農生中心相片 點選關閉

Published Papers (2016)
Molecular basis of shikonin-induced immunogenic cell death: insights for developing cancer therapeutics
Receptors & Clinical Investigation
Published Papers (2016)
Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis
Nature Communications
Published Papers (2016)
Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1
Oncotarget
Published Papers (2016)
Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis
Scientific Reports
Published Papers (2015)
Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasi
PLoS One
Published Papers (2015)
Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells
Journal of Leukocyte Biology
Published Papers (2015)
Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components
Molecular Cancer
Published Papers (2015)
Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine
PLoS One
Published Papers (2014)
Tumor-associated antigen/IL-21-transduced dendritic cell vaccines enhance immunity and inhibit immunosuppressive cells in metastatic melanoma
Gene Therapy
Published Papers (2013)
The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing
Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Integration of different “-omics” technologies identifies inhibition of the IGF1R-Akt-mTOR signaling cascade involved in the cytotoxic effect of shikonin against leukemia cells
Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-induced Colitis in Mice
PLoS One
Published Papers (2013)
Therapeutic Applications of Herbal Medicines for Cancer Patients
Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Specific Dioscorea phytoextracts enhance potency of TCL-loaded DC-based cancer vaccine
Evidence-based Complementary and Alternative Medicine
Published Papers (2013)
Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008–2012
Marine Drugs
Published Papers (2012)
Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
J. Biomed. Sci.
Published Papers (2012)
Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin vai post-translational mechanisms
Journal of Nutritional Biochemistry
Published Papers (2012)
Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms
PLoS One
Published Papers (2012)
Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine
Cancer Immunology Immunotherapy
Published Papers (2011)
Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin
Journal of Biomedical Science
Published Papers (2011)
Dioscorea phytocompounds synergistically enhance interleukin-2-mediated murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo
Evidence-based Complementary and Alternative Medicine
Published Papers (2011)
Specific microtubule-depolymerizing agents augment effcacy of dendritic cell-based cancer vaccine
Journal of Biomedical Science
Published Papers (2011)
Interleukin-4 enhances trafficking and functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage
Experimental Cell Research
Published Papers (2010)
Cytotoxic C-35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica
Organic Letters
Published Papers (2010)
Anti-Inflammatory Plant Natural Products for Cancer Therapy
Planta Medica
Published Papers (2010)
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling
BMC Genomics
Published Papers (2010)
Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses
BMC Genomics
Published Papers (2010)
Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants
Journal of Nutritional Biochemistry
Published Papers (2009)
Protective immunity against porcine circovirus 2 in mice induced by a gene-based combination vaccination
The Journal of Gene Medicine
Published Papers (2009)
Functional genomics of immuno-modulatory activities of medicinal plant extracts/phytocompounds in human dendritic cells/monocytes
Planta Medica
Published Papers (2009)
Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma
Gene Therapy
Published Papers (2008)
Metabolomics for phytomedicine research and drug development
Current Opinion in Chemical Biology
Published Papers (2008)
Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells
BMC Genomics
Published Papers (2008)
Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues
Journal of Biomedical Science
Published Papers (2007)
Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var formosana
Tetrahedron Letters
Published Papers (2007)
Inhibition of tumor necrosis factor-alpha through selective blockade of pre-mRNA splicing by shikonin
Molecular Pharmacology
Published Papers (2007)
A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma
Cancer Research
Published Papers (2007)
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus
Journal of Medicinal Chemistry
Published Papers (2006)
DNA vaccination against foot-and-mouth disease via electroporation: Study of molecular approaches for enhancing VP1 antigenicity.
