalum rabens extract in inducing humoral immune response TW patent issued Australian patent European patent South Korea I890316 AU2024222591A1 EP4665369A2 KR1020250166898A Lin, Y.-L.*, Shyur. L.-F., Lin, H.-H., Wu, Y.-S., and Chang, M.-T.
專利 Adjuvant composition comprising Crassocephalum rabens extract. US patent pending Lin, Y.-L.*, Shyur, L.-F., Lin, H.-H., and Chang, M.-T.
專利 Use of Crassocephalum rabens extract in the prevention and/or treatment of fatigue and/or depression US patent issued Shyur, L.-F., Liang, Y.-C., Chen, Y.-H., Lin, C.-J., Chang, M.-T., and Yang, C.-C.
專利 Methods of treating or preventing infectious diseases in shrimps US patent pending Shyur, L.-F., Nan, F.-H., Liao, Z.-H., Shiau, J.-Y., and Chang, M.-T.
專利 Phytogenic additive and application thereof in promoting egg production and egg quality. US patent pending Shyur, L.-F., Chen, S.-E., and Chang, M.-T.
專利 Phytogenic additive and application thereof in promoting growth and combating coccidiosis and/or necrotic enteritis ROC patent pending; USP Shyur, L.-F., Lien, Y.-Y., Cheng, M.-C., Chen, S.-E., Wang, S.-Y., Chang, M.-T., and Chang, C.-T.
專利 Phytogenic supplement and method for preventing diseases, promoting growth of poultry by using the same US patent pending Shyur, L.-F., Lien, Y.-Y., Cheng, M.-C., Cheng, Y.-B., Nguyen, M.T.T., and Chang, M.-T.
專利 Botanical supplement and method for preventing diseases, promoting growth and survival of an animal by using the same US and ROC patent pending Shyur, L.-F., Liang, Y.-C., Lin, W.-Y., Chang, C.-T., and Chang, M.-T.
論文著作 (2024) The functional role of N-link glycosylation in a novel cellobiohydrolase II (LsCel6A) from a white-rot fungus Lentinus sp. WR2 International Journal of Biological Macromolecules
論文著作 (2024) Phytocompounds from essential oil of Mentha aquatica Lime Mint prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRASQ61L keratinocyte and reprogramming macrophage activities Phytomedicine
論文著作 (2024) Trifolium pratense as a novel phytogenic supplement, is an anticoccidial agent in chickens. Poultry Science
論文著作 (2024) Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis. Phytomedicine
論文著作 (2024) Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer Molecular Oncology
論文著作 (2026) Integrated proteomics and metabolomics reveal phytosesquiterpene lactones DET and DETD-35 inhibit triple-negative breast cancer cell activity by depleting ATP synthesis and reprogramming primary metabolism Scientific Reports
論文著作 (2026) Traditional, complementary and integrative medicine: A scoping review of international standards and good practice guidelines Frontiers in Pharmacology
重要特殊獎項 (2025) 第22屆國家新創獎
重要特殊獎項 (2025) 國立臺灣海洋大學傑出校友
重要特殊獎項 (2021) 彰化精誠中學傑出校友
重要特殊獎項 (2020) 國立台灣海洋大學食品科學系傑出系友
重要特殊獎項 (2020) 國家新創精進獎
重要特殊獎項 (2020) 榮獲科技部生命科學領域最具影響力專書之一「藥用植物和真菌–研究與開發的最新進展」 (編輯委員)
重要特殊獎項 (2019) 第十六屆國家新創獎
重要特殊獎項 (2019) 國家新創精進獎
重要特殊獎項 (2018) 永信李天德卓越醫藥科技獎
重要特殊獎項 (2017) 獲得美國食品藥物管理局 (US FDA) 抗癌植物藥之新藥臨床試驗新藥 (IND, Investigational new drug)
重要特殊獎項 (2014) 國家發明創作獎
重要特殊獎項 (2013) 第十屆國家新創獎
重要特殊獎項 (2003) 年輕學者著作獎
重要特殊獎項 (2002) 百年傑出校友彰化縣溪湖國小
最新研究 (2010) Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumor growth and lung metastasis and doubles survival time in mice British Journal of Pharmacology, 159, 856-871
最新研究 (2010) Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells Journal of Proteome Research, 9, 237-253
最新研究 (2008) Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production. J. Agric. Food Chem, 56, 1567-1573
最新研究 (2006) Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell-and gene-based study Genomics
最新研究 (2006) Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator J. Ethnopharmacology
最新研究 (2005) Ethyl caffeate suppresses NF-kB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro or in mouse skin British journal of pharmacology, 146: 352-363.
