Phytocompounds from essential oil of Mentha aquatica Lime Mint prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRASQ61L keratinocyte and reprogramming macrophage activities Phytomedicine
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Cellular and molecular signaling as targets for cancer vaccine therapeutics. cells
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Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study metabolites
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Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib resistant melanoma via GPX4 inhibition and metabolic reprogramming Pharmacological Research
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The critical role of galectin-12 in modulating lipid metabolism in sebaceous glands Journal of Investigative Dermatology
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Phytogenics in ginger, Origanum vulgare, and Syzygium aromaticum and their potential as a feed additive against Clostridium perfringens in broiler production Animals
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Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549 Applied Biochemistry and Biotechnology
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miRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones Antioxidants & Redox Signaling
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Phytogalactolipids activate humoral immunity against colorectal cancer Journal of Experimental & Clinical Cancer Research
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Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvant Vaccine
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Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer Molecular Oncology
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Trifolium pratense as a novel phytogenic supplement, is an anticoccidial agent in chickens Poultry Science
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Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death Frontiers in Pharmacology
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Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity Phytomedicine
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Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib. Molecules
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Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice International Journal of Cancer
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Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1 The FEBS Journal
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Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction Scientific Reports
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Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer Phytomedicine
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Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death Oncotarget
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Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions Frontiers in Pharmacology
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Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics Pharmacology and Therapeutics
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Novel sesquiterpene lactone analogues as potent anti-breast cancer agents Molecular Oncology
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A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice MOLECULAR CANCER THERAPEUTICS
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Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy Pharmacological Research
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Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells Phytomedicine
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Structural and functional roles of glycosylation in fungal laccase from Lentinus sp PLoS ONE
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Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway Molecular Medicine
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Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice Food & Function
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New alkaloids from Formosan zoanthid Zoanthus kuroshio Tetrahedron
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Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches Evidence-based Complementary and Alternative Medicine
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Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells Journal of Leukocyte Biology
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Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms Oxidative Medicine and Cellular Longevity
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Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy Evidence-based Complementary and Alternative Medicine
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Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis Journal of Nutritional Biochemistry
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A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice PLoS ONE
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Taxol, camptothecin and beyond for cancer therapy Advances in Botanical Research
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Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice Journal of Traditional and Complementary Medicine
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Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer Breast Cancer Research and Treatment
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Engineering of dual functional hybrid glucanases Protein Engineering Design & Selection
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Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation Free Radical Biology & Medicine
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Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1 Protein Engineering Design & Selection
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Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp Environmental Science and Technology
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Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication Journal of Traditional and Complementary Medicine
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Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors Biochemical and Biophysical Research Communication
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Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo Evidence-based Complementary and Alternative Medicine
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Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection Journal of Biological Chemistry
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A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression Phytochemistry
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Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression Journal of Agricultural and Food Chemistry
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Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment Malaysia patent
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Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways Phytomedicine
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Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase PROTEINS: Structure, Function, and Bioinformatics
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Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice British Journal of Pharmacology
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Current research and development of chemotherapeutic agents for melanoma Cancers
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Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells Journal of Proteome Research
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Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants Journal of Nutritional Biochemistry
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Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment PRC patent issued No. CN ZL03158682. 1
