Molecular basis of shikonin-induced immunogenic cell death: insights for developing cancer therapeutics Receptors & Clinical Investigation
論文著作 (2016)
Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis Nature Communications
論文著作 (2016)
Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1 Oncotarget
論文著作 (2016)
Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis Scientific Reports
論文著作 (2015)
Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasi PLoS One
論文著作 (2015)
Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells Journal of Leukocyte Biology
論文著作 (2015)
Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components Molecular Cancer
論文著作 (2015)
Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine PLoS One
論文著作 (2014)
Tumor-associated antigen/IL-21-transduced dendritic cell vaccines enhance immunity and inhibit immunosuppressive cells in metastatic melanoma Gene Therapy
論文著作 (2013)
The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing Evidence-based Complementary and Alternative Medicine
論文著作 (2013)
Integration of different “-omics” technologies identifies inhibition of the IGF1R-Akt-mTOR signaling cascade involved in the cytotoxic effect of shikonin against leukemia cells Evidence-based Complementary and Alternative Medicine
論文著作 (2013)
Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-induced Colitis in Mice PLoS One
論文著作 (2013)
Therapeutic Applications of Herbal Medicines for Cancer Patients Evidence-based Complementary and Alternative Medicine
論文著作 (2013)
Specific Dioscorea phytoextracts enhance potency of TCL-loaded DC-based cancer vaccine Evidence-based Complementary and Alternative Medicine
論文著作 (2013)
Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008–2012 Marine Drugs
論文著作 (2012)
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES J. Biomed. Sci.
論文著作 (2012)
Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin vai post-translational mechanisms Journal of Nutritional Biochemistry
論文著作 (2012)
Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms PLoS One
論文著作 (2012)
Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine Cancer Immunology Immunotherapy
論文著作 (2011)
Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin Journal of Biomedical Science
論文著作 (2011)
Dioscorea phytocompounds synergistically enhance interleukin-2-mediated murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo Evidence-based Complementary and Alternative Medicine
論文著作 (2011)
Specific microtubule-depolymerizing agents augment effcacy of dendritic cell-based cancer vaccine Journal of Biomedical Science
論文著作 (2011)
Interleukin-4 enhances trafficking and functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage Experimental Cell Research
論文著作 (2010)
Cytotoxic C-35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica Organic Letters
論文著作 (2010)
Anti-Inflammatory Plant Natural Products for Cancer Therapy Planta Medica
論文著作 (2010)
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling BMC Genomics
論文著作 (2010)
Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses BMC Genomics
論文著作 (2010)
Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants Journal of Nutritional Biochemistry
論文著作 (2009)
Protective immunity against porcine circovirus 2 in mice induced by a gene-based combination vaccination The Journal of Gene Medicine
論文著作 (2009)
Functional genomics of immuno-modulatory activities of medicinal plant extracts/phytocompounds in human dendritic cells/monocytes Planta Medica
論文著作 (2009)
Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma Gene Therapy
論文著作 (2008)
Metabolomics for phytomedicine research and drug development Current Opinion in Chemical Biology
論文著作 (2008)
Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells BMC Genomics
論文著作 (2008)
Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues Journal of Biomedical Science
論文著作 (2007)
Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var formosana Tetrahedron Letters
論文著作 (2007)
Inhibition of tumor necrosis factor-alpha through selective blockade of pre-mRNA splicing by shikonin Molecular Pharmacology
論文著作 (2007)
A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma Cancer Research
論文著作 (2007)
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus Journal of Medicinal Chemistry
論文著作 (2006)
DNA vaccination against foot-and-mouth disease via electroporation: Study of molecular approaches for enhancing VP1 antigenicity. The Journal of Gene Medicine
論文著作 (2006)
Caffeic acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse Carcinogenesis
論文著作 (2006)
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study Genomics
論文著作 (2005)
A glycine-rich protein gene family predominantly expressed in tomato roots, but not in leaves and ripe fruit Plant Science
論文著作 (2005)
Comparative studies of the capsid precursor polypeptide P1 and the capsid protein VP1 cDNA vectors for DNA vaccination against foot-and-mouth diseases virus The Journal of Gene Medicine
論文著作 (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance Biochemistry
論文著作 (2005)
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin British Journal of Pharmacology
論文著作 (2004)
Molecular strategies for improving cytokine transgene expression in normal and malignant tissues Gene Therapy
