Molecular basis of shikonin-induced immunogenic cell death: insights for developing cancer therapeutics Receptors & Clinical Investigation
Published Papers (2016)
Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis Nature Communications
Published Papers (2016)
Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1 Oncotarget
Published Papers (2016)
Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis Scientific Reports
Published Papers (2015)
Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasi PLoS One
Published Papers (2015)
Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells Journal of Leukocyte Biology
Published Papers (2015)
Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components Molecular Cancer
Published Papers (2015)
Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine PLoS One
Published Papers (2014)
Tumor-associated antigen/IL-21-transduced dendritic cell vaccines enhance immunity and inhibit immunosuppressive cells in metastatic melanoma Gene Therapy
Published Papers (2013)
The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Integration of different “-omics” technologies identifies inhibition of the IGF1R-Akt-mTOR signaling cascade involved in the cytotoxic effect of shikonin against leukemia cells Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-induced Colitis in Mice PLoS One
Published Papers (2013)
Therapeutic Applications of Herbal Medicines for Cancer Patients Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Specific Dioscorea phytoextracts enhance potency of TCL-loaded DC-based cancer vaccine Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008–2012 Marine Drugs
Published Papers (2012)
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES J. Biomed. Sci.
Published Papers (2012)
Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin vai post-translational mechanisms Journal of Nutritional Biochemistry
Published Papers (2012)
Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms PLoS One
Published Papers (2012)
Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine Cancer Immunology Immunotherapy
Published Papers (2011)
Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin Journal of Biomedical Science
Published Papers (2011)
Dioscorea phytocompounds synergistically enhance interleukin-2-mediated murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo Evidence-based Complementary and Alternative Medicine
Published Papers (2011)
Specific microtubule-depolymerizing agents augment effcacy of dendritic cell-based cancer vaccine Journal of Biomedical Science
Published Papers (2011)
Interleukin-4 enhances trafficking and functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage Experimental Cell Research
Published Papers (2010)
Cytotoxic C-35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica Organic Letters
Published Papers (2010)
Anti-Inflammatory Plant Natural Products for Cancer Therapy Planta Medica
Published Papers (2010)
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling BMC Genomics
Published Papers (2010)
Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses BMC Genomics
Published Papers (2010)
Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants Journal of Nutritional Biochemistry
Published Papers (2009)
Protective immunity against porcine circovirus 2 in mice induced by a gene-based combination vaccination The Journal of Gene Medicine
Published Papers (2009)
Functional genomics of immuno-modulatory activities of medicinal plant extracts/phytocompounds in human dendritic cells/monocytes Planta Medica
Published Papers (2009)
Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma Gene Therapy
Published Papers (2008)
Metabolomics for phytomedicine research and drug development Current Opinion in Chemical Biology
Published Papers (2008)
Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells BMC Genomics
Published Papers (2008)
Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues Journal of Biomedical Science
Published Papers (2007)
Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var formosana Tetrahedron Letters
Published Papers (2007)
Inhibition of tumor necrosis factor-alpha through selective blockade of pre-mRNA splicing by shikonin Molecular Pharmacology
Published Papers (2007)
A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma Cancer Research
Published Papers (2007)
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus Journal of Medicinal Chemistry
Published Papers (2006)
DNA vaccination against foot-and-mouth disease via electroporation: Study of molecular approaches for enhancing VP1 antigenicity. The Journal of Gene Medicine
Published Papers (2006)
Caffeic acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse Carcinogenesis
Published Papers (2006)
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study Genomics
Published Papers (2005)
A glycine-rich protein gene family predominantly expressed in tomato roots, but not in leaves and ripe fruit Plant Science
Published Papers (2005)
Comparative studies of the capsid precursor polypeptide P1 and the capsid protein VP1 cDNA vectors for DNA vaccination against foot-and-mouth diseases virus The Journal of Gene Medicine