PI新主頁 2026-05-13
名言 2026-05-13
中心訊息 2026-01-22 恭賀！徐麗芬特聘研究員率領之跨領域、跨單位之研究團隊榮獲「第22屆國家新創獎2025」。
論文著作 (2024) Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvant Vaccine
論文著作 (2025) Stimulation of glucose uptake by edible Pholiota nameko (T.Itô) S.Ito & S.Imai extract counteracts palmitate-induced insulin resistance in C2C12 myotubes. Frontiers in Sustainable Food Systems
論文著作 (2022) Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib resistant melanoma via GPX4 inhibition and metabolic reprogramming Pharmacological Research
論文著作 (2022) Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study metabolites
論文著作 (2022) Cellular and molecular signaling as targets for cancer vaccine therapeutics. cells
論文著作 (2023) Phytogalactolipids activate humoral immunity against colorectal cancer Journal of Experimental & Clinical Cancer Research
論文著作 (2023) miRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones Antioxidants & Redox Signaling
論文著作 (2023) Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549 Applied Biochemistry and Biotechnology
論文著作 (2023) Phytogenics in ginger, Origanum vulgare, and Syzygium aromaticum and their potential as a feed additive against Clostridium perfringens in broiler production Animals
論文著作 (2023) The critical role of galectin-12 in modulating lipid metabolism in sebaceous glands Journal of Investigative Dermatology
最新研究 (2023) 植物倍半萜內酯化合物藉由調控小分子RNA導引的粒線體功能缺失來抑制三陰性乳癌 Antioxidants & Redox Signaling, (DOI: 10.1089/ars.2021.0251)
徵才 2023-04-25 【徐麗芬研究室】誠徵研究助理/博士後研究員－植物天然藥物之研發
最新研究 (2022) 植物倍半萜內酯deoxyelephantopin (DET)和其新穎衍生物藉抑制GPX4酵素、重整代謝以及引起ferroptosis達到抑制藥性敏感或抗藥性BRAF^V600E黑色素瘤生長 Pharmacological Research, 178, 106148. (doi.org/10.1016/j.phrs.2022.106148)
論文著作 (2019) Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death Frontiers in Pharmacology
論文著作 (2019) Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity Phytomedicine
論文著作 (2019) Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib. Molecules
論文著作 (2018) Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice International Journal of Cancer
論文著作 (2018) Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1 The FEBS Journal
論文著作 (2017) Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction Scientific Reports
論文著作 (2017) Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer Phytomedicine
論文著作 (2017) Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death Oncotarget
論文著作 (2017) Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions Frontiers in Pharmacology
論文著作 (2016) Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics Pharmacology and Therapeutics
論文著作 (2016) Novel sesquiterpene lactone analogues as potent anti-breast cancer agents Molecular Oncology
論文著作 (2016) A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice MOLECULAR CANCER THERAPEUTICS
論文著作 (2016) Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy Pharmacological Research
論文著作 (2016) Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells Phytomedicine
論文著作 (2015) Structural and functional roles of glycosylation in fungal laccase from Lentinus sp PLoS ONE
論文著作 (2015) Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway Molecular Medicine
論文著作 (2015) Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice Food & Function
論文著作 (2015) New alkaloids from Formosan zoanthid Zoanthus kuroshio Tetrahedron
論文著作 (2015) Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches Evidence-based Complementary and Alternative Medicine
論文著作 (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells Journal of Leukocyte Biology
論文著作 (2013) Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms Oxidative Medicine and Cellular Longevity
論文著作 (2013) Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy Evidence-based Complementary and Alternative Medicine
論文著作 (2013) Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis Journal of Nutritional Biochemistry
論文著作 (2013) A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice PLoS ONE
論文著作 (2012) Taxol, camptothecin and beyond for cancer therapy Advances in Botanical Research
論文著作 (2012) Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice Journal of Traditional and Complementary Medicine
論文著作 (2012) Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer Breast Cancer Research and Treatment
論文著作 (2012) Engineering of dual functional hybrid glucanases Protein Engineering Design & Selection
論文著作 (2012) Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation Free Radical Biology & Medicine
論文著作 (2012) Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1 Protein Engineering Design & Selection
論文著作 (2012) Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp Environmental Science and Technology
論文著作 (2011) Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication Journal of Traditional and Complementary Medicine
論文著作 (2011) Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors Biochemical and Biophysical Research Communication
論文著作 (2011) Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo Evidence-based Complementary and Alternative Medicine
論文著作 (2011) Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection Journal of Biological Chemistry
論文著作 (2011) A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression Phytochemistry
論文著作 (2011) Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression Journal of Agricultural and Food Chemistry
論文著作 (2010) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment Malaysia patent
論文著作 (2010) Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways Phytomedicine
論文著作 (2010) Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase PROTEINS: Structure, Function, and Bioinformatics
論文著作 (2010) Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice British Journal of Pharmacology
論文著作 (2010) Current research and development of chemotherapeutic agents for melanoma Cancers
論文著作 (2010) Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells Journal of Proteome Research
