農生中心相片 點選關閉


Hsin-Yi Chen, Shu-Jou Chan, Xinxin Liu, An-Chi Wei, Ru-In Jian, Kuan-Wei Huang, Yaw-Dong Lang, Jou-Ho Shih, Chun-Chieh Liao, Chiu-Lin Luan, Yu-Tung Kao, Shang-Yin Chiang, (Pei-Wen Hsiao), Yuh-Shan Jou, Yunching Chen & Ruey-Hwa Chen* (2022) Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression. JOURNAL OF HEMATOLOGY & ONCOLOGY, 15, 85
Hsin-Ying Lin, Chun-Jung Ko, Tzu-Yu Lo, Shang-Ru Wu, Shao-Wei Lan, Chen-An Huang, Yi-Chin Lin, Hsin-Hsien Lin, Hsin-Fang Tu, Cheng-Fan Lee, (Pei-Wen Hsiao), Hsiang-Po Huang, Mei-Jou Chen, Kai-Hsiung Chang & Ming-Shyue Lee* (2022) Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis. ONCOGENE, 41, 2833-2845
Pin-Yu Huang, Yu-Chih Yang, Chun-I Wang, Pei-Wen Hsiao, Hsin-I Chiang*, Ting-Wen Chen* (2021) Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice. International Journal of Molecular Sciences, 22(17), 9626
Yo Ping Lai, Lu Cheng Kuo, Been Ren Lin, Hung Ju Lin, Chih Yu Lin, Yi Ting Chen, Pei Wen Hsiao, Huan Tsung Chang, Patrick Chow In Ko, Hsiao Chin Chen, Hsiang Yu Chang, Jean Lu, Hong Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu Ching Chen* (2021) CD28 engagement inhibits CD73-mediated regulatory activity of CD8+T cells. Communications Biology, 4, 595
Dean Huang, Yu-Chan Chao, Zhengbing Lv, Jia-Tsrong Jan, Yu-Chih Yang, Pei-Wen Hsiao, Chia-Ying Wu, Chiu-Hsun Liao, Tzu-Hsien Wu, Lih-Chiann Wang* (2021) Comparison of Chicken Immune Responses after Inoculation with H5 Avian Influenza Virus-like Particles Produced by Insect Cells or Pupae. JOURNAL OF VETERINARY RESEARCH, 65(2), 139-145
Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen, Hsing-Jien Kung* (2021) Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells. NATURE COMMUNICATIONS, 12, 2398
Biljana Cvetanova, Meng-Yi Li, Chung-Chih Yang, Pei-Wen Hsiao, Yu-Chih Yang, Jia-Hua Feng, Ya-Ching Shen, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur* (2021) Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAF V600E Mutant Melanoma Lung Metastasis in Mice. International Journal of Molecular Sciences, 22(6), 3226
Chih-Wei Fu, Han-En Tsai, Wei-Sheng Chen, Tzu-Ting Chang, Chia-Ling Chen, Pei-Wen Hsiao, Wen-Shan Li* (2021) Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis. Journal of Medicinal Chemistry, 64(1), 527-542
Chun-Jung Ko, Ting-Wei Hsu, Shang-Ru Wu, Shao-Wei Lan, Ting-Feng Hsiao, Hsin-Ying Lin, Hsin-Hsien Lin, Hsin-Fang Tu, Cheng-Fan Lee, Cheng-Chung Huang, Mei-Ju May Chen, Pei-Wen Hsiao, Hsiang-Po Huang, Ming-Shyue Lee* (2020) Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. ONCOGENE, 39, 5950-5963
Maria Karmella Apaya , Pei-Wen Hsiao, Yu-Chih Yang Lie-Fen Shyur* (2020) Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer. Cancers, 12(1), 199
Liao GY, Lee MT, Fan JJ, Hsiao PW, Lee CS, Su SY, Hwang JJ*, Ke FC* (2019) Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response. BIOLOGY OPEN, 8(5), bio038257
