Published Papers
| Published Papers (2016) Molecular basis of shikonin-induced immunogenic cell death: insights for developing cancer therapeutics more Receptors & Clinical Investigation | |
| Published Papers (2016) Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis more Nature Communications | |
| Published Papers (2016) Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1 more Oncotarget | |
| Published Papers (2016) Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis more Scientific Reports | |
| Published Papers (2015) Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasi more PLoS One | |
| Published Papers (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells more Journal of Leukocyte Biology | |
| Published Papers (2015) Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components more Molecular Cancer | |
| Published Papers (2015) Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine more PLoS One | |
| Published Papers (2014) Tumor-associated antigen/IL-21-transduced dendritic cell vaccines enhance immunity and inhibit immunosuppressive cells in metastatic melanoma more Gene Therapy | |
| Published Papers (2013) The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2013) Integration of different “-omics” technologies identifies inhibition of the IGF1R-Akt-mTOR signaling cascade involved in the cytotoxic effect of shikonin against leukemia cells more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2013) Dietary Uptake of Wedelia chinensis Extract Attenuates Dextran Sulfate Sodium-induced Colitis in Mice more PLoS One | |
| Published Papers (2013) Therapeutic Applications of Herbal Medicines for Cancer Patients more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2013) Specific Dioscorea phytoextracts enhance potency of TCL-loaded DC-based cancer vaccine more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2013) Anti-inflammatory activities of natural products isolated from soft corals of Taiwan between 2008–2012 more Marine Drugs | |
| Published Papers (2012) Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES more J. Biomed. Sci. | |
| Published Papers (2012) Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin vai post-translational mechanisms more Journal of Nutritional Biochemistry | |
| Published Papers (2012) Dietary administration of scallion extract effectively inhibits colorectal tumor growth: Cellular and molecular mechanisms more PLoS One | |
| Published Papers (2012) Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine more Cancer Immunology Immunotherapy | |
| Published Papers (2011) Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin more Journal of Biomedical Science | |
| Published Papers (2011) Dioscorea phytocompounds synergistically enhance interleukin-2-mediated murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo more Evidence-based Complementary and Alternative Medicine | |
| Published Papers (2011) Specific microtubule-depolymerizing agents augment effcacy of dendritic cell-based cancer vaccine more Journal of Biomedical Science | |
| Published Papers (2011) Interleukin-4 enhances trafficking and functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage more Experimental Cell Research | |
| Published Papers (2010) Cytotoxic C-35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica more Organic Letters | |
| Published Papers (2010) Anti-Inflammatory Plant Natural Products for Cancer Therapy more Planta Medica | |
| Published Papers (2010) Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling more BMC Genomics | |
| Published Papers (2010) Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses more BMC Genomics | |
| Published Papers (2010) Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants more Journal of Nutritional Biochemistry | |
| Published Papers (2009) Protective immunity against porcine circovirus 2 in mice induced by a gene-based combination vaccination more The Journal of Gene Medicine | |
| Published Papers (2009) Functional genomics of immuno-modulatory activities of medicinal plant extracts/phytocompounds in human dendritic cells/monocytes more Planta Medica | |
| Published Papers (2009) Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma more Gene Therapy | |
| Published Papers (2008) Metabolomics for phytomedicine research and drug development more Current Opinion in Chemical Biology | |
| Published Papers (2008) Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells more BMC Genomics | |
| Published Papers (2008) Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues more Journal of Biomedical Science | |
| Published Papers (2007) Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var formosana more Tetrahedron Letters | |
| Published Papers (2007) Inhibition of tumor necrosis factor-alpha through selective blockade of pre-mRNA splicing by shikonin more Molecular Pharmacology | |
| Published Papers (2007) A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma more Cancer Research | |
| Published Papers (2007) Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus more Journal of Medicinal Chemistry | |
| Published Papers (2006) DNA vaccination against foot-and-mouth disease via electroporation: Study of molecular approaches for enhancing VP1 antigenicity. more The Journal of Gene Medicine | |
| Published Papers (2006) Caffeic acid suppresses UVB radiation-induced expression of interleukin-10 and activation of mitogen-activated protein kinases in mouse more Carcinogenesis | |
| Published Papers (2006) Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study more Genomics | |
| Published Papers (2005) A glycine-rich protein gene family predominantly expressed in tomato roots, but not in leaves and ripe fruit more Plant Science | |
| Published Papers (2005) Comparative studies of the capsid precursor polypeptide P1 and the capsid protein VP1 cDNA vectors for DNA vaccination against foot-and-mouth diseases virus more The Journal of Gene Medicine | |