論文著作 (2009)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment Australia patent issued No. AU 2003244587
論文著作 (2009)
Truncated glucanase with enhanced activity and method for making the same (US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies)
論文著作 (2009)
Truncated 1,3-1,4-beta- D-glucanase US patent issued No. 7,527,958
論文著作 (2009)
Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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Cancer and inflammatory disorder treatment S patent issued No. 7547455 and ROC patents pending
論文著作 (2008)
Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation (US and ROC patents pending) (One technology licensing/transfer to local biotech company)
論文著作 (2008)
Immunomodulatory phytocompounds and the highly efficient platform to screen the same US patent pending
論文著作 (2008)
Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
論文著作 (2008)
Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company)
論文著作 (2008)
Metabolomics for phytomedicine research and drug development CURRENT OPINION IN CHEMICAL BIOLOGY
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Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators PHYTOCHEMISTRY
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Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells BMC Genomics
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Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production Journal of Agricultural and Food Chemistry
論文著作 (2008)
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis Cancer Research
論文著作 (2008)
Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues Journal of Biomedical Science
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Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition Journal of Computer-Aided Molecular Design
論文著作 (2007)
Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus Journal of Medicinal Chemistry
論文著作 (2007)
Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus Journal of Medicinal Chemistry
論文著作 (2007)
Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression Journal of Ethnopharmacology
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Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide Phytomedicine
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Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator Journal of Ethnopharmacology
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A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma Cancer Research
論文著作 (2007)
A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7 Planta Medica
論文著作 (2006)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies (US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company)
論文著作 (2006)
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study Genomics
論文著作 (2005)
The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice Journal of Biomedical Science
論文著作 (2005)
The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice Journal of Biomedical Science
論文著作 (2005)
The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice Journal of Biomedical Science
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Phenolic antioxidants from the heatwood of Acacia confusa Journal of Agricultural and Food Chemistry
論文著作 (2005)
Phenolic Antioxidants From the Heartwood of Acacia confusa Journal of Agricultural and Food Chemistry
論文著作 (2005)
Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin British Journal of Pharmacology
論文著作 (2005)
Ethyl caffeate suppress NF B activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro or in mouse skin British Journal of Pharmacology
論文著作 (2005)
Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose J Mol Biol
論文著作 (2005)
Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-1-D-glucanase in complex with -1,3-1,4-cellotriose J. Mol. Biol.
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Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity Holzforschung
論文著作 (2005)
Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity Holzforschung
論文著作 (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2005)
A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2004)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
論文著作 (2004)
Shikonin, hytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor Journal of Biological Chemistry
論文著作 (2004)
Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice Planta Medica
論文著作 (2004)
Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice Planta Medica
論文著作 (2004)
Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice Planta Medica
論文著作 (2004)
Polyacetylenes function as anti-angiogenic agents PHARMACOLOGICAL RESEARCH
論文著作 (2004)
Polyacetylenes function as anti-angiogenic agents Pharmaceutical Research
論文著作 (2004)
Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa Journal of Ethnopharmacology
論文著作 (2004)
Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa Journal of Ethnopharmacology
論文著作 (2004)
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells Journal of Biomedical Science
論文著作 (2004)
Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus Journal of Biomedical Science
論文著作 (2004)
Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus J. Biomed. Sci.
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Antioxidant activity of extracts from Calocedrus formosana leaf, bark and heartwood Journal of Wood Science
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Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood JOURNAL OF WOOD SCIENCE
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Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing J. Genet. Mol. Biol.
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Tissue array transgene expression system for the evaluation of effect of medicinal herbs on wound-healing J Genet Mol Biol
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Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
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Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes JOURNAL OF MOLECULAR BIOLOGY
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Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica Journal of Agricultural and Food Chemistry
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Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata Journal of Agricultural and Food Chemistry
論文著作 (2002)
Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme Biochemistry
論文著作 (2001)
Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability Journal of Biological Chemistry
論文著作 (2001)
Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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Antioxidant activity of extracts from Acacia confusa bark and heartwood Journal of Agricultural and Food Chemistry
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Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata Holzforschung
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Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment Cancers
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Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment International Journal of Molecular Sciences
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Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice International Journal of Molecular Sciences
論文著作 (2021)
Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes BOTANICAL STUDIES
論文著作 (2020)
White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice Food & Nutrition Research
論文著作 (2020)
Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa Plants
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Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches Journal of Experimental Botany
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Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer Cancers
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Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease SCIENTIFIC REPORTS
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Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer Journal of Experimental & Clinical Cancer Research
