Transgene-free CRISPR/Cas9-mediated gene editing through protoplast-to-plant regeneration enhances active compounds in Salvia miltiorrhiza. Plant biotechnology journal
Published Papers (2024)
Functional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp. Scientific reports
Published Papers (2024)
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies. Natural product reports
Published Papers (2023)
Metabolomic Analysis Demonstrates the Impacts of Polyketide Synthases PKS14 and PKS15 on the Production of Beauvericins, Bassianolide, Enniatin A, and Ferricrocin in Entomopathogen Beauveria bassiana. Metabolites
Published Papers (2023)
A Novel Phytogenic Formulation, EUBIO-BPSG, as a Promising One Health Approach to Replace Antibiotics and Promote Reproduction Performance in Laying Hens. Bioengineering (Basel, Switzerland)
Published Papers (2023-04-24)
In situ spatiotemporal mapping of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitor in pineapple (Ananas comosus) fruit tissue by MALDI mass spectrometry imaging Frontiers in Natural Products
Published Papers (2023-03-06)
Chemo‐ and Regioselective Construction of Functionalized Isocoumarin, Flavone, and Isoquinolinedione via a One‐pot Reaction of o ‐Quinol Acetate and Soft Nucleophiles ADVANCED SYNTHESIS & CATALYSIS
Published Papers (2022)
Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference. Journal of Food and Drug Analysis
Published Papers (2022)
Exploring the relationship between metabolite composition and the cold/hot properties ascribed in traditional Chinese medicine by mass spectral molecular networking–a pilot study Journal of Food and Drug Analysis
Published Papers (2022)
Microbial polyketides and their roles in insect virulence: from genomics to biological functions. Natural product reports
Published Papers (2022)
Surface-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (SALDI-IMS)-Based Detection of Vinca Alkaloids Distribution in the Petal of Madagascar Periwinkle. Methods in molecular biology (Clifton, N.J.)
Published Papers (2022)
Surfactin secreted by Bacillus amyloliquefaciens Ba01 is required to combat Streptomyces scabies causing potato common scab. Frontiers in plant science
Published Papers (2022)
Transcriptome of Nosema ceranae and Upregulated Microsporidia Genes during Its Infection of Western Honey Bee (Apis mellifera). Insects
Published Papers (2022)
Untargeted LC-MS/MS-Based Multi-Informative Molecular Networking for Targeting the Antiproliferative Ingredients in Tetradium ruticarpum Fruit. MOLECULES
Honors and Awards to ABRC Scientists (2022-10)
111年優秀天然藥物學術論文獎
Published Papers (2022)
Rhizospheric plant-microbe synergistic interactions achieve efficient arsenic phytoextraction by Pteris vittata. Journal of hazardous materials
Published Papers (2022)
Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors. Communications biology
Published Papers (2022)
Evaluation of the Antifungal Activities of Photorhabdus akhurstii and Its Secondary Metabolites against Phytopathogenic Colletotrichum gloeosporioides. Journal of fungi (Basel, Switzerland)
Published Papers (2018)
Genome mining of Streptomyces xinghaiensis NRRL B-24674(T) for the discovery of the gene cluster involved in anticomplement activities and detection of novel xiamycin analogs Applied microbiology and biotechnology
Published Papers (2018)
Exploration of Fungal Metabolic Interactions Using Imaging Mass Spectrometry on Nanostructured Silicon Journal of Natural Products
Published Papers (2018)
Biological control of potato common scab by Bacillus amyloliquefaciens Ba01 PloS one
Published Papers (2018)
Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa Marine Drugs
Published Papers (2018)
A piezo-ring-on-chip microfluidic device for simple and low-cost mass spectrometry interfacing The Analyst
Published Papers (2018)
A polysaccharide derived from Trichosporon sp. culture strongly primes plant resistance to viruses Molecular plant-microbe interactions : MPMI
Published Papers (2017)
Imaging mass spectrometry for metabolites: technical progress, multimodal imaging, and biological interactions Wiley Interdisciplinary Reviews-Systems Biology and Medicine
Published Papers (2017)
Bacillus Classification Based on Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry-Effects of Culture Conditions Scientific reports
Published Papers (2017)
Butyrolactones and Diketopiperazines from Marine Microbes: Inhibition Effects on Dengue Virus Type 2 Replication Planta Medica
Published Papers (2016)
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking Nature biotechnology
Published Papers (2016)
Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry: environment stability and activation by simple vacuum oven desiccation The Analyst
Published Papers (2016)
