Published Papers
| Published Papers (2026) Integrated proteomics and metabolomics reveal phytosesquiterpene lactones DET and DETD-35 inhibit triple-negative breast cancer cell activity by depleting ATP synthesis and reprogramming primary metabolism more Scientific Reports | |
| Published Papers (2026) Traditional, complementary and integrative medicine: A scoping review of international standards and good practice guidelines more Frontiers in Pharmacology | |
| Published Papers (2025) Stimulation of glucose uptake by edible Pholiota nameko (T.Itô) S.Ito & S.Imai extract counteracts palmitate-induced insulin resistance in C2C12 myotubes. more Frontiers in Sustainable Food Systems | |
| Published Papers (2024) The functional role of N-link glycosylation in a novel cellobiohydrolase II (LsCel6A) from a white-rot fungus Lentinus sp. WR2 more International Journal of Biological Macromolecules | |
| Published Papers (2024) Phytocompounds from essential oil of Mentha aquatica Lime Mint prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRASQ61L keratinocyte and reprogramming macrophage activities more Phytomedicine | |
| Published Papers (2024) Trifolium pratense as a novel phytogenic supplement, is an anticoccidial agent in chickens.
more Poultry Science | |
| Published Papers (2024) Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis. more Phytomedicine | |
| Published Papers (2024) Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer more Molecular Oncology | |
| Published Papers (2024) Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvant more Vaccine | |
| Published Papers (2023) Phytogalactolipids activate humoral immunity against colorectal cancer more Journal of Experimental & Clinical Cancer Research | |
| Published Papers (2023) miRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones more Antioxidants & Redox Signaling | |
| Published Papers (2023) Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549 more Applied Biochemistry and Biotechnology | |
| Published Papers (2023) Phytogenics in ginger, Origanum vulgare, and Syzygium aromaticum and their potential as a feed additive against Clostridium perfringens in broiler production more Animals | |
| Published Papers (2023) The critical role of galectin-12 in modulating lipid metabolism in sebaceous glands more Journal of Investigative Dermatology | |
| Published Papers (2022) Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib resistant melanoma via GPX4 inhibition and metabolic reprogramming more Pharmacological Research | |
| Published Papers (2022) Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study more metabolites | |
| Published Papers (2022) Cellular and molecular signaling as targets for cancer vaccine therapeutics. more cells | |
| Published Papers (2021) Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment more International Journal of Molecular Sciences | |
| Published Papers (2021) Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment more Cancers | |
| Published Papers (2021) Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice more International Journal of Molecular Sciences | |
| Published Papers (2021) Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes more BOTANICAL STUDIES | |
| Published Papers (2020) Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches more Journal of Experimental Botany | |
| Published Papers (2020) Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa more Plants | |
| Published Papers (2020) Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease more SCIENTIFIC REPORTS | |
| Published Papers (2020) Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer more Cancers | |
| Published Papers (2020) White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice more Food & Nutrition Research | |
| Published Papers (2019) Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death more Frontiers in Pharmacology | |
| Published Papers (2019) Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity more Phytomedicine | |
| Published Papers (2019) Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib. more Molecules | |
| Published Papers (2019) Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer more Journal of Experimental & Clinical Cancer Research | |
| Published Papers (2018) Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice more International Journal of Cancer | |
| Published Papers (2018) Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1 more The FEBS Journal | |
| Published Papers (2017) Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction more Scientific Reports | |
| Published Papers (2017) Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer more Phytomedicine | |
| Published Papers (2017) Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death more Oncotarget | |
| Published Papers (2017) Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions more Frontiers in Pharmacology | |
| Published Papers (2016) Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics more Pharmacology and Therapeutics | |
| Published Papers (2016) Novel sesquiterpene lactone analogues as potent anti-breast cancer agents more Molecular Oncology | |
| Published Papers (2016) A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice more MOLECULAR CANCER THERAPEUTICS | |
| Published Papers (2016) Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy more Pharmacological Research | |
| Published Papers (2016) Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells more Phytomedicine | |
| Published Papers (2015) Structural and functional roles of glycosylation in fungal laccase from Lentinus sp more PLoS ONE | |
| Published Papers (2015) Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway more Molecular Medicine | |
| Published Papers (2015) Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice more Food & Function | |
| Published Papers (2015) New alkaloids from Formosan zoanthid Zoanthus kuroshio more Tetrahedron | |
| Published Papers (2015) Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells more Journal of Leukocyte Biology | |
| Published Papers (2013) Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms more Oxidative Medicine and Cellular Longevity | |
| Published Papers (2013) Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2013) Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis more Journal of Nutritional Biochemistry | |
| Published Papers (2013) A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice more PLoS ONE | |
| Published Papers (2012) Taxol, camptothecin and beyond for cancer therapy more Advances in Botanical Research | |
| Published Papers (2012) Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice more Journal of Traditional and Complementary Medicine | |
| Published Papers (2012) Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer more Breast Cancer Research and Treatment | |
| Published Papers (2012) Engineering of dual functional hybrid glucanases more Protein Engineering Design & Selection | |
| Published Papers (2012) Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation more Free Radical Biology & Medicine | |
| Published Papers (2012) Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1 more Protein Engineering Design & Selection | |
| Published Papers (2012) Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp more Environmental Science and Technology | |
| Published Papers (2011) Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication more Journal of Traditional and Complementary Medicine | |
| Published Papers (2011) Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors more Biochemical and Biophysical Research Communication | |