Wu CY, Yu SL, Chen YT, Chen YH, Hsiao PW, Chow YH*, Chen JR* (2019) The mature EV71 virion induced a broadly cross-neutralizing VP1 antibody against subtypes of the EV71 virus. PLOS ONE, 14(1), e0210553
Sheng-Yen Lin, Sung-Yuan Hsieh, Yi-Ting Fan, Wen-Chi Wei, Pei-Wen Hsiao, Dai-Hua Tsai, Tzong-Shoon Wu, and Ning-Sun Yang* (2018) Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance. Autophagy, 14(5), 778-795
Tien-Jen Lin, Shu-Yi Yin, Pei-Wen Hsiao, Ning-Sun Yang and I-Jen Wang* (2018) Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis. Scientific Reports, 8, 14927
Sheue-Fen Tzeng, Chin-Hsien Tsai, Tai-Kuang Chao, Yu-Ching Chou, Yu-Chih Yang, Mong-Hsun Tsai, Tai-Lung Cha, and Pei-Wen Hsiao* (2018) O-Glycosylation–mediated signaling circuit drives metastatic castration-resistant prostate cancer. FASEB JOURNAL, 32, 6869-6882
Cheng-Ying Shen, Ya-Chu Chang, Li-Han Chen, Wen-Chun Lin, Yung-Hua Lee, Shu-Tsen Yeh, Hsin-Kuang Chen, Wentao Fang, Chung-Ping Hsu, Jang-Ming Lee, Tzu-Pin Lu, Pei-Wen Hsiao, Liang-Chuan Lai, Mong-Hsun Tsai* and Eric Y. Chuang* (2018) The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells. Oncogenesis, 7(12), 95
Ji-Rong Yang, Chieh-Yu Cheng, Chih-Yuan Chen, Chao-Hua Lin, Chuan-Yi Kuo, Hsiang-Yi Huang, Fu-Ting Wu, Yu-Chih Yang, Chia-Ying Wu, Ming-Tsan Liu*, and Pei-Wen Hsiao* (2017) A virus-like particle vaccination strategy expands its tolerance to H3N2 antigenic drift by enhancing neutralizing antibodies against hemagglutinin stalk. Antiviral Research, 140, 62-75
Chin-Hsien Tsai, Sheue-Fen Tzeng, Shih-Chuan Hsieh, Chia-Jui Tsai, Yu-Chih Yang, Mong-Hsun Tsai, and Pei-Wen Hsiao* (2017) A Standardized Wedelia chinensis extract overcomes the Feedback activation of HER2/3 signaling upon androgen-ablation in prostate cancer. Frontiers in Pharmacology, 8, 721
Chin-Hsien Tsai, Sheue-Fen Tzeng, Shih-Chuan Hsieh, Yu-Chih Yang, Yi-Wen Hsiao, Mong-Hsun Tsai, and Pei-Wen Hsiao*. (2017) A Standardized Wedelia chinensis extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer. SCIENTIFIC REPORTS, 7(1), 15624
Li TW, Cheng SF, Tseng YT, Yang YC, Liu WC, Wang SC, Chou MJ, Lin YJ, Wang Y, Hsiao PW, Wu SC, Chang DK* (2016) Development of single-chain variable fragments (scFv) against influenza virus targeting hemagglutinin subunit 2 (HA2). Archives of Virology, 161(1), 19-31
Yang JR, Chen CY, Kuo CY, Cheng CY, Lee MS, Cheng MC, Yang YC, Wu CY, Wu HS, Liu MT*, Hsiao PW* (2016) A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses. Antiviral Research, 126, 8-17
Shu-Yi Yin, Feng-Yin Jian, Yung-Hsiang Chen, Shih-Chang Chien, Mao-Chih Hsieh, Pei-Wen Hsiao, Wen-Hwa Lee, Yueh-Hsiung Kuo* and Ning-Sun Yang* (2016) Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis. Nature Communications, 7, 11311
Shu-Yi Yin, Thomas Efferth, Feng-Yin Jian, Yung-Hsiang Chen, Chia-I Liu3, Andrew H.J. Wang, Yet-Ran Chen, Pei-Wen Hsiao, Ning-Sun Yang* (2016) Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1. Oncotarget, 7(28), 43629-43653