Published Papers (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance Biochemistry
Published Papers (2005)
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin British Journal of Pharmacology
Published Papers (2004)
Molecular strategies for improving cytokine transgene expression in normal and malignant tissues Gene Therapy
Published Papers (2004)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo Journal of Biological Chemistry
Published Papers (2004)
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells Journal of Biomedical Science
Published Papers (2004)
Expression of bioactive human interferon-gamma protein in transgenic rice suspension cells Transgenic Research
Published Papers (2004)
Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus Journal of Biomedical Science
Published Papers (2004)
Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases Transgenic Research
Published Papers (2003)
Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing Journal of Genetics and Molecular Biology
Published Papers (2003)
In silico identification and phylogenetic analysis of putative plant arylalkylamine N-acetyl-transferase J Genet Mol Biol
Published Papers (2003)
Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica Journal of Agricultural and Food Chemistry
Published Papers (2003)
The sweet pepper ferredoxin-like protein (pflp) conferred resistance against soft rot disease in Oncidium orchid Transgenic Research
Published Papers (2003)
Agrobacterium tumefaciens-mediated transformation of an Oncidium orchid Plant Cell Reports
Published Papers (2003)
Tissue array transgene expression system for the evolution of effect of medicinal herbs on wound-healing Journal of Genetics and Molecular Biology
Published Papers (2003)
In Silico identification and phylogenetic analysis of an unique GNAT-type of acetyltransferases in plants Journal of Genetics and Molecular Biology
Published Papers (2002)
Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata Journal of Agricultural and Food Chemistry
Published Papers (2002)
Direct gene transfer and vaccination via skin transfection using a gene gun Methods in Molecular Medicine
Published Papers (2002)
Profiling and characterization antioxidant activities in Anoectochilus formosanus hayata Journal of Agricultural and Food Chemistry
Published Papers (2002)
Relative promoter strengths in four human prostate cancer cell lines evaluated by particle bombardment-mediated gene transfer The Prostate
Published Papers (2002)
Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme Biochemistry
Published Papers (2002)
Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model Molecular Cancer Therapeutics
Published Papers (2002)
Immunization by particle-mediated transfer of the granulocyte-macrophage colony-stimulating factor gene into autologous tumor cells in melanoma or sarcoma patients: report of a phase I/IB study Human Gene Therapy
Published Papers (2002)
Fas-Fas ligand signaling pathway mediates an interleukin-12-induced rejection of a murine prostate tumor system The Prostate
Published Papers (2001)
Truncated glucanase with enhanced activity and method for making the same US and ROC patent
Published Papers (2001)
Interleukin-12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer Human Gene Therapy
Published Papers (2001)
Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor Clinical Cancer Research
Published Papers (2001)
Antioxidant activity of extracts from Acacia confusa bark and heartwood Journal of Agricultural and Food Chemistry
Published Papers (2000)
The use of particle-mediated gene transfer for the study of promoter activity in somatic tissues Methods in Molecular Biology
Published Papers (2000)
Regulation of cell proliferation, gene expression, production ofcytokines, and cell cycle progression in primary human T lymphocytes b Mol Pharmacol
Published Papers (2000)
Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism Cancer Gene Therapy
Published Papers (2000)
Regulation of cell proliferation, gene expression, production of cytokines, and cell cycle progression in primary human T lymphocytes by piperlactam S isolated from Piper kadsura Molecular Pharmacology
Published Papers (1999)
Preclinical development of human granulocyte-macrophage colony-stimulatingfactor-transfected melanoma cell vaccine using established canine cel Cancer Gene Therapy
Published Papers (1999)
Inhibition of tumor growth in Lewis lung carcinoma in mice by combination of mIL-12 and IL-18 cDNA Am J Respir Crit Care Med
Published Papers (1999)
Gene gun-mediated IL-12 gene therapy induces antitumor effects in theabsence of toxicity: a direct comparison with systemic IL-12 protei J Immunother
Published Papers (1999)
Preclinical development of human granulocyte-macrophage colony-stimulating factor-transfected melanoma cell vaccine using established canine cell lines and normal dogs Cancer Gene Therapy
Published Papers (1999)
Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy Journal of Immunotherapy
Published Papers (1999)
Interleukin-12 cDNA skin transfection potentiates human papillomavirus E6 DNA vaccine-induced antitumor immune response Cancer Gene Therapy
Published Papers (1999)
Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
