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Published Papers

Published Papers (2022)
Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics
Cells
Published Papers (2022)
MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones
ANTIOXIDANTS & REDOX SIGNALING
Published Papers (2022)
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming
Pharmacological Research
Published Papers (2019)
Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death
Frontiers in Pharmacology
Published Papers (2019)
Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity
Phytomedicine
Published Papers (2019)
Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib.
Molecules
Published Papers (2018)
Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice
International Journal of Cancer
Published Papers (2018)
Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1
The FEBS Journal
Published Papers (2017)
Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction
Scientific Reports
Published Papers (2017)
Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer
Phytomedicine
Published Papers (2017)
Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death
Oncotarget
Published Papers (2017)
Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions
Frontiers in Pharmacology
Published Papers (2016)
Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics
Pharmacology and Therapeutics
Published Papers (2016)
Novel sesquiterpene lactone analogues as potent anti-breast cancer agents
Molecular Oncology
Published Papers (2016)
A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice
MOLECULAR CANCER THERAPEUTICS
Published Papers (2016)
Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy
Pharmacological Research
Published Papers (2016)
Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells
Phytomedicine
Published Papers (2015)
Structural and functional roles of glycosylation in fungal laccase from Lentinus sp
PLoS ONE
Published Papers (2015)
Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway
Molecular Medicine
Published Papers (2015)
Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice
Food & Function
Published Papers (2015)
New alkaloids from Formosan zoanthid Zoanthus kuroshio
Tetrahedron
Published Papers (2015)
Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches
Evidence-based Complementary and Alternative Medicine
Published Papers (2015)
Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells
Journal of Leukocyte Biology
Published Papers (2013)
Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms
Oxidative Medicine and Cellular Longevity
Published Papers (2013)
Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy
Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis
Journal of Nutritional Biochemistry
Published Papers (2013)
A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice
PLoS ONE
Published Papers (2012)
Taxol, camptothecin and beyond for cancer therapy
Advances in Botanical Research
Published Papers (2012)
Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice
Journal of Traditional and Complementary Medicine
Published Papers (2012)
Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer
Breast Cancer Research and Treatment
Published Papers (2012)
Engineering of dual functional hybrid glucanases
Protein Engineering Design & Selection
Published Papers (2012)
Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation
Free Radical Biology & Medicine
Published Papers (2012)
Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1
Protein Engineering Design & Selection
Published Papers (2012)
Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp
Environmental Science and Technology
Published Papers (2011)
Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication
Journal of Traditional and Complementary Medicine
Published Papers (2011)
Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors
Biochemical and Biophysical Research Communication
Published Papers (2011)
Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo
Evidence-based Complementary and Alternative Medicine
Published Papers (2011)
Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection
Journal of Biological Chemistry
Published Papers (2011)
A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression
Phytochemistry
Published Papers (2011)
Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression
Journal of Agricultural and Food Chemistry
Published Papers (2010)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment
Malaysia patent
Published Papers (2010)
Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways
Phytomedicine
Published Papers (2010)
Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase
PROTEINS: Structure, Function, and Bioinformatics
Published Papers (2010)
Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice
British Journal of Pharmacology
Published Papers (2010)
Current research and development of chemotherapeutic agents for melanoma
Cancers
Published Papers (2010)
Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells
Journal of Proteome Research
Published Papers (2010)
Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants
Journal of Nutritional Biochemistry
Published Papers (2009)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment
PRC patent issued No. CN ZL03158682. 1
Published Papers (2009)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment
Australia patent issued No. AU 2003244587
Published Papers (2009)
Truncated glucanase with enhanced activity and method for making the same
(US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies)
Published Papers (2009)
Truncated 1,3-1,4-beta- D-glucanase
US patent issued No. 7,527,958
Published Papers (2009)
Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Published Papers (2009)
Cancer and inflammatory disorder treatment
S patent issued No. 7547455 and ROC patents pending
Published Papers (2008)
Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation
(US and ROC patents pending) (One technology licensing/transfer to local biotech company)
Published Papers (2008)
Immunomodulatory phytocompounds and the highly efficient platform to screen the same
US patent pending
Published Papers (2008)
Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Published Papers (2008)
Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea
(US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company)
Published Papers (2008)
Metabolomics for phytomedicine research and drug development
CURRENT OPINION IN CHEMICAL BIOLOGY
Published Papers (2008)
Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators
PHYTOCHEMISTRY
Published Papers (2008)
Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells
BMC Genomics
Published Papers (2008)
Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production