Chin-Hsien Tsai, Sheue-Fen Tzeng, Tai-Kuang Chao, Chia-Yun Tsai, Yu-Chih Yang, Ming-Ting Lee, Jiuan-Jiuan Hwang, Yu-Ching Chou, Mong-Hsun Tsai, Tai-Lung Cha and Pei-Wen Hsiao* (2016) Metastatic progression of prostate cancer is mediated by autonomous binding of galectin-4-O-glycan to cancer cells. Cancer Research, 76 (19), 5756-5767
Tsai CH, Tzeng SF, Hsieh SC, Lin CY, Tsai CJ, Yang YC, Hsiao JH, Tsai MH, Lee MT, and Hsiao PW* (2015) Development of a standardized and effect-optimized herbal extract of Wedelia chinensis for prostate cancer. Phytomedicine, 22(3), 406-414
Ko CJ, Huang CC, Lin HY, Juan CP, Lan SW, Shyu HY, Wu SR, Hsiao PW, Huang HP, Shun CT, Lee MS*. (2015) Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis. Cancer Research, 75(14), 2949-2960
Wu CY, Lin YW, Kuo CH, Liu WH, Tai HF, Pan CH, Chen YT, Hsiao PW, Chan CH, Chang CC, Liu CC, Chow YH, Chen JR*. (2015) Inactivated enterovirus 71 vaccine produced by 200-l scale serum-free microcarrier bioreactor system provides cross-protective efficacy in human SCARB2 transgenic mouse. PLoS One, 10(8), e0136420
Lin TJ, Lin HT, Chang WT, Mitapalli S P, Hsiao PW, Yin SY, Yang NS*. (2015) Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components. Molecular Cancer, 14, 174
Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, Lin VC, Yu DS, Cha TL*. (2015) Novel Cancer Therapeutics with Allosteric modulation of the mitochondrial c-Raf-DAPK complex by Raf inhibitor combination therapy . Cancer Research, 75(17), 3568-3582
Lin TJ, Liang WM, Hsiao PW, M S P, Wei WC, Lin HT, Yin SY, Yang NS*. (2015) Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine. PLoS One, 10(10), e0138335
Fu CW, Hsieh YJ, Chang TT, Chen CL, Yang CY, Liao A, Hsiao PW, Li WS*. (2015) Anticancer efficacy of unique pyridine-based tetraindoles. European journal of medicinal chemistry, 104, 165-176
Lin YJ, Wu CY, Li T, Hsiao PW and Chang DK* (2014) Rapid and sensitive early diagnosis of influenza virus subtype via surface enhanced Raman scattering. J Biosens Bioelectron, 5, 150
Wang CH, Chen CL, More SV, Hsiao PW, Hung WC, Li WS. (2014) The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family. PLoS ONE, 9(6), e101088
Wu CY, Chang CY, Ma, HH, Wang CW, Chen YT, Hsiao PW, Chang CC, Chan CH, Liu CC, Chen JR*. (2014) Squalene-adjuvanted H7N9 virus vaccine induces robust humoral immune response against H7N9 and H7N7 viruses. Vaccine, 32(35), 4485-4494
Tsai CH, Teng CH, Cheng TS, Tu YT, Wu SR, Shyu HY, Ko CJ , Lan SW, Huang HP, Johnson MD, Lin CY, Hsiao PW *, Lee MS* (2014) HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase. ONCOGENE, 33(38), 4643-4652
Tang SH, Huang HS, Wu HU, Tsai YT, Chuang MJ, Yu CP, Huang SM, Sun GH, Chang SY, Hsiao PW, Yu DS, Cha, TL* (2014) Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in vitro and in vivo. Oncotarget, 5(21), 10342-10355
Huang YT, Wen CC, Chen YH, Huang WC, Huang LT, Lin WC, Arulselvan P, Liao JW, Lin SH, Hsiao PW, Kuo SC, Yang NS (2013) Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice. PLoS One, 8(5), e64152
