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論文著作 (2019)
Anti-coccidial properties and mechanisms of an edible herb, Bidens pilosa, and its active compounds for coccidiosis
Scientific Reports
論文著作 (2018)
Glatiramer acetate enhances myeloid-derived suppressor cell function via recognition of paired Ig-like receptor B
JOURNAL OF IMMUNOLOGY
論文著作 (2017)
Cytotoxic property of Streptocaulon baumii extracts and their isolated compounds against different human cancer cell lines
Philippine Science Letters
論文著作 (2017)
Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway
Oncogene
論文著作 (2016)
Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis
Scientific Reports
論文著作 (2016)
Herbal remedies for coccidiosis control: A review of plants, compounds and anticoccidial actions
Evidence-Based Complementary and Alternative Medicine
論文著作 (2016)
Field trial of medicinal plant, Bidens pilosa, against eimeriosis in broilers
Scientific reports
論文著作 (2016)
Cytopiloyne, a polyacetylenic glucoside from Bidens pilosa, acts as a novel anticandidal agent via regulation of macrophages
Journal of ethnopharmacology
論文著作 (2016)
Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARgamma pathways
Scientific reports
論文著作 (2016)
Beneficial effect of Bidens pilosa on body weight gain, food conversion ratio, gut bacteria and coccidiosis in chickens
PLoS One
論文著作 (2016)
Data on the effect of Cytopiloyne against Listeria monocytogenes infection in mice
Data in Brief
論文著作 (2015)
Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes
Evidence-based Complementary and Alternative Medicine
論文著作 (2015)
Mechanistic Study of the Phytocompound, 2-β-D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches
Evidence-based Complementary and Alternative Medicine
論文著作 (2015)
Complementary and Alternative Medicine for Diabetes 2014
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
論文著作 (2015)
Effect of Bidens pilosa on infection and drug resistance of Eimeria in chickens
Research in veterinary science
論文著作 (2015)
Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells
JOURNAL OF LEUKOCYTE BIOLOGY
論文著作 (2014)
Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle
Cellular Signalling
論文著作 (2014)
Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic Plant L
Evidence-Based Complementary and Alternative Medicine
論文著作 (2013)
Polarization and reprogramming of myeloid-derived suppressor cells
Journal of molecular cell biology
論文著作 (2013)
Natural cures for type 1 diabetes: A review of phytochemicals, Biological actions, and clinical potential
Current Medicinal Chemistry
論文著作 (2013)
Myeloid-Derived Suppressor Cells in Autoimmune Diabetes: Their Anti-diabetic Potential and Mechanism
Journal of Diabetes & Metabolism
論文著作 (2013)
Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling
BMC complementary and alternative medicine
論文著作 (2013)
Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds
Evidence-Based Complementary and Alternative Medicine
論文著作 (2013)
Complementary and alternative medicine for diabetes
Evidence-Based Complementary and Alternative Medicine
論文著作 (2013)
Botanical, Pharmacological, Phytochemical and Toxicological Aspects of the Anti-diabetic plant Bidens pilosa L
Evidence-based Complementary and Alternative Medicine
論文著作 (2013)
Bidens pilosa L. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology.
Evidence-Based Complementary and Alternative Medicine
論文著作 (2013)
Anti-diabetic effect and mode of action of cytopiloyne
Evidence-Based Complementary and Alternative Medicine
論文著作 (2012)
Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine
Cancer Immunology Immunotherapy
論文著作 (2012)
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
