論文著作
| 論文著作 (2026) Integrated proteomics and metabolomics reveal phytosesquiterpene lactones DET and DETD-35 inhibit triple-negative breast cancer cell activity by depleting ATP synthesis and reprogramming primary metabolism 更多 Scientific Reports | |
| 論文著作 (2026) Traditional, complementary and integrative medicine: A scoping review of international standards and good practice guidelines 更多 Frontiers in Pharmacology | |
| 論文著作 (2025) Stimulation of glucose uptake by edible Pholiota nameko (T.Itô) S.Ito & S.Imai extract counteracts palmitate-induced insulin resistance in C2C12 myotubes. 更多 Frontiers in Sustainable Food Systems | |
| 論文著作 (2024) The functional role of N-link glycosylation in a novel cellobiohydrolase II (LsCel6A) from a white-rot fungus Lentinus sp. WR2 更多 International Journal of Biological Macromolecules | |
| 論文著作 (2024) Phytocompounds from essential oil of Mentha aquatica Lime Mint prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRASQ61L keratinocyte and reprogramming macrophage activities 更多 Phytomedicine | |
| 論文著作 (2024) Trifolium pratense as a novel phytogenic supplement, is an anticoccidial agent in chickens.
更多 Poultry Science | |
| 論文著作 (2024) Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis. 更多 Phytomedicine | |
| 論文著作 (2024) Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer 更多 Molecular Oncology | |
| 論文著作 (2024) Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvant 更多 Vaccine | |
| 論文著作 (2023) Phytogalactolipids activate humoral immunity against colorectal cancer 更多 Journal of Experimental & Clinical Cancer Research | |
| 論文著作 (2023) miRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones 更多 Antioxidants & Redox Signaling | |
| 論文著作 (2023) Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549 更多 Applied Biochemistry and Biotechnology | |
| 論文著作 (2023) Phytogenics in ginger, Origanum vulgare, and Syzygium aromaticum and their potential as a feed additive against Clostridium perfringens in broiler production 更多 Animals | |
| 論文著作 (2023) The critical role of galectin-12 in modulating lipid metabolism in sebaceous glands 更多 Journal of Investigative Dermatology | |
| 論文著作 (2022) Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib resistant melanoma via GPX4 inhibition and metabolic reprogramming 更多 Pharmacological Research | |
| 論文著作 (2022) Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study 更多 metabolites | |
| 論文著作 (2022) Cellular and molecular signaling as targets for cancer vaccine therapeutics. 更多 cells | |
| 論文著作 (2021) Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment 更多 International Journal of Molecular Sciences | |
| 論文著作 (2021) Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment 更多 Cancers | |
| 論文著作 (2021) Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice 更多 International Journal of Molecular Sciences | |
| 論文著作 (2021) Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes 更多 BOTANICAL STUDIES | |
| 論文著作 (2020) Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches 更多 Journal of Experimental Botany | |
| 論文著作 (2020) Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa 更多 Plants | |
| 論文著作 (2020) Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease 更多 SCIENTIFIC REPORTS | |
| 論文著作 (2020) Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer 更多 Cancers | |
| 論文著作 (2020) White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice 更多 Food & Nutrition Research | |
| 論文著作 (2019) Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death 更多 Frontiers in Pharmacology | |
| 論文著作 (2019) Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity 更多 Phytomedicine | |
| 論文著作 (2019) Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib. 更多 Molecules | |
| 論文著作 (2019) Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer 更多 Journal of Experimental & Clinical Cancer Research | |
| 論文著作 (2018) Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice 更多 International Journal of Cancer | |
| 論文著作 (2018) Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1 更多 The FEBS Journal | |
| 論文著作 (2017) Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction 更多 Scientific Reports | |
| 論文著作 (2017) Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer 更多 Phytomedicine | |
| 論文著作 (2017) Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death 更多 Oncotarget | |
| 論文著作 (2017) Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions 更多 Frontiers in Pharmacology | |
| 論文著作 (2016) Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics 更多 Pharmacology and Therapeutics | |
| 論文著作 (2016) Novel sesquiterpene lactone analogues as potent anti-breast cancer agents 更多 Molecular Oncology | |
| 論文著作 (2016) A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice 更多 MOLECULAR CANCER THERAPEUTICS | |
| 論文著作 (2016) Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy 更多 Pharmacological Research | |
| 論文著作 (2016) Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells 更多 Phytomedicine | |
| 論文著作 (2015) Structural and functional roles of glycosylation in fungal laccase from Lentinus sp 更多 PLoS ONE | |
| 論文著作 (2015) Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway 更多 Molecular Medicine | |
| 論文著作 (2015) Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice 更多 Food & Function | |
| 論文著作 (2015) New alkaloids from Formosan zoanthid Zoanthus kuroshio 更多 Tetrahedron | |
| 論文著作 (2015) Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches 更多 Evidence-based Complementary and Alternative Medicine | |
| 論文著作 (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells 更多 Journal of Leukocyte Biology | |
| 論文著作 (2013) Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms 更多 Oxidative Medicine and Cellular Longevity | |
| 論文著作 (2013) Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy 更多 Evidence-based Complementary and Alternative Medicine | |
| 論文著作 (2013) Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis 更多 Journal of Nutritional Biochemistry | |
| 論文著作 (2013) A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice 更多 PLoS ONE | |
| 論文著作 (2012) Taxol, camptothecin and beyond for cancer therapy 更多 Advances in Botanical Research | |
| 論文著作 (2012) Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice 更多 Journal of Traditional and Complementary Medicine | |
| 論文著作 (2012) Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer 更多 Breast Cancer Research and Treatment | |
| 論文著作 (2012) Engineering of dual functional hybrid glucanases 更多 Protein Engineering Design & Selection | |
| 論文著作 (2012) Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation 更多 Free Radical Biology & Medicine | |
| 論文著作 (2012) Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1 更多 Protein Engineering Design & Selection | |
| 論文著作 (2012) Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp 更多 Environmental Science and Technology | |