| Published Papers (2005) A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance more Biochemistry | |
| Published Papers (2005) Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin more British Journal of Pharmacology | |
| Published Papers (2004) Molecular strategies for improving cytokine transgene expression in normal and malignant tissues more Gene Therapy | |
| Published Papers (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo more Journal of Biological Chemistry | |
| Published Papers (2004) Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells more Journal of Biomedical Science | |
| Published Papers (2004) Expression of bioactive human interferon-gamma protein in transgenic rice suspension cells more Transgenic Research | |
| Published Papers (2004) Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus more Journal of Biomedical Science | |
| Published Papers (2004) Transgenic tomato plants expressing the Arabidopsis NPR1 gene display enhanced resistance to a spectrum of fungal and bacterial diseases more Transgenic Research | |
| Published Papers (2003) Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing more Journal of Genetics and Molecular Biology | |
| Published Papers (2003) In silico identification and phylogenetic analysis of putative plant arylalkylamine N-acetyl-transferase more J Genet Mol Biol | |
| Published Papers (2003) Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica more Journal of Agricultural and Food Chemistry | |
| Published Papers (2003) The sweet pepper ferredoxin-like protein (pflp) conferred resistance against soft rot disease in Oncidium orchid more Transgenic Research | |
| Published Papers (2003) Agrobacterium tumefaciens-mediated transformation of an Oncidium orchid more Plant Cell Reports | |
| Published Papers (2003) Tissue array transgene expression system for the evolution of effect of medicinal herbs on wound-healing more Journal of Genetics and Molecular Biology | |
| Published Papers (2003) In Silico identification and phylogenetic analysis of an unique GNAT-type of acetyltransferases in plants more Journal of Genetics and Molecular Biology | |
| Published Papers (2002) Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata more Journal of Agricultural and Food Chemistry | |
| Published Papers (2002) Direct gene transfer and vaccination via skin transfection using a gene gun more Methods in Molecular Medicine | |
| Published Papers (2002) Profiling and characterization antioxidant activities in Anoectochilus formosanus hayata more Journal of Agricultural and Food Chemistry | |
| Published Papers (2002) Relative promoter strengths in four human prostate cancer cell lines evaluated by particle bombardment-mediated gene transfer more The Prostate | |
| Published Papers (2002) Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme more Biochemistry | |
| Published Papers (2002) Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model more Molecular Cancer Therapeutics | |
| Published Papers (2002) Immunization by particle-mediated transfer of the granulocyte-macrophage colony-stimulating factor gene into autologous tumor cells in melanoma or sarcoma patients: report of a phase I/IB study more Human Gene Therapy | |
| Published Papers (2002) Fas-Fas ligand signaling pathway mediates an interleukin-12-induced rejection of a murine prostate tumor system more The Prostate | |
| Published Papers (2001) Truncated glucanase with enhanced activity and method for making the same more US and ROC patent | |
| Published Papers (2001) Interleukin-12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer more Human Gene Therapy | |
| Published Papers (2001) Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor more Clinical Cancer Research | |
| Published Papers (2001) Antioxidant activity of extracts from Acacia confusa bark and heartwood more Journal of Agricultural and Food Chemistry | |
| Published Papers (2000) The use of particle-mediated gene transfer for the study of promoter activity in somatic tissues more Methods in Molecular Biology | |
| Published Papers (2000) Regulation of cell proliferation, gene expression, production ofcytokines, and cell cycle progression in primary human T lymphocytes b more Mol Pharmacol | |
| Published Papers (2000) Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism more Cancer Gene Therapy | |
| Published Papers (2000) Regulation of cell proliferation, gene expression, production of cytokines, and cell cycle progression in primary human T lymphocytes by piperlactam S isolated from Piper kadsura more Molecular Pharmacology | |
| Published Papers (1999) Preclinical development of human granulocyte-macrophage colony-stimulatingfactor-transfected melanoma cell vaccine using established canine cel more Cancer Gene Therapy | |
| Published Papers (1999) Inhibition of tumor growth in Lewis lung carcinoma in mice by combination of mIL-12 and IL-18 cDNA more Am J Respir Crit Care Med | |
| Published Papers (1999) Gene gun-mediated IL-12 gene therapy induces antitumor effects in theabsence of toxicity: a direct comparison with systemic IL-12 protei more J Immunother | |
| Published Papers (1999) Preclinical development of human granulocyte-macrophage colony-stimulating factor-transfected melanoma cell vaccine using established canine cell lines and normal dogs more Cancer Gene Therapy | |
| Published Papers (1999) Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy more Journal of Immunotherapy | |
| Published Papers (1999) Interleukin-12 cDNA skin transfection potentiates human papillomavirus E6 DNA vaccine-induced antitumor immune response more Cancer Gene Therapy | |
| Published Papers (1999) Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA more PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
Site Navigation
| Issued Patents (6) |
| Published Papers (81) |
| Research Findings (12) |
| Honors and Awards to ABRC Scientists (2) |
Site Navigation — Select a Researcher