Cheng TS, Chen WC, Lin YY, Tsai CH, Liao CI, Shyu HY, Ko CJ, Tzeng SF, Huang CY, Yang PC, Hsiao PW, and Lee MS* (2013) Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth and metastasis. Cancer Prevention Research, 6(5), 495-505
Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD and Juan LJ* (2013) Histone demethylase retinoblastoma binding protein-2 promotes lung tumorigenesis and cancer metastasis. Cancer Research, 73(15), 4711-4721
Wu CY, Yeh YC, Chan JT, Yang YC, Yang JR, Liu MT, Wu HS, Hsiao PW* (2012) A VLP Vaccine Induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza a virus. PLoS One, 7, e42363
Hsu CH, Peng KL, Kang ML, Chen YR, ChuCS, Yang YC, Tsai CH, Jeng YM, Chen YT, Lin FM, Huang HD, Lu YY, Teng Yching, Lin ST, Shen L, Lin RK, Lee SB, Hsu H M, Yu JC*, Hsiao PW* and Juan LJ * (2012) TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell Reports, 2(3), 568-579
Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, and Chen RH*. (2011) A Cullin3-KLHL20 ubiqutin ligase-dependent pathway targets PML to amplify HIF-1 signaling and tumor hypoxia responses. CANCER CELL, 20, 214-228
Chia-Ying Wu, Yi-Chun Yeh, Yu-Chih Yang, Ching Chou, Ming-Tsan Liu, Ho-Sheng Wu, Jia-Tsrong Chan, Pei-Wen Hsiao* (2010) Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus. PLoS One, e9784
Tai-Lung Cha*, Mei-Jen Chuang, Sheng-Tang Wu, Guang-Huan Sun, Sun-Yran Chang, Dah-ShyongYu, Shih-Ming Huang, Steven Kuan-Hua Huan, Tse-Chou Cheng, Tzu-Ting Chen, Pao-Luo Fan, Pei-Wen Hsiao (2009) Dual Degradation of Aurora A and B Kinases by the Histone Deacetylase Inhibitor LBH589 Induces G2-M Arrest and Apoptosis of Renal Cancer Cells. CLINICAL CANCER RESEARCH, 15(3), 840-850
Chin-Hsien Tsai, Feng-Min Lin, Yu-Chih Yang, Ming-Ting Lee, Tai-Lung Cha, Guan-James Wu, Shih-Chuan Hsieh, Pei-Wen Hsiao* (2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice. CLINICAL CANCER RESEARCH, 15, 5435-5444
Feng-Min Lin, Chin-Hsien Tsai, Yu-Chih Yang, Wei-Chun Tu, Li-Ru Chen, Yun-Sa Liang,Sheng-Yang Wang, Lie-Fen Shyur, Shih-Chang Chien, Tai-Lung Cha, Pei-Wen Hsiao* (2008) A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through anti-proliferation and pro-apoptosis. Cancer Research, 68(16), 6634-6642
Yun-Ju Chen, Ming-Ting Lee, Hsiao-Chun Yao, Pei-Wen Hsiao, Ferng-Chun Ke*, Jiuan-Jiuan Hwang* (2008) Crucial Role of Estrogen Receptor-α Interaction with Transcription Coregulators in Follicle-StimulatingHormone and Transforming Growth Factor β1 Up-Regulation of Steroidogenesis in Rat Ovarian Granulosa Cells. ENDOCRINOLOGY, 149(8), 4658-4668
Yun-Ju Chen, Pei-Wen Hsiao, Ming-Ting Lee, J Ian Mason, Ferng-Chun Ke*, Jiuan-Jiuan Hwang* (2007) Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFß1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells . JOURNAL OF ENDOCRINOLOGY, 192, 405-419