| 論文著作 (2011) Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication 更多 Journal of Traditional and Complementary Medicine | |
| 論文著作 (2011) Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors 更多 Biochemical and Biophysical Research Communication | |
| 論文著作 (2011) Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo 更多 Evidence-based Complementary and Alternative Medicine | |
| 論文著作 (2011) Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection 更多 Journal of Biological Chemistry | |
| 論文著作 (2011) A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression 更多 Phytochemistry | |
| 論文著作 (2011) Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression 更多 Journal of Agricultural and Food Chemistry | |
| 論文著作 (2010) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment 更多 Malaysia patent | |
| 論文著作 (2010) Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways 更多 Phytomedicine | |
| 論文著作 (2010) Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase 更多 PROTEINS: Structure, Function, and Bioinformatics | |
| 論文著作 (2010) Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice 更多 British Journal of Pharmacology | |
| 論文著作 (2010) Current research and development of chemotherapeutic agents for melanoma 更多 Cancers | |
| 論文著作 (2010) Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells 更多 Journal of Proteome Research | |
| 論文著作 (2010) Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants 更多 Journal of Nutritional Biochemistry | |
| 論文著作 (2009) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment 更多 Australia patent issued No. AU 2003244587 | |
| 論文著作 (2009) Truncated glucanase with enhanced activity and method for making the same 更多 (US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies) | |
| 論文著作 (2009) Truncated 1,3-1,4-beta- D-glucanase 更多 US patent issued No. 7,527,958 | |
| 論文著作 (2009) Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase 更多 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | |
| 論文著作 (2009) Cancer and inflammatory disorder treatment 更多 S patent issued No. 7547455 and ROC patents pending | |
| 論文著作 (2008) Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation 更多 (US and ROC patents pending) (One technology licensing/transfer to local biotech company) | |
| 論文著作 (2008) Immunomodulatory phytocompounds and the highly efficient platform to screen the same 更多 US patent pending | |
| 論文著作 (2008) Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase 更多 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | |
| 論文著作 (2008) Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea 更多 (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company) | |
| 論文著作 (2008) Metabolomics for phytomedicine research and drug development 更多 CURRENT OPINION IN CHEMICAL BIOLOGY | |
| 論文著作 (2008) Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators 更多 PHYTOCHEMISTRY | |
| 論文著作 (2008) Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells 更多 BMC Genomics | |
| 論文著作 (2008) Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production 更多 Journal of Agricultural and Food Chemistry | |
| 論文著作 (2008) A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis 更多 Cancer Research | |
| 論文著作 (2008) Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues 更多 Journal of Biomedical Science | |
| 論文著作 (2008) Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition 更多 Journal of Computer-Aided Molecular Design | |
| 論文著作 (2007) Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus 更多 Journal of Medicinal Chemistry | |
| 論文著作 (2007) Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus 更多 Journal of Medicinal Chemistry | |
| 論文著作 (2007) Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression 更多 Journal of Ethnopharmacology | |
| 論文著作 (2007) Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide 更多 Phytomedicine | |
| 論文著作 (2007) Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator 更多 Journal of Ethnopharmacology | |
| 論文著作 (2007) A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma 更多 Cancer Research | |
| 論文著作 (2007) A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7 更多 Planta Medica | |
| 論文著作 (2006) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies 更多 (US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company) | |
| 論文著作 (2006) Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study 更多 Genomics | |
| 論文著作 (2005) The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice 更多 Journal of Biomedical Science | |
| 論文著作 (2005) Phenolic antioxidants from the heatwood of Acacia confusa 更多 Journal of Agricultural and Food Chemistry | |
| 論文著作 (2005) Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin 更多 British Journal of Pharmacology | |
| 論文著作 (2005) Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose 更多 J Mol Biol | |
| 論文著作 (2005) Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity 更多 Holzforschung | |
| 論文著作 (2005) A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance 更多 Biochemistry | |
| 論文著作 (2005) A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance 更多 Biochemistry | |
| 論文著作 (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo 更多 Journal of Biological Chemistry | |
| 論文著作 (2004) Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice 更多 Planta Medica | |
| 論文著作 (2004) Polyacetylenes function as anti-angiogenic agents 更多 Pharmaceutical Research | |
| 論文著作 (2004) Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa 更多 Journal of Ethnopharmacology | |
| 論文著作 (2004) Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells 更多 Journal of Biomedical Science | |
| 論文著作 (2004) Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus 更多 Journal of Biomedical Science | |
| 論文著作 (2004) Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus 更多 J. Biomed. Sci. | |
| 論文著作 (2004) Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood 更多 JOURNAL OF WOOD SCIENCE | |
| 論文著作 (2003) Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing 更多 J. Genet. Mol. Biol. | |
| 論文著作 (2003) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo 更多 Journal of Biological Chemistry | |
| 論文著作 (2003) Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes 更多 JOURNAL OF MOLECULAR BIOLOGY | |
| 論文著作 (2003) Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica 更多 Journal of Agricultural and Food Chemistry | |
| 論文著作 (2002) Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata 更多 Journal of Agricultural and Food Chemistry | |
| 論文著作 (2002) Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme 更多 Biochemistry | |
| 論文著作 (2001) Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability 更多 Journal of Biological Chemistry | |
| 論文著作 (2001) Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes 更多 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | |
| 論文著作 (2001) Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata 更多 Holzforschung |