Involvement of type VI secretion system in secretion of iron chelator pyoverdine in Pseudomonas taiwanensis Scientific reports
Published Papers (2016)
Clarification of the Antagonistic Effect of the Lipopeptides Produced by Bacillus amyloliquefaciens BPD1 against Pyricularia oryzae via In Situ MALDI-TOF IMS Analysis Molecules
Published Papers (2015)
Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach. Scientific reports
Published Papers (2015)
Rapid identification of haloarchaea and methanoarchaea using the matrix assisted laser desorption/ionization time-of-flight mass spectrometry Scientific reports
Published Papers (2015)
New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression Organic letters
Published Papers (2015)
Avenaciolides: potential MurA-targeted inhibitors against peptidoglycan biosynthesis in methicillin-resistant Staphylococcus aureus (MRSA) Journal of the American Chemical Society
Published Papers (2014)
Microbiota of healthy corals are active against fungi in a light-dependent manner ACS chemical biology
Published Papers (2014)
Characterization of the flocculating agent from the spontaneously flocculating microalga Chlorella vulgaris JSC-7 Journal of bioscience and bioengineering
Published Papers (2014)
Bringing microbial interactions to light using imaging mass spectrometry Natural product reports
Published Papers (2014)
Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba Archives of microbiology
Published Papers (2013)
Polyenylpyrrole Derivatives Inhibit NLRP3 Inflammasome Activation and Inflammatory Mediator Expression by Reducing Reactive Oxygen Species Production and Mitogen-Activated Protein Kinase Activation PloS one
Published Papers (2013)
Generation of Reactive Oxygen Species by Polyenylpyrroles Derivatives Causes DNA Damage Leading to G2/M Arrest and Apoptosis in Human Oral Squamous Cell Carcinoma Cells PLoS One
Published Papers (2013)
Characterization of flocculating agent from the self-flocculating microalga Scenedesmus obliquus AS-6-1 for efficient biomass harvest Bioresource Technology
Published Papers (2012)
Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells Journal of Agricultural and Food Chemistry
Published Papers (2012)
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes Journal of proteomics
Published Papers (2012)
Asperjinone, a Nor-Neolignan, and Terrein, a Suppressor of ABCG2-Expressing Breast Cancer Cells, from Thermophilic Aspergillus terreus Journal of Natural Products
Published Papers (2011)
Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4 The Journal of biological chemistry
Published Papers (2011)
Structure and function of glycolipids in thermophilic bacteria Advances in Experimental Medicine and Biology
Published Papers (2011)
Sequencing cyclic peptides by multistage mass spectrometry Proteomics
Published Papers (2011)
A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2 The Journal of biological chemistry
Published Papers (2011)
A mass spectrometry-guided genome mining approach for natural product peptidogenomics Nature chemical biology
Published Papers (2010)
Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis Journal of Medicinal Chemistry
Published Papers (2010)
Structural variation of glycolipids from Meiothermus taiwanensis ATCC BAA-400 under different growth temperatures Organic & biomolecular chemistry
Published Papers (2010)
Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis Proceedings of the National Academy of Sciences of the United States of America
Published Papers (2010)
Acetogenin and prenylated flavonoids from Helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by neutrophils Planta Medica
Published Papers (2009)
Translating metabolic exchange with imaging mass spectrometry Nature chemical biology
Published Papers (2009)
Marinopyrrole A target elucidation by acyl dye transfer Journal of the American Chemical Society
Published Papers (2009)
Imaging mass spectrometry of natural products Natural product reports
Published Papers (2009)
Discovery of new natural products by intact-cell mass spectrometry and LC-SPE-NMR: malbranpyrroles, novel polyketides from thermophilic fungus Malbranchea sulfurea Chemistry-A European Journal
Published Papers (2009)
Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica Journal of Natural Products
Published Papers (2008)
TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria Glycoconjugate Journal
Published Papers (2008)
Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways Journal of Agricultural and Food Chemistry
Published Papers (2008)
New cyclic peptides from the seeds of Annona squamosa L and their anti-inflammatory activities Journal of Agricultural and Food Chemistry
Published Papers (2008)
Mono-tetrahydrofuran annonaceous acetogenins from Annona squamosa as cytotoxic agents and calcium ion chelators Journal of Natural Products
Published Papers (2008)
