Phytocompounds from essential oil of Mentha aquatica L. cv. Lime prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRAS keratinocytes and reprogramming macrophage activities Phytomedicine
論文著作 (2023)
The critical role of galectin-12 in modulating lipid metabolism in sebaceous glands. Journal of Investigative Dermatology
論文著作 (2023)
Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549. Applied Biochemistry and Biotechnology
論文著作 (2023)
Phytogalactolipids activate humoral immunity against colorectal cancer Journal of Experimental & Clinical Cancer Research
論文著作 (2022)
Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics Cells
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MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones ANTIOXIDANTS & REDOX SIGNALING
論文著作 (2022)
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming Pharmacological Research
論文著作 (2019)
Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death Frontiers in Pharmacology
論文著作 (2019)
Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity Phytomedicine
論文著作 (2019)
Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib. Molecules
論文著作 (2018)
Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice International Journal of Cancer
論文著作 (2018)
Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1 The FEBS Journal
論文著作 (2017)
Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction Scientific Reports
論文著作 (2017)
Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer Phytomedicine
論文著作 (2017)
Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death Oncotarget
論文著作 (2017)
Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions Frontiers in Pharmacology
論文著作 (2016)
Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics Pharmacology and Therapeutics
論文著作 (2016)
Novel sesquiterpene lactone analogues as potent anti-breast cancer agents Molecular Oncology
論文著作 (2016)
A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice MOLECULAR CANCER THERAPEUTICS
論文著作 (2016)
Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy Pharmacological Research
論文著作 (2016)
Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells Phytomedicine
論文著作 (2015)
Structural and functional roles of glycosylation in fungal laccase from Lentinus sp PLoS ONE
論文著作 (2015)
Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway Molecular Medicine
論文著作 (2015)
Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice Food & Function
論文著作 (2015)
New alkaloids from Formosan zoanthid Zoanthus kuroshio Tetrahedron
論文著作 (2015)
Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches Evidence-based Complementary and Alternative Medicine
論文著作 (2015)
Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells Journal of Leukocyte Biology
論文著作 (2013)
Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms Oxidative Medicine and Cellular Longevity
論文著作 (2013)
Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy Evidence-based Complementary and Alternative Medicine
論文著作 (2013)
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis Journal of Nutritional Biochemistry
論文著作 (2013)
A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice PLoS ONE
論文著作 (2012)
Taxol, camptothecin and beyond for cancer therapy Advances in Botanical Research
論文著作 (2012)
Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice Journal of Traditional and Complementary Medicine
論文著作 (2012)
Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer Breast Cancer Research and Treatment
論文著作 (2012)
Engineering of dual functional hybrid glucanases Protein Engineering Design & Selection
論文著作 (2012)
Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation Free Radical Biology & Medicine
論文著作 (2012)
Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1 Protein Engineering Design & Selection
論文著作 (2012)
Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp Environmental Science and Technology
論文著作 (2011)
Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication Journal of Traditional and Complementary Medicine
論文著作 (2011)
Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors Biochemical and Biophysical Research Communication
論文著作 (2011)
Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo Evidence-based Complementary and Alternative Medicine
論文著作 (2011)
Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection Journal of Biological Chemistry
論文著作 (2011)
A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression Phytochemistry
論文著作 (2011)
Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression Journal of Agricultural and Food Chemistry
論文著作 (2010)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment Malaysia patent
論文著作 (2010)
Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways Phytomedicine
論文著作 (2010)
Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase PROTEINS: Structure, Function, and Bioinformatics
論文著作 (2010)
Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice British Journal of Pharmacology
論文著作 (2010)
Current research and development of chemotherapeutic agents for melanoma Cancers
論文著作 (2010)
Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells Journal of Proteome Research
論文著作 (2010)
Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants Journal of Nutritional Biochemistry
論文著作 (2009)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment PRC patent issued No. CN ZL03158682. 1
論文著作 (2009)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment Australia patent issued No. AU 2003244587
論文著作 (2009)
Truncated glucanase with enhanced activity and method for making the same (US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies)
論文著作 (2009)
Truncated 1,3-1,4-beta- D-glucanase US patent issued No. 7,527,958
論文著作 (2009)
Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
論文著作 (2009)
Cancer and inflammatory disorder treatment S patent issued No. 7547455 and ROC patents pending
論文著作 (2008)
Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation (US and ROC patents pending) (One technology licensing/transfer to local biotech company)
論文著作 (2008)
Immunomodulatory phytocompounds and the highly efficient platform to screen the same US patent pending
論文著作 (2008)
Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
論文著作 (2008)
Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company)
論文著作 (2008)
Metabolomics for phytomedicine research and drug development CURRENT OPINION IN CHEMICAL BIOLOGY
論文著作 (2008)
Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators PHYTOCHEMISTRY
論文著作 (2008)
Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells BMC Genomics
論文著作 (2008)
Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production Journal of Agricultural and Food Chemistry
論文著作 (2008)
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis Cancer Research
論文著作 (2008)
Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues Journal of Biomedical Science
論文著作 (2008)
Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition Journal of Computer-Aided Molecular Design
論文著作 (2007)
Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus Journal of Medicinal Chemistry
論文著作 (2007)
Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus Journal of Medicinal Chemistry
論文著作 (2007)
Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression Journal of Ethnopharmacology
論文著作 (2007)
Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide Phytomedicine
論文著作 (2007)
Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator Journal of Ethnopharmacology
論文著作 (2007)
A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma Cancer Research
論文著作 (2007)
A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7 Planta Medica
論文著作 (2006)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies (US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company)
論文著作 (2006)
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study Genomics
論文著作 (2005)
The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice Journal of Biomedical Science
論文著作 (2005)
The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice Journal of Biomedical Science
論文著作 (2005)
The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice Journal of Biomedical Science
論文著作 (2005)
Phenolic antioxidants from the heatwood of Acacia confusa Journal of Agricultural and Food Chemistry
論文著作 (2005)
Phenolic Antioxidants From the Heartwood of Acacia confusa Journal of Agricultural and Food Chemistry
論文著作 (2005)
Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin British Journal of Pharmacology
論文著作 (2005)
Ethyl caffeate suppress NF B activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro or in mouse skin British Journal of Pharmacology
論文著作 (2005)
Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose J Mol Biol
論文著作 (2005)
Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-1-D-glucanase in complex with -1,3-1,4-cellotriose J. Mol. Biol.
論文著作 (2005)
Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity Holzforschung
論文著作 (2005)
Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity Holzforschung
論文著作 (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2005)
A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2004)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
論文著作 (2004)
Shikonin, hytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor Journal of Biological Chemistry
論文著作 (2004)
Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice Planta Medica
論文著作 (2004)
Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice Planta Medica
論文著作 (2004)
Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice Planta Medica
論文著作 (2004)
Polyacetylenes function as anti-angiogenic agents PHARMACOLOGICAL RESEARCH
論文著作 (2004)
Polyacetylenes function as anti-angiogenic agents Pharmaceutical Research
論文著作 (2004)
Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa Journal of Ethnopharmacology
論文著作 (2004)
Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa Journal of Ethnopharmacology
論文著作 (2004)
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells Journal of Biomedical Science
論文著作 (2004)
Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus Journal of Biomedical Science
論文著作 (2004)
Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus J. Biomed. Sci.
論文著作 (2004)
Antioxidant activity of extracts from Calocedrus formosana leaf, bark and heartwood Journal of Wood Science
論文著作 (2004)
Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood JOURNAL OF WOOD SCIENCE
論文著作 (2003)
Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing J. Genet. Mol. Biol.
論文著作 (2003)
Tissue array transgene expression system for the evaluation of effect of medicinal herbs on wound-healing J Genet Mol Biol
論文著作 (2003)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
論文著作 (2003)
Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes JOURNAL OF MOLECULAR BIOLOGY
論文著作 (2003)
Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica Journal of Agricultural and Food Chemistry
論文著作 (2002)
Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata Journal of Agricultural and Food Chemistry
論文著作 (2002)
Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme Biochemistry
論文著作 (2001)
Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability Journal of Biological Chemistry
論文著作 (2001)
Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
論文著作 (2001)
Antioxidant activity of extracts from Acacia confusa bark and heartwood Journal of Agricultural and Food Chemistry
論文著作 (2001)
Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata Holzforschung
論文著作 (2021)
Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment Cancers
論文著作 (2021)
Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment International Journal of Molecular Sciences
論文著作 (2021)
Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice International Journal of Molecular Sciences
論文著作 (2021)
Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes BOTANICAL STUDIES
論文著作 (2020)
White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice Food & Nutrition Research
論文著作 (2020)
Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa Plants
論文著作 (2020)
Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches Journal of Experimental Botany
論文著作 (2020)
Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer Cancers
論文著作 (2020)
Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease SCIENTIFIC REPORTS
論文著作 (2019)
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer Journal of Experimental & Clinical Cancer Research