| Published Papers (2011) Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2011) Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection more Journal of Biological Chemistry | |
| Published Papers (2011) A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression more Phytochemistry | |
| Published Papers (2011) Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression more Journal of Agricultural and Food Chemistry | |
| Published Papers (2010) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment more Malaysia patent | |
| Published Papers (2010) Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways more Phytomedicine | |
| Published Papers (2010) Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase more PROTEINS: Structure, Function, and Bioinformatics | |
| Published Papers (2010) Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice more British Journal of Pharmacology | |
| Published Papers (2010) Current research and development of chemotherapeutic agents for melanoma more Cancers | |
| Published Papers (2010) Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells more Journal of Proteome Research | |
| Published Papers (2010) Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants more Journal of Nutritional Biochemistry | |
| Published Papers (2009) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment more Australia patent issued No. AU 2003244587 | |
| Published Papers (2009) Truncated glucanase with enhanced activity and method for making the same more (US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies) | |
| Published Papers (2009) Truncated 1,3-1,4-beta- D-glucanase more US patent issued No. 7,527,958 | |
| Published Papers (2009) Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase more BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | |
| Published Papers (2009) Cancer and inflammatory disorder treatment more S patent issued No. 7547455 and ROC patents pending | |
| Published Papers (2008) Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation more (US and ROC patents pending) (One technology licensing/transfer to local biotech company) | |
| Published Papers (2008) Immunomodulatory phytocompounds and the highly efficient platform to screen the same more US patent pending | |
| Published Papers (2008) Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase more ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | |
| Published Papers (2008) Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea more (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company) | |
| Published Papers (2008) Metabolomics for phytomedicine research and drug development more CURRENT OPINION IN CHEMICAL BIOLOGY | |
| Published Papers (2008) Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators more PHYTOCHEMISTRY | |
| Published Papers (2008) Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells more BMC Genomics | |
| Published Papers (2008) Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production more Journal of Agricultural and Food Chemistry | |
| Published Papers (2008) A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis more Cancer Research | |
| Published Papers (2008) Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues more Journal of Biomedical Science | |
| Published Papers (2008) Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition more Journal of Computer-Aided Molecular Design | |
| Published Papers (2007) Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus more Journal of Medicinal Chemistry | |
| Published Papers (2007) Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus more Journal of Medicinal Chemistry | |
| Published Papers (2007) Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression more Journal of Ethnopharmacology | |
| Published Papers (2007) Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide more Phytomedicine | |
| Published Papers (2007) Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator more Journal of Ethnopharmacology | |
| Published Papers (2007) A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma more Cancer Research | |
| Published Papers (2007) A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7 more Planta Medica | |
| Published Papers (2006) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies more (US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company) | |
| Published Papers (2006) Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study more Genomics | |
| Published Papers (2005) The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice more Journal of Biomedical Science | |
| Published Papers (2005) Phenolic antioxidants from the heatwood of Acacia confusa more Journal of Agricultural and Food Chemistry | |
| Published Papers (2005) Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin more British Journal of Pharmacology | |
| Published Papers (2005) Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose more J Mol Biol | |
| Published Papers (2005) Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity more Holzforschung | |
| Published Papers (2005) A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance more Biochemistry | |
| Published Papers (2005) A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance more Biochemistry | |
| Published Papers (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo more Journal of Biological Chemistry | |
| Published Papers (2004) Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice more Planta Medica | |
| Published Papers (2004) Polyacetylenes function as anti-angiogenic agents more Pharmaceutical Research | |
| Published Papers (2004) Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa more Journal of Ethnopharmacology | |
| Published Papers (2004) Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells more Journal of Biomedical Science | |
| Published Papers (2004) Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus more Journal of Biomedical Science | |
| Published Papers (2004) Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus more J. Biomed. Sci. | |
| Published Papers (2004) Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood more JOURNAL OF WOOD SCIENCE | |
| Published Papers (2003) Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing more J. Genet. Mol. Biol. | |
| Published Papers (2003) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo more Journal of Biological Chemistry | |
| Published Papers (2003) Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes more JOURNAL OF MOLECULAR BIOLOGY | |
| Published Papers (2003) Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica more Journal of Agricultural and Food Chemistry | |
| Published Papers (2002) Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata more Journal of Agricultural and Food Chemistry | |
| Published Papers (2002) Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme more Biochemistry | |
| Published Papers (2001) Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability more Journal of Biological Chemistry | |
| Published Papers (2001) Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes more ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | |
| Published Papers (2001) Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata more Holzforschung |
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— Lie-Fen Shyur
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| Research (9) |
| Issued Patents (15) |
| Published Papers (120) |
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