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Published Papers

Umam Khotibul, Feng Ching-Shan, Yang Greta, Tu Ping-Chen, Lin Chih-Yu, Yang Meng-Ting, Kuo Tien-Fen, Yang Wen-Chin, Tran Nguyen Minh Hieu (2023) Phytochemistry, Pharmacology and Mode of Action of the Anti-Bacterial Artemisia Plants. Bioengineering, 10(6), 633
Tseng Hui-Ju, Chen Wen-Chu, Kuo Tien-Fen, Yang Greta, Feng Ching-Shan, Chen Hui-Ming, Chen Tzung-Yan, Lee Tsung-Han, Yang Wen-Chin, Tsai Keng-Chang, Huang Wei-Jan (2023) Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice. Cellular and Molecular Life Sciences, 80(4), 101
Yeh Chia-Min, Sun Yun-Ya, Chen Ting-Yu, Hung Yu, Lee Guan-Chiun, Yang Wen-Chin, Lin Yenshou (2023) Early Life Exposure to C16-Ceramide Improves Learning and Short-Term Memory Behavior during Adulthood in Mice. ACS Chemical Neuroscience, 14, 1369-1378
Tran Nguyen Minh Hieu, Kuo Tien-Fen, Lin Wen-Yu, Peng Tzu-Chia, Yang Greta, Lin Chih-Yu, Chang Ting-Hsiang, Yang Yu-Liang, Ho Cheng-Hsun, Ou Bor-Rung, Yang Chu-Wen, Liang Yu-Chuan, Yang Wen-Chin (2023) A Novel Phytogenic Formulation, EUBIO-BPSG, as a Promising One Health Approach to Replace Antibiotics and Promote Reproduction Performance in Laying Hens. Bioengineering, 10(3), 346
Wang Wei-Chieh, Chung Hsin-Hsiang, Dutkiewicz Ewelina P., Wong Jhih-Ying, Yang Wen-Chin, Chang Cicero Lee-Tian, Hsu Cheng-Chih (2021) On-Site Diagnosis of Poultry Coccidiosis by a Miniature Mass Spectrometer and Machine Learning. ACS Agricultural Science & Technology,
Yang Meng-Ting, Lin Yi-Xian, Yang Greta, Kuo Tien-Fen, Liang Yu-Chen, Lee Tsung-Han, Chang Cicero Lee-Tian, Yang Wen-Chin (2021) Functional and Mechanistic Studies of Two Anti-coccidial Herbs, Bidens pilosa and Artemisia indica. Planta Medica,
73.Chen, T.Y. Yang, C.Y., Yang, M.T., Kuo, T.F., Chang, C.L.T., Chen, C.L., Chiu, C.F., Yu, Y.H., Yang, G., Lee, T.H., Yang, W.C.* (2021) Protein disulfide isomerase a4 promotes lung cancer development via the Stat3 pathway in stromal cells Clinical and Translational Medicine. Clinical and Translational Medicine,
Chuang Jen-Hua, Yang Wen-Chin, Lin Yenshou (2021) Glutamatergic Neurons Differentiated from Embryonic Stem Cells: An Investigation of Differentiation and Associated Diseases. International Journal of Molecular Sciences, 22(9), 4592
Yang Meng-Ting, Chang Wei-Hung, Kuo Tien-Fen, Shen Ming-Yi, Yang Chu-Wen, Tien Yin-Jing, Lai Bun-Yueh, Chen Yet-Ran, Chang Yi-Cheng, Yang Wen-Chin (2021) Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach. Frontiers in Endocrinology, 12, 641336
Chen Chen-Sheng, Pan Bo-Yi, Tsai Ping-Hsuan, Chen Fang-Yu, Yang Wen-Chin, Shen Ming-Yi (2021) Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling. International Journal of Molecular Sciences, 22(19), 10309
Kuo Tien‐Fen, Hsu Shuo‐Wen, Huang Shou‐Hsien, Chang Cicero Lee‐Tian, Feng Ching‐Shan, Huang Ming‐Guang, Chen Tzung‐Yan, Yang Meng‐Ting, Jiang Si‐Tse, Wen Tuan‐Nan, Yang Chun‐Yen, Huang Chung‐Yu, Kao Shu‐Huei, Tsai Keng‐Chang, Yang Greta, Yang Wen‐Chin (2021) Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy. EMBO Molecular Medicine, 13(10), e11668
Wang Jie-Sian, Tsai Ping-Hsuan, Tseng Kuo-Feng, Chen Fang-Yu, Yang Wen-Chin, Shen Ming-Yi (2021) Sesamol Ameliorates Renal Injury-Mediated Atherosclerosis via Inhibition of Oxidative Stress/IKKα/p53. Antioxidants, 10(10), 1519
Kuo Tien-Fen, Yang Greta, Chen Tzung-Yan, Wu Yueh-Chen, Minh Hieu Tran Nguyen, Chen Lin-Shyan, Chen Wen-Chu, Huang Ming-Guang, Liang Yu-Chuan, Yang Wen-Chin (2020) Bidens pilosa: Nutritional Value and Benefits for Metabolic Syndrome. eFood,
Yang Meng-Ting, Kuo Tien-Fen, Chung Kuo-Fang, Liang Yu-Chuan, Yang Chu-Wen, Lin Chih-Yu, Feng Ching-Shan, Chen Zeng-Weng, Lee Tsung-Han, Hsiao Chiao-Ling, Yang Wen-Chin (2020) Authentication, phytochemical characterization and anti-bacterial activity of twoArtemisiaspecies. Food Chemistry, 333 127458