Cyclopeptides with anti-inflammatory activity from seeds of Annona montana Journal of Natural Products
Published Papers (2007)
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors Bioorganic & medicinal chemistry
Published Papers (2007)
Synthesis of a tetrasaccharide glycosyl glycerol Precursor to glycolipids of Meiothermus taiwanensis ATCC BAA-400 The Journal of organic chemistry
Published Papers (2007)
Cytotoxic withanolides from Tubocapsicum anomalum Journal of Natural Products
Published Papers (2007)
Cytotoxic sesquiterpene lactones from Pseudoelephantopus spicatus Journal of Natural Products
Published Papers (2007)
Cytotoxic polyketides containing tetramic acid moieties isolated from the fungus Myceliophthora Thermophila: elucidation of the relationship between cytotoxicity and stereoconfiguration CHEMISTRY-A EUROPEAN JOURNAL
Published Papers (2006)
Structural elucidation of phosphoglycolipids from strains of the bacterial thermophiles Thermus and Meiothermus Journal of lipid research
Published Papers (2006)
New sesquiterpene lactones from the aerial parts of Pseudoelephantopus spicatus Chemical & pharmaceutical bulletin
Published Papers (2006)
New constituents from stems of Goniothalamus amuyon Chemical & pharmaceutical bulletin
Published Papers (2006)
Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var pendula Planta Medica
Published Papers (2005)
Squadinorside, A Novel 7,9′-Dinorlignan Skeleton from the Stems of Annona squamosa HELVETICA CHIMICA ACTA
Published Papers (2005)
An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions Planta Medica
Published Papers (2004)
Two Sesquiterpene-coumarins from the Roots of Ferula marmarica HETEROCYCLES
Published Papers (2004)
Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils Planta Medica
Published Papers (2004)
Annosqualine, a Novel Skeleton Alkaloid from the Stems of Annona squamosa HELVETICA CHIMICA ACTA
Published Papers (2003)
Total Synthesis of 3,4-Dihydrobenzo[h]quinazolin-4-one and Structural Elucidation of Perlolidine and Samoquasine A TETRAHEDRON LETTERS
Published Papers (2003)
Secoiridoid glycoside and alkaloid constituents of Hydrangea chinensis Journal of Natural Products
Published Papers (2003)
Cytotoxic styrylpyrones from Goniothalamus amuyon Journal of Natural Products
Published Papers (2003)
Chemical and Pharmacological Studies of ent-Kaurane Diterpenoids from Annonaceae Chinese Pharmaceutical Journal
Published Papers (2003)
A Natural Pyrone Derivative from the Woods of Polyalthia Longifolia var Pendula Chinese Pharmaceutical Journal
Published Papers (2002)
New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa Journal of Natural Products
Published Papers (2021)
The potential biocontrol agent Paenibacillus polymyxa TP3 produces fusaricidin-type compounds involved in the antagonism against gray mold pathogen Botrytis cinerea Phytopathology
Published Papers (2021)
The brown root rot fungus Phellinus noxius affects microbial communities in different root-associated niches of Ficus trees Environmental microbiology
Published Papers (2021)
Visualizing Vinca Alkaloids in the Petal of Catharanthus roseus Using Functionalized Titanium Oxide Nanowire Substrate for Surface-assisted Laser Desorption/ionization Imaging Mass Spectrometry Plant J
Published Papers (2021)
Targeted Isolation of Xenicane Diterpenoids from Taiwanese Soft Coral Asterospicularia laurae Marine Drugs
Published Papers (2021)
Specific Inactivation of an Anti-fungal Bacterial Siderophore by a Fungal Plant Pathogen ISME J.
Published Papers (2021)
Polyketides with Anti-neuroinflammatory Activity from Theissenia cinerea Journal of Natural Products
Published Papers (2021)
Natural polyketide 6-pentyl-2H-pyrone-2-one and its synthetic analogues efficiently prevent marine biofouling Biofouling
Published Papers (2021)
Natural alkaloid tryptanthrin exhibits novel anticryptococcal activity Medical Mycology
Published Papers (2021)
Integrated Omics Strategy Reveals Cyclic Lipopeptides Empedopeptins from Massilia sp YMA4 and Their Biosynthetic Pathway Marine Drugs
Published Papers (2020)
Whole Genome Sequencing and Tn5-Insertion Mutagenesis of Pseudomonas taiwanensis CMS to Probe Its Antagonistic Activity Against Rice Bacterial Blight Disease International Journal of Molecular Sciences
Published Papers (2019)
Efficient identification of fungal antimicrobial principles by tandem MS and NMR database Journal of food and drug analysis
Research Findings (2020)
Specific inactivation of an antifungal bacterial siderophore by a fungal plant pathogen
Honors and Awards to ABRC Scientists (2016-11)
吳大猷先生紀念獎
Honors and Awards to ABRC Scientists (2014)
In the Analytical Scientist’s 2014 Top 40 Under 40 list of researchers
Honors and Awards to ABRC Scientists (2013)
Li Foundation Heritage Prize for “Excellence in Creativity”