Journal of Agricultural and Food Chemistry
Published Papers (2008)
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis
Cancer Research
Published Papers (2008)
Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues
Journal of Biomedical Science
Published Papers (2008)
Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition
Journal of Computer-Aided Molecular Design
Published Papers (2007)
Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus
Journal of Medicinal Chemistry
Published Papers (2007)
Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus
Journal of Medicinal Chemistry
Published Papers (2007)
Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression
Journal of Ethnopharmacology
Published Papers (2007)
Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide
Phytomedicine
Published Papers (2007)
Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator
Journal of Ethnopharmacology
Published Papers (2007)
A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma
Cancer Research
Published Papers (2007)
A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7
Planta Medica
Published Papers (2006)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies
(US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company)
Published Papers (2006)
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study
Genomics
Published Papers (2005)
The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice
Journal of Biomedical Science
Published Papers (2005)
The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice
Journal of Biomedical Science
Published Papers (2005)
The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice
Journal of Biomedical Science
Published Papers (2005)
Phenolic antioxidants from the heatwood of Acacia confusa
Journal of Agricultural and Food Chemistry
Published Papers (2005)
Phenolic Antioxidants From the Heartwood of Acacia confusa
Journal of Agricultural and Food Chemistry
Published Papers (2005)
Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin
British Journal of Pharmacology
Published Papers (2005)
Ethyl caffeate suppress NF B activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro or in mouse skin
British Journal of Pharmacology
Published Papers (2005)
Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose
J Mol Biol
Published Papers (2005)
Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-1-D-glucanase in complex with -1,3-1,4-cellotriose
J. Mol. Biol.
Published Papers (2005)
Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity
Holzforschung
Published Papers (2005)
Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity
Holzforschung
Published Papers (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance
Biochemistry
Published Papers (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance
Biochemistry
Published Papers (2005)
A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance
Biochemistry
Published Papers (2004)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo
Journal of Biological Chemistry
Published Papers (2004)
Shikonin, hytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor
Journal of Biological Chemistry
Published Papers (2004)
Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice
Planta Medica
Published Papers (2004)
Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice
Planta Medica
Published Papers (2004)
Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice
Planta Medica
Published Papers (2004)
Polyacetylenes function as anti-angiogenic agents
PHARMACOLOGICAL RESEARCH
Published Papers (2004)
Polyacetylenes function as anti-angiogenic agents
Pharmaceutical Research
Published Papers (2004)
Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa
Journal of Ethnopharmacology
Published Papers (2004)
Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa
Journal of Ethnopharmacology
Published Papers (2004)
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells
Journal of Biomedical Science
Published Papers (2004)
Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus
Journal of Biomedical Science
Published Papers (2004)
Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus
J. Biomed. Sci.
Published Papers (2004)
Antioxidant activity of extracts from Calocedrus formosana leaf, bark and heartwood
Journal of Wood Science
Published Papers (2004)
Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood
JOURNAL OF WOOD SCIENCE
Published Papers (2003)
Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing
J. Genet. Mol. Biol.
Published Papers (2003)
Tissue array transgene expression system for the evaluation of effect of medicinal herbs on wound-healing
J Genet Mol Biol
Published Papers (2003)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo
Journal of Biological Chemistry
Published Papers (2003)
Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes
JOURNAL OF MOLECULAR BIOLOGY
Published Papers (2003)
Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica
Journal of Agricultural and Food Chemistry
Published Papers (2002)
Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata
Journal of Agricultural and Food Chemistry
Published Papers (2002)
Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme
Biochemistry
Published Papers (2001)
Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability
Journal of Biological Chemistry
Published Papers (2001)
Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Published Papers (2001)
Antioxidant activity of extracts from Acacia confusa bark and heartwood
Journal of Agricultural and Food Chemistry
Published Papers (2001)
Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata
Holzforschung
Published Papers (2021)
Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment
Cancers
Published Papers (2021)
Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment
International Journal of Molecular Sciences
Published Papers (2021)
Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice
International Journal of Molecular Sciences
Published Papers (2021)
Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes
BOTANICAL STUDIES
Published Papers (2020)
White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice
Food & Nutrition Research
Published Papers (2020)
Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa
Plants
Published Papers (2020)
Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches
Journal of Experimental Botany
Published Papers (2020)
Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer
Cancers
Published Papers (2020)
Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease
SCIENTIFIC REPORTS
Published Papers (2019)
Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer
Journal of Experimental & Clinical Cancer Research
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