Liang Yu-Chuan, Lin Chuan-Ju, Yang Cheng-Ying, Chen Yung-Hsiang, Yang Meng-Ting, Chou Fu-Shiuan, Yang Wen-Chin, Chang Cicero Lee-Tian (2020) Toxicity study of Bidens pilosa in animals. Journal of Traditional and Complementary Medicine, 10(2), 150-157
Apaya Maria Karmella, Kuo Tien-Fen, Yang Meng-Ting, Yang Greta, Hsiao Chiao-Ling, Chang Song-Bin, Lin Yenshou, Yang Wen-Chin (2020) Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential. Pharmacological Research, 156 104754
Yang, W.C., Yang, C.Y., Liang, Y.C., Li, W.Q., Chung, C.Y., Yang, M.T., Kuo, T.F., Lin, C.F., Liang, C.L., Chang, C.L.T. (2019) Anti-coccidial properties and mechanisms of an edible herb, Bidens pilosa, and its active compounds for coccidiosis. Scientific Reports, 9, 2896
Kuo Li-Chen, Song Yan-Qing, Yao Chien-An, Cheng Irene H., Chien Chiang-Ting, Lee Guan-Chiun, Yang Wen-Chin, Lin Yenshou* (2019) Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons. Journal of Agricultural and Food Chemistry, 67(1), 81-89
van der Touw, W, Kang, K., Luan, Y., Ma, G., Mai, S., Qin, L., Bian, G., Mungamuri, S. K., Zhang, R., Hu, H.M., Zhang, C.C., Aaronson, S.A., Feldmann, M., Yang, W.C., Chen, S.H.*, and Pan, P.Y. (2018) Glatiramer acetate enhances myeloid-derived suppressor cell function via recognition of paired Ig-like receptor B. JOURNAL OF IMMUNOLOGY, 201(6), 1727-1734
Bartolome, A.P., Villaseñor, I.M., Lin, Y.L., M. Libardo, D.J., Angeles-Boza, A.M., Yang, W.C. (2017) Cytotoxic property of Streptocaulon baumii extracts and their isolated compounds against different human cancer cell lines. Philippine Science Letters, 10(2), 89-97
Kuo T-F, Chen T-Y, Jiang S-T, Chen K-W, Chiang Y-M, Hsu Y-J, Liu Y-J, Chen H-M, Yokoyama K K, Tsai K-C, Yeh H-H, Chen Y-R, Yang M-T, Yang C-Y, Yang W-C* (2017) Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway. Oncogene, 36(39),5484-5496
Wei Wen-Chi, Lin Sheng-Yen, Lan Chun-Wen, Huang Yu-Chen, Lin Chih-Yu, Hsiao Pei-Wen, Chen Yet-Ran, Yang Wen-Chin, Yang Ning-Sun (2016) Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis. Scientific Reports, 6(1), 36663
Muthamilselvan, T., Kuo, T.F., Wu, Y.C., Yang W.C.* (2016) Herbal remedies for coccidiosis control: A review of plants, compounds and anticoccidial actions. Evidence-Based Complementary and Alternative Medicine, 2657981
Chang CL, Yang CY, Muthamilselvan T, Yang WC (2016) Field trial of medicinal plant, Bidens pilosa, against eimeriosis in broilers. Scientific reports, 6, 24692
Chung CY, Yang WC, Liang CL, Liu HY, Lai SK, Chang CL (2016) Cytopiloyne, a polyacetylenic glucoside from Bidens pilosa, acts as a novel anticandidal agent via regulation of macrophages. Journal of ethnopharmacology, 184, 72-80
Liang YC, Yang MT, Lin CJ, Chang CL, Yang WC (2016) Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARgamma pathways. Scientific reports, 6, 24285
Chang, C.L.T., , Chung, C.Y., Kuo, C.H., Kuo, T.F., Kuo, Yang, C.W.* and W.C. Yang, W. C.* (2016) Beneficial effect of Bidens pilosa on body weight gain, food conversion ratio, gut bacteria and coccidiosis in chickens. PLoS One, 11(1), e0146141
Chung Chih-Yao, Yang Wen-Chin, Liang Chih-Lung, Liu Hsien-Yueh, Lai Shih-Kai, Chang Cicero Lee-Tian (2016) Data on the effect of Cytopiloyne against Listeria monocytogenes infection in mice. Data in Brief, 7, 995-998
Chien, S.C., Wu, Y.C., Chen, Z.W., Yang, W.C.* (2015) Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes. Evidence-based Complementary and Alternative Medicine, 357357
Shiau, J.Y., Yin, S. Y., Chang, S. L., Hsu, Y. J., Chen, K. W., Kuo, T. F., Feng, C. S., Yang, N. S., Shyur, L. F. *, Yang, W. C.*, Wen, T. N.* (2015) Mechanistic Study of the Phytocompound, 2-β-D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches. Evidence-based Complementary and Alternative Medicine, 475610