The Journal of Gene Medicine
Published Papers (2006)
Caffeic acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse
Carcinogenesis
Published Papers (2006)
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study
Genomics
Published Papers (2005)
A glycine-rich protein gene family predominantly expressed in tomato roots, but not in leaves and ripe fruit
Plant Science
Published Papers (2005)
Comparative studies of the capsid precursor polypeptide P1 and the capsid protein VP1 cDNA vectors for DNA vaccination against foot-and-mouth diseases virus
The Journal of Gene Medicine
Published Papers (2005)
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance
Biochemistry
Published Papers (2005)
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin
British Journal of Pharmacology
Published Papers (2004)
Molecular strategies for improving cytokine transgene expression in normal and malignant tissues
Gene Therapy
Published Papers (2004)
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo
Journal of Biological Chemistry
Published Papers (2004)
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells
Journal of Biomedical Science
Published Papers (2004)
Expression of bioactive human interferon-gamma protein in transgenic rice suspension cells
Transgenic Research
Published Papers (2004)
Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus
Journal of Biomedical Science
Published Papers (2004)
Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases
Transgenic Research
Published Papers (2003)
Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing
Journal of Genetics and Molecular Biology
Published Papers (2003)
In silico identification and phylogenetic analysis of putative plant arylalkylamine N-acetyl-transferase
J Genet Mol Biol
Published Papers (2003)
Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica
Journal of Agricultural and Food Chemistry
Published Papers (2003)
The sweet pepper ferredoxin-like protein (pflp) conferred resistance against soft rot disease in Oncidium orchid
Transgenic Research
Published Papers (2003)
Agrobacterium tumefaciens-mediated transformation of an Oncidium orchid
Plant Cell Reports
Published Papers (2003)
Tissue array transgene expression system for the evolution of effect of medicinal herbs on wound-healing
Journal of Genetics and Molecular Biology
Published Papers (2003)
In Silico identification and phylogenetic analysis of an unique GNAT-type of acetyltransferases in plants
Journal of Genetics and Molecular Biology
Published Papers (2002)
Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata
Journal of Agricultural and Food Chemistry
Published Papers (2002)
Direct gene transfer and vaccination via skin transfection using a gene gun
Methods in Molecular Medicine
Published Papers (2002)
Profiling and characterization antioxidant activities in Anoectochilus formosanus hayata
Journal of Agricultural and Food Chemistry
Published Papers (2002)
Relative promoter strengths in four human prostate cancer cell lines evaluated by particle bombardment-mediated gene transfer
The Prostate
Published Papers (2002)
Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme
Biochemistry
Published Papers (2002)
Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model
Molecular Cancer Therapeutics
Published Papers (2002)
Immunization by particle-mediated transfer of the granulocyte-macrophage colony-stimulating factor gene into autologous tumor cells in melanoma or sarcoma patients: report of a phase I/IB study
Human Gene Therapy
Published Papers (2002)
Fas-Fas ligand signaling pathway mediates an interleukin-12-induced rejection of a murine prostate tumor system
The Prostate
Published Papers (2001)
Truncated glucanase with enhanced activity and method for making the same
US and ROC patent
Published Papers (2001)
Interleukin-12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer
Human Gene Therapy
Published Papers (2001)
Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor
Clinical Cancer Research
Published Papers (2001)
Antioxidant activity of extracts from Acacia confusa bark and heartwood
Journal of Agricultural and Food Chemistry
Published Papers (2000)
The use of particle-mediated gene transfer for the study of promoter activity in somatic tissues
Methods in Molecular Biology
Published Papers (2000)
Regulation of cell proliferation, gene expression, production ofcytokines, and cell cycle progression in primary human T lymphocytes b
Mol Pharmacol
Published Papers (2000)
Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism
Cancer Gene Therapy
Published Papers (2000)
Regulation of cell proliferation, gene expression, production of cytokines, and cell cycle progression in primary human T lymphocytes by piperlactam S isolated from Piper kadsura
Molecular Pharmacology
Published Papers (1999)
Preclinical development of human granulocyte-macrophage colony-stimulatingfactor-transfected melanoma cell vaccine using established canine cel
Cancer Gene Therapy
Published Papers (1999)
Inhibition of tumor growth in Lewis lung carcinoma in mice by combination of mIL-12 and IL-18 cDNA
Am J Respir Crit Care Med
Published Papers (1999)
Gene gun-mediated IL-12 gene therapy induces antitumor effects in theabsence of toxicity: a direct comparison with systemic IL-12 protei
J Immunother
Published Papers (1999)
Preclinical development of human granulocyte-macrophage colony-stimulating factor-transfected melanoma cell vaccine using established canine cell lines and normal dogs
Cancer Gene Therapy
Published Papers (1999)
Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy
Journal of Immunotherapy
Published Papers (1999)
Interleukin-12 cDNA skin transfection potentiates human papillomavirus E6 DNA vaccine-induced antitumor immune response
Cancer Gene Therapy
Published Papers (1999)
Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Research Findings (2015)
Developing ex-vivo 3D mammary tumor/organoid culture system for evaluating interactive immune check point molecular and cellular activities in tumor stromal microenvironment
Research Findings (2013)
Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice
Research Findings (2012)
Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms.