論文著作 (2004)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
論文著作 (2004)
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells Journal of Biomedical Science
論文著作 (2004)
Expression of bioactive human interferon-gamma protein in transgenic rice suspension cells Transgenic Research
論文著作 (2004)
Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus Journal of Biomedical Science
論文著作 (2004)
Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases Transgenic Research
論文著作 (2003)
Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing Journal of Genetics and Molecular Biology
論文著作 (2003)
In silico identification and phylogenetic analysis of putative plant arylalkylamine N-acetyl-transferase J Genet Mol Biol
論文著作 (2003)
Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica Journal of Agricultural and Food Chemistry
論文著作 (2003)
The sweet pepper ferredoxin-like protein (pflp) conferred resistance against soft rot disease in Oncidium orchid Transgenic Research
論文著作 (2003)
Agrobacterium tumefaciens-mediated transformation of an Oncidium orchid Plant Cell Reports
論文著作 (2003)
Tissue array transgene expression system for the evolution of effect of medicinal herbs on wound-healing Journal of Genetics and Molecular Biology
論文著作 (2003)
In Silico identification and phylogenetic analysis of an unique GNAT-type of acetyltransferases in plants Journal of Genetics and Molecular Biology
論文著作 (2002)
Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata Journal of Agricultural and Food Chemistry
論文著作 (2002)
Direct gene transfer and vaccination via skin transfection using a gene gun Methods in Molecular Medicine
論文著作 (2002)
Profiling and characterization antioxidant activities in Anoectochilus formosanus hayata Journal of Agricultural and Food Chemistry
論文著作 (2002)
Relative promoter strengths in four human prostate cancer cell lines evaluated by particle bombardment-mediated gene transfer The Prostate
論文著作 (2002)
Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme Biochemistry
論文著作 (2002)
Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model Molecular Cancer Therapeutics
論文著作 (2002)
Immunization by particle-mediated transfer of the granulocyte-macrophage colony-stimulating factor gene into autologous tumor cells in melanoma or sarcoma patients: report of a phase I/IB study Human Gene Therapy
論文著作 (2002)
Fas-Fas ligand signaling pathway mediates an interleukin-12-induced rejection of a murine prostate tumor system The Prostate
論文著作 (2001)
Truncated glucanase with enhanced activity and method for making the same US and ROC patent
論文著作 (2001)
Interleukin-12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer Human Gene Therapy
論文著作 (2001)
Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor Clinical Cancer Research
論文著作 (2001)
Antioxidant activity of extracts from Acacia confusa bark and heartwood Journal of Agricultural and Food Chemistry
論文著作 (2000)
The use of particle-mediated gene transfer for the study of promoter activity in somatic tissues Methods in Molecular Biology
論文著作 (2000)
Regulation of cell proliferation, gene expression, production ofcytokines, and cell cycle progression in primary human T lymphocytes b Mol Pharmacol
論文著作 (2000)
Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism Cancer Gene Therapy
論文著作 (2000)
Regulation of cell proliferation, gene expression, production of cytokines, and cell cycle progression in primary human T lymphocytes by piperlactam S isolated from Piper kadsura Molecular Pharmacology
論文著作 (1999)
Preclinical development of human granulocyte-macrophage colony-stimulatingfactor-transfected melanoma cell vaccine using established canine cel Cancer Gene Therapy
論文著作 (1999)
Inhibition of tumor growth in Lewis lung carcinoma in mice by combination of mIL-12 and IL-18 cDNA Am J Respir Crit Care Med
論文著作 (1999)
Gene gun-mediated IL-12 gene therapy induces antitumor effects in theabsence of toxicity: a direct comparison with systemic IL-12 protei J Immunother
論文著作 (1999)
Preclinical development of human granulocyte-macrophage colony-stimulating factor-transfected melanoma cell vaccine using established canine cell lines and normal dogs Cancer Gene Therapy
論文著作 (1999)
Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy Journal of Immunotherapy
論文著作 (1999)
Interleukin-12 cDNA skin transfection potentiates human papillomavirus E6 DNA vaccine-induced antitumor immune response Cancer Gene Therapy
論文著作 (1999)
Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
重要發現與突破 (2015)
建立三維乳腺瘤組織培養系統以探討三種植化藥物在腫瘤微環境中所引起免 疫檢驗機制之調控作用
重要發現與突破 (2013)
於膳食攝取蟛蜞菊萃取物可減弱葡聚醣硫酸鈉於小鼠動物模式所誘導的結腸炎
重要發現與突破 (2012)
酚類植化物阿魏酸可藉由轉譯後機制來抑制UVB在小鼠皮膚誘導之基質金屬蛋白酶
重要發現與突破 (2012)
膳食中之青蔥萃取物可有效地抑制大腸腫瘤生長:小鼠的細胞和分子機制
重要發現與突破 (2011)
細胞介白素-4能增強GM-CSF刺激後的小鼠骨髓樹突狀細胞在後期分化階段的販運和功能性活動
重要發現與突破 (2010)
基因體及蛋白質體研究證實紫錐菊萃取物能促進老鼠樹突狀細胞於體內之遷移能力
重要發現與突破 (2010)
利用比較性功能基因體學來研究具有免疫調節活性之中草藥對訊息路徑的影響
重要發現與突破 (2009)
利用山藥萃取物來刺激骨髓或脾臟細胞增生之效果
重要發現與突破 (2009)
在特定的時間點下轉基因表現人類gp100和細胞趨化素RANTES抑制黑色素瘤之研究
重要發現與突破 (2008)
紫錐菊對人類樹突狀免疫細胞之基因體學及蛋白質體學研究
重要發現與突破 (2004)
利用金線連植物萃取物為癌症預防(治療)之藥物或功能性食品
重要發現與突破 (2002)
利用金線連植物萃取物為癌症預防(治療)之藥物或功能性食品
重要特殊獎項 (2014-10)
台灣生醫暨生農產業選秀大賽 生農組 潛力新秀獎
重要特殊獎項 (2006)
Fellow of the American Association for the Advancement of Science (AAAS)