Journal of Biomedical Science
論文著作 (2012)
Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice
Journal of veterinary science
論文著作 (2012)
Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways
BMC complementary and alternative medicine
論文著作 (2012)
Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways
Evidence-Based Complementary and Alternative Medicine
論文著作 (2012)
Catenarin prevents type 1 diabetes in non-obese diabetic mice via inhibition of leukocyte migration involving the MEK6/p38 and MEK7/JNK pathways
Evidence-Based Complementary and Alternative Medicine
論文著作 (2011)
Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica
PloS one
論文著作 (2010)
Anti-inflammatory properties of phenolic compounds and crude extract from Phorphyra dentata
Journal of Ethnopharmacology
論文著作 (2010)
Anti-hyperglycemic properties of crude extract and triterpenes from Poria cocos
Evidence-based Complementary and Alternative Medicine
論文著作 (2010)
Suppression of cell cycle progression by Jun dimerization protein 2 (JDP2) involves down-regulation of cyclin A2
ONCOGENE
論文著作 (2010)
Myeloid-derived suppressor cells prevent type 1 diabetes in murine models
JOURNAL OF IMMUNOLOGY
論文著作 (2009)
Role of Cybr, a cytohesin binder and regulator, in CD4+ T-cell function and host immunity
MOLECULAR IMMUNOLOGY
論文著作 (2009)
Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract
Journal of Ethnopharmacology
論文著作 (2009)
Anti-diabetic properties of three common Bidens pilosa variants in Taiwan
PHYTOCHEMISTRY
論文著作 (2007)
咸豐草的功效
科學發展
論文著作 (2007)
The effect of centaurein on interferon gamma expression and Listeria infection in mice
TOXICOLOGY AND APPLIED PHARMACOLOGY
論文著作 (2007)
Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-g expression
Journal of Ethnopharmacology
論文著作 (2007)
Cytopiloyne, a Polyacetylenic Glucoside, Prevents Type 1 Diabetes in Non-obese Diabetic Mice
JOURNAL OF IMMUNOLOGY
論文著作 (2007)
Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator
Journal of Ethnopharmacology
論文著作 (2006)
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based study
Genomics
論文著作 (2005)
The distinct effect of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice J Biomed Sci
Journal of Biomedical Science
論文著作 (2004)
The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule
EUROPEAN JOURNAL OF IMMUNOLOGY
論文著作 (2004)
Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice
Planta Medica
論文著作 (2001)
Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain
JOURNAL OF IMMUNOLOGY
論文著作 (2000)
Tec kinases: a family with multiple roles in immunity
IMMUNITY
論文著作 (2000)
Role of Tec kinase in nuclear factor of activated T cells signaling
INTERNATIONAL IMMUNOLOGY
論文著作 (1999)
The role of Tec protein-tyrosine kinase in T cell signaling
Journal of Biological Chemistry
論文著作 (1999)
Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway
EUROPEAN JOURNAL OF IMMUNOLOGY
重要特殊獎項 (2021)
國家農業科學獎
重要發現與突破 (2021)
蛋白雙硫異構酶(Pdia4)負責調控胰島細胞衰竭和糖尿病
論文著作 (2021)
On-Site Diagnosis of Poultry Coccidiosis by a Miniature Mass Spectrometer and Machine Learning
ACS Agricultural Science & Technology
中心訊息 2021-12-16
農業生物科技研究中心楊文欽團隊榮獲國家農業科學獎

論文著作 (2021)
Functional and Mechanistic Studies of Two Anti-coccidial Herbs, Bidens pilosa and Artemisia indica
Planta Medica
論文著作 (2021)
Protein disulfide isomerase a4 promotes lung cancer development via the Stat3 pathway in stromal cells Clinical and Translational Medicine
Clinical and Translational Medicine
論文著作 (2021)
Glutamatergic Neurons Differentiated from Embryonic Stem Cells: An Investigation of Differentiation and Associated Diseases
International Journal of Molecular Sciences
論文著作 (2021)
Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach
Frontiers in Endocrinology
論文著作 (2021)
Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling
International Journal of Molecular Sciences
論文著作 (2021)
Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy
EMBO Molecular Medicine
論文著作 (2021)
Sesamol Ameliorates Renal Injury-Mediated Atherosclerosis via Inhibition of Oxidative Stress/IKKα/p53
Antioxidants
論文著作 (2020)
Bidens pilosa: Nutritional Value and Benefits for Metabolic Syndrome
eFood
論文著作 (2020)
Authentication, phytochemical characterization and anti-bacterial activity of twoArtemisiaspecies
Food Chemistry
論文著作 (2020)
Toxicity study of Bidens pilosa in animals
Journal of Traditional and Complementary Medicine
論文著作 (2020)
Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential
Pharmacological Research
論文著作 (2019)
Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons
Journal of Agricultural and Food Chemistry
重要發現與突破 (2020)
糖尿病市場首見藥PS1開發
重要發現與突破 (2018)
糖尿病植物藥開發
重要發現與突破 (2017)
多功能蛋白Pdia4透過抑制細胞凋亡導致腫瘤生長
重要發現與突破 (2015)
研發抗雞隻球蟲咸豐草配方
重要發現與突破 (2013)
Cytopiloyne治療糖尿病的潛力與機制
重要發現與突破 (2010)
骨髓衍生免疫抑制細胞可以預防第一型糖尿病
重要發現與突破 (2006)
預防第一型糖尿病的聚乙炔類 (CP)
重要特殊獎項 (2020-09-24)
2020未來科技獎
重要特殊獎項 (2019)
2019台灣創新博覽會創新發明獎
重要特殊獎項 (2019)
國家新創獎
重要特殊獎項 (2018-12)
Lecture Award of Asia-Pacific Association of Agricultural Research Institutions (APAARI)
重要特殊獎項 (2018-12)
Outstanding Poster Award of APAARI
重要特殊獎項 (2018-09)
2018年台灣創新技術博覽會科技部展區重點技術
重要特殊獎項 (2018-09)
中華天然藥物學會論文獎
重要特殊獎項 (2017)
中華民國雜草學會 優良壁報論文獎
重要特殊獎項 (2016(8))
2016年美洲華人生物學科學會(SCBA)最佳壁報論文獎
重要特殊獎項 (2015-06)
2015年美洲華人生物學科學會(SCBA)最佳壁報論文獎
重要特殊獎項 (2015)
台灣生醫暨新農業產業選秀大賽新農組潛力新秀獎
重要特殊獎項 (2013-11)
第11屆國家新創獎
重要特殊獎項 (2013-10)
經濟部智財局國家發明創作獎
重要特殊獎項 (2012-11)
International Inventor prize (國際發明家學術國光獎章)
重要特殊獎項 (2010-2018)
科技部獎勵特殊優秀人才
重要特殊獎項 (2010-01)
中研院前瞻計畫(2010 Career Development Award of Academia Sinica)
重要特殊獎項 (2008-08)
第六屆國家新創獎
重要特殊獎項 (2007-02)
白蘭氏第四屆(2007)健康百萬論文獎優良論文指導教授
專利
用於腫瘤診斷及治療之多炔糖?衍生物的標靶PDIA4
Taiwan I570411
楊文欽
專利
Pdia4, target of cytopiloyne derivatives, for tumor diagnosis and treatment
USA-regular US9382330B2
楊文欽
專利
治療糖尿病之組合物
Taiwan I522108
楊文欽
專利
Anti-coccidial prevention and treatment of Bidens pilosa and its phytochemicals
PCT, USA-regular US 9072312B2
楊文欽,張力天
專利
咸豐草與其化合物預防與治療球蟲感染 Anti-coccidial prevention and treatment of Bidens pilosa and its phytochemicals
Taiwan TW I 465242
楊文欽,張力天
專利
抑制白血球之CXC趨化素受器4型之虎丈萃取物及其製造方法
Taiwan TWI 422383
楊文欽,楊緒信,林雅俐,ClementMettling
專利
Polyacetylenic compounds
EP EP2384758 B1
楊文欽,張力天
專利
polyacetylenic compounds for protecting against pancreatic islet atrophy polyacetylenic compounds for protecting against pancreatic islet atrophy
USA-regular US8575116 B1
楊文欽
專利
用於防止胰島萎縮症之聚炔類化合物
Taiwan TWI 412508
楊文欽
專利
POLYACETYLENIC COMPOUNDS FOR PROTECTING AGAINST PANCREATIC ISLET ATROPHY
USA-regular US 8536141
楊文欽
專利
免疫調節之組合物
Taiwan TW I 377347
楊文欽,張書林,江一民,徐麗芬
專利
利用centaurein預防或治瘵胞內菌感染
Taiwan TW I 373341
楊文欽
專利
聚炔類化合物
Taiwan TWI 370738
楊文欽
專利
免疫調節之組合物
Taiwan TW I 369497
楊文欽,張書林,江一民,徐麗芬
專利
POLYACETYLENIC COMPOUNDS FOR STIMULATING INSULIN GENE EXRESSION, PRODUCTION AND SECRETION
USA-regular US 8147880 B2
楊文欽
專利
BUTANOL EXTRACT OF BIDENS PILOSA
USA-regular US 8048860
徐麗芬,江一民,張書林,張力天,楊文欽
專利
Polyacetylenic compounds
EP EP1955701
楊文欽
專利
咸豐草之正丁醇萃取物
Taiwan TW I 347191
楊文欽,張書林,徐麗芬,江一民,張力天
專利
Polyacetylenic compounds
USA-regular US7763285B2
楊文欽
專利
Immunomodulatory Compositions
USA-regular 7691575
楊文欽,張書林,江一民,徐麗芬
專利
Antibacterial Treatment and Composition
USA-regular 7341752
楊文欽
最新研究 (2021)
繼發現胰島素百年後的新突破? 蛋白雙硫異構酶(Pdia4)負責調控胰島細胞衰竭和糖尿病
EMBO Molecular Medicine, e11668

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中心訊息 (1)
最新研究 (1)
專利 (21)
論文著作 (68)
重要發現與突破 (8)
重要特殊獎項 (19)
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