Research Findings (2012)
Dietary Administration of Scallion Extract Effectively Inhibits Colorectal Tumor Growth: Cellular and Molecular Mechanisms in Mice.
Research Findings (2011)
Interleukin-4 Enhances Trafficking and Functional Activities of GM-CSF-Stimulated Mouse Myeloid-Derived Dendritic Cells at Late Differentiation Stage
Research Findings (2010)
Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses.
Research Findings (2010)
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling
Research Findings (2009)
Method for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of dioscorea
Research Findings (2009)
Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma
Research Findings (2008)
Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells
Research Findings (2004)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies
Research Findings (2002)
Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies
Honors and Awards to ABRC Scientists (2014-10)
台灣生醫暨生農產業選秀大賽 生農組 潛力新秀獎
Honors and Awards to ABRC Scientists (2006)
Fellow of the American Association for the Advancement of Science (AAAS)
Issued Patents
預防和治療腸道發炎疾病之蟛蜞菊屬的植物萃取物及其用途
Taiwan TWI 491398
溫致群,蕭培文,黃文經Wen-ChingHuang,黃郁婷Yuh-TingHuang,林文晴Wen-ChingLin,楊寧蓀
Issued Patents
提供針對第二型豬環狀病毒之保護性免疫力之疫苗組合物與套組 Vaccine composition and kit providing protective immnuity against procine circovirus 2
Taiwan I367256
KandanAravindaram,楊寧蓀,郭村勇
Issued Patents
提供針對第二型豬環狀病毒之保護性免疫力之疫苗組合物及套組
Taiwan TW I 367256
KandanAravindaram,楊寧蓀,郭村勇
Issued Patents
趨化酵素RANTES與腫瘤相關抗原在治療及/或預防癌症之特殊療程上的應用
Taiwan TW I 365750
甘丹兒,楊寧蓀
Issued Patents
Treatment of Cancer and Inflammatory Disorder Treatment of Cancer and Inflammatory Disorder
USA-regular US8048455
徐麗芬,侯珈禎,吳志鴻,陳奕平,王升陽,黃啟彰,楊寧蓀
Issued Patents
具抗癌及抗發炎活性之萃取物及半乳糖脂之組合物
Taiwan I347192
徐麗芬,侯珈禎,王升陽,吳志鴻,陳奕平,黃啟彰,楊寧蓀
Issued Patents
山藥萃取物
Taiwan TW I 345471
楊寧蓀,徐麗芬,辛哈約克,蘇佩芬,李青晉
Issued Patents
Discorea extract
USA-regular US7,972,645
楊寧蓀,蘇佩芬,王正方
Issued Patents
產生類病毒微粒之高產率轉殖基因哺乳動物表現系統
Taiwan TW I 340166
蕭培文,楊寧蓀,黃銓珍,林恩豪
Issued Patents
CANCER AND INFLAMMATORY DISORDER TREATMENT
USA-regular US7547455
徐麗芬,侯珈禎,王升陽,吳志鴻,陳奕平,黃啟彰,楊寧蓀
Issued Patents
Truncated 1, 3-1,4-b-d-glucanase
USA-regular 7527958
徐麗芬,陳瑞麟,楊寧蓀
Issued Patents
Dioscorea Extracts
USA-regular 7419690
楊寧蓀,徐麗芬,辛哈約克,蘇佩芬,李青晉
Issued Patents
Truncated 1, 3-1,4-b-d-glucanase
USA-regular US 7,037,696 B1
徐麗芬,陳瑞麟,楊寧蓀
Issued Patents
提高比活性及熱耐受性之截短型沙斯諾金纖維分解菌1,3-1,4-b-D-葡聚醣酵素
Taiwan 發明第201683號
徐麗芬,陳瑞麟,楊寧蓀
";