Sui-Wen Lin, Ferng-Chun Ke, Pei-Wen Hsiao, Ping-Ping Lee, Ming-Ting Lee*, Jiuan-Jiuan Hwang* (2007) Critical involvement of ILK in TGFβ1-stimulated invasion/migration of human ovarian cancer cells is associated with urokinase plasminogen activator system. Experimental Cell Research, 313, 602-613
Chih-Chun Wen, Yueh-Hsiung Kuo, Jia-Tsrong Jan, Po-Huang Liang, Sheng-Yang Wang, Hong-Gi Liu, Ching-Kuo Lee, Shang-Tzen Chang, Chih-Jung Kuo, Shoei-Sheng Lee, Chia-Chung Hou, Pei-Wen Hsiao, Shih-Chang Chien, Lie-Fen Shyur,* Ning-Sun Yang* (2007) Specific plant terpenoids and Ligands Possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of Medicinal Chemistry, 50, 4087-4095
Wei-Chun Tu, Sheng-Yang Wang, Shih-Chang Chien, Feng-Min Lin, Li-Ru Chen, Chih-Yang Chiu, Pei-Wen Hsiao* (2007) Diterpenes from Cryptomeria japonica Inhibit Androgen Receptor Transcriptional Activity in Prostate Cancer Cells. Planta Medica, 73, 1407-1409
Feng-Min Lin, Li-Ru Chen, En-Hau Lin, Ferng-Chun Ke, Hsin-Yi Chen, Meng-Jen Tsai, Pei-Wen Hsiao* (2007) Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells. CARCINOGENESIS, 28(12), 2521-2529
Ho-sheng Wu, Yueh-chun Hsieh, Ih-jen Su, Ting-hsiang Lin, Shu-chun Chiu, Yu-Fen Hsu, Jih-Hui Lin, Mei-Ching Wang, Jeou-Yuan Chen, Pei-Wen Hsiao, Geen-Dong Chang, Andrew H J Wang, Hsien-Wei Ting, Chih-Ming Chou*, Chang-Jen Huang* (2004) Early detection of antibodies against various structural proteins of the SARS-associated coronavirus in SARS patients. Journal of Biomedical Science, 11, 117-126
Chang-Chi Lin, Chih-Ming Chou, Ya-Li Hsu, Jih-Ching Lien, Yu-Ming Wang, Shui-Tsung Chen, Shu-Chuan Tsai, Pei-Wen Hsiao, Chang-Jen Huang* (2004) Characterization of two mosquito STATs, AaSTAT and CtSTAT: Differential regulation of tyrosine hosphorylation and DNA binding activity by LPS treatment and by Japanese encephalitis virus infection. Journal of Biological Chemistry, 279, 3308-3317
Pei-Wen Hsiao, Christy J. Fryer, Kevin W. Trotter, Weidong Wang, Trevor K Archer* (2003) BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. MOLECULAR AND CELLULAR BIOLOGY, 23, 6210-6220
P. W. Hsiao, B. J. Deroo and T. K. Archer (2002) Chromatin remodeling and tissue-selective responses of nuclear hormone receptors. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 80, 343-351
P. W. Hsiao, D. L. Lin, T. Thin and C. S. Chang (2000) Differential regulation of testosterone vs. 5 α-dihydrotestosterone by selective androgen response elements. MOLECULAR AND CELLULAR BIOCHEMISTRY, 206, 169-175
P. W. Hsiao, D. L. Lin, R. Nakao and C. Chang (1999) The linkage of Kennedy's disease to Ran/ARA24, identified as the first androgen receptor poly-glutamine region associated coactivator. Journal of Biological Chemistry, 274, 20229-20234
P. W. Hsiao and C. Chang (1999) Isolation and characterization of ARA160 as the first androgen receptor N-terminal associated coactivator in human prostate cells. Journal of Biological Chemistry, 274, 22373-22379
葉國楨 楊玉良 葉信宏 徐麗芬 邱子珍 常怡雍 楊文欽 蕭培文 詹明才 方素瓊 陳逸然 陳荷明 劉明容 孫德芬 何承訓 林耀正 山田昌史 林于鈴 林哲揚 吳岱娜 陳繪名 陳韻竹 林崇熙 辜瑞雪 梁佑全 董啟功 匡麟芸 鄭思齊