論文著作 (2010) Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants Journal of Nutritional Biochemistry
論文著作 (2009) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment Australia patent issued No. AU 2003244587
論文著作 (2009) Truncated glucanase with enhanced activity and method for making the same (US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies)
論文著作 (2009) Truncated 1,3-1,4-beta- D-glucanase US patent issued No. 7,527,958
論文著作 (2009) Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
論文著作 (2009) Cancer and inflammatory disorder treatment S patent issued No. 7547455 and ROC patents pending
論文著作 (2008) Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation (US and ROC patents pending) (One technology licensing/transfer to local biotech company)
論文著作 (2008) Immunomodulatory phytocompounds and the highly efficient platform to screen the same US patent pending
論文著作 (2008) Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
論文著作 (2008) Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company)
論文著作 (2008) Metabolomics for phytomedicine research and drug development CURRENT OPINION IN CHEMICAL BIOLOGY
論文著作 (2008) Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators PHYTOCHEMISTRY
論文著作 (2008) Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells BMC Genomics
論文著作 (2008) Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production Journal of Agricultural and Food Chemistry
論文著作 (2008) A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis Cancer Research
論文著作 (2008) Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues Journal of Biomedical Science
論文著作 (2008) Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition Journal of Computer-Aided Molecular Design
論文著作 (2007) Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus Journal of Medicinal Chemistry
論文著作 (2007) Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus Journal of Medicinal Chemistry
論文著作 (2007) Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression Journal of Ethnopharmacology
論文著作 (2007) Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide Phytomedicine
論文著作 (2007) Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator Journal of Ethnopharmacology
論文著作 (2007) A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma Cancer Research
論文著作 (2007) A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7 Planta Medica
論文著作 (2006) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies (US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company)
論文著作 (2006) Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study Genomics
論文著作 (2005) The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice Journal of Biomedical Science
論文著作 (2005) Phenolic antioxidants from the heatwood of Acacia confusa Journal of Agricultural and Food Chemistry
論文著作 (2005) Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin British Journal of Pharmacology
論文著作 (2005) Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose J Mol Biol
論文著作 (2005) Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity Holzforschung
論文著作 (2005) A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2005) A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
論文著作 (2004) Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice Planta Medica
論文著作 (2004) Polyacetylenes function as anti-angiogenic agents Pharmaceutical Research
論文著作 (2004) Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa Journal of Ethnopharmacology
論文著作 (2004) Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells Journal of Biomedical Science
論文著作 (2004) Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus Journal of Biomedical Science
論文著作 (2004) Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus J. Biomed. Sci.
論文著作 (2004) Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood JOURNAL OF WOOD SCIENCE
論文著作 (2003) Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing J. Genet. Mol. Biol.
論文著作 (2003) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
論文著作 (2003) Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes JOURNAL OF MOLECULAR BIOLOGY
論文著作 (2003) Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica Journal of Agricultural and Food Chemistry
論文著作 (2002) Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata Journal of Agricultural and Food Chemistry
論文著作 (2002) Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme Biochemistry
論文著作 (2001) Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability Journal of Biological Chemistry
論文著作 (2001) Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
論文著作 (2001) Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata Holzforschung
論文著作 (2021) Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment International Journal of Molecular Sciences
論文著作 (2021) Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment Cancers
學經歷 2021-11-8 學經歷
實驗室成員 2021-11-3 實驗室成員
研究方向 2021-11-3 研究方向
論文著作 (2021) Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice International Journal of Molecular Sciences
論文著作 (2021) Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes BOTANICAL STUDIES
論文著作 (2020) Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches Journal of Experimental Botany
論文著作 (2020) Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa Plants
論文著作 (2020) Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease SCIENTIFIC REPORTS
論文著作 (2020) Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer Cancers
論文著作 (2020) White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice Food & Nutrition Research
論文著作 (2019) Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer Journal of Experimental & Clinical Cancer Research
重要發現與突破 (2018) 植物半乳糖脂dLGG 藉由負調節TNF-α介導肺血管通透性與循環oxylipin的動態平衡來抑制黑色素瘤在小鼠體內的肺轉移
重要發現與突破 (2016) 有效抑制BRAF 突變及抗標靶藥 Vemurafenib黑色素腫瘤之新穎植物倍半萜內酯衍生物
重要發現與突破 (2015) 降低膽固醇藥simvastatin與昭和草活性成分對治療動物敗血症之新穎功效與作用機制
重要發現與突破 (2012) 開發優質本土真菌漆化酵素用於生物復育及紙漿脫色
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