Yang, W.C., Chang, C.L.T., Li, C.R., Nammi, S. And Cho, W.C.S. (2015) Complementary and Alternative Medicine for Diabetes 2014. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 685248
Yang WC, Tien YJ, Chung CY, Chen YC, Chiou WH, Hsu SY, Liu HY, Liang CL, Chang CL (2015) Effect of Bidens pilosa on infection and drug resistance of Eimeria in chickens. Research in veterinary science, 98, 74-81
Wei, W.C., Liu, C.P., Yang, W,C., Shyur, L.F. Sheu, J.H.,Chen, S.S., Yang, N.S.* (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells. JOURNAL OF LEUKOCYTE BIOLOGY, 97(6), 1071-1080
Hsieha, C.T.,Chuanga, J.H., Yang, W.C., Yin, Y., Lin, Y. (2014) Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle. Cellular Signalling, 26(7), 1400-1408
Yang WC (2014) Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic Plant L. Evidence-Based Complementary and Alternative Medicine, 2014, 698617
Yang WC, Ma G, Chen SH, Pan PY (2013) Polarization and reprogramming of myeloid-derived suppressor cells. Journal of molecular cell biology, 5(3), 207-209
Chang, C.L.T., Chen, Chen, Y.C., H.M., Yang, N.S., Yang, W.C. (2013) Natural cures for type 1 diabetes: A review of phytochemicals, Biological actions, and clinical potential. Current Medicinal Chemistry, 20(7), 899-907
Yang, W.C.* (2013) Myeloid-Derived Suppressor Cells in Autoimmune Diabetes: Their Anti-diabetic Potential and Mechanism. Journal of Diabetes & Metabolism, S12, 004
Chen YC, Tien YJ, Chen CH, Beltran FN, Amor EC, Wang RJ, Wu DJ, Mettling C, Lin YL, Yang WC (2013) Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling. BMC complementary and alternative medicine, 13, 45
Chang CL, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC (2013) Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evidence-Based Complementary and Alternative Medicine, 2013, 378657
Yang WC, Nammi S, Jeppesen PB, Cho WC (2013) Complementary and alternative medicine for diabetes. Evidence-Based Complementary and Alternative Medicine, 2013, 831068
Yang, W.C.* (2013) Botanical, Pharmacological, Phytochemical and Toxicological Aspects of the Anti-diabetic plant Bidens pilosa L. Evidence-based Complementary and Alternative Medicine, 2013, 698617
Bartolome AP, Villasenor IM, Yang WC (2013) Bidens pilosa L. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology.. Evidence-Based Complementary and Alternative Medicine, 2013, 340215
Chang, C.L.T, Liu, H.Y., Kuo, T.F., Hsu, Y.J., Shen, M.Y., Pan, C.Y. and Yang, W.C. (2013) Anti-diabetic effect and mode of action of cytopiloyne. Evidence-Based Complementary and Alternative Medicine, 685642
Chen HM, Wang PH, Chen SS, Wen CC, Chen YH, Yang WC, Yang NS (2012) Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine. Cancer Immunology Immunotherapy, 61(11), 1989-2002
Chen HM, Wang PH, Aravindaram K, Chen YH, Yu HH, Yang WC, Yang NS (2012) Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES. Journal of Biomedical Science, 19(1), 42
Liu HY, Chung CY, Yang WC, Liang CL, Wang CY, Chang CY, Chang CL (2012) Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice. Journal of veterinary science, 13(3), 245-252
Yang CW, Chang CL, Lee HC, Chi CW, Pan JP, Yang WC (2012) Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways. BMC complementary and alternative medicine, 12, 22
Shen MY, Lin YP, Yang BC, Jang YS, Chiang CK, Mettling C, Chen ZW, Sheu JR, Chang CL, Lin YL, Yang WC (2012) Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways. Evidence-Based Complementary and Alternative Medicine, 2012, 982396
Shen, M.Y., Lin, Y.P., Yang, B.C., Jang, Y.S., Chiang, C.K., Mettling, C., Chen, Z.W., Sheu, J.R., Chang, C.T.L.*, Lin, Y.L. *, and Yang, W.C.* (2012) Catenarin prevents type 1 diabetes in non-obese diabetic mice via inhibition of leukocyte migration involving the MEK6/p38 and MEK7/JNK pathways. Evidence-Based Complementary and Alternative Medicine, 982396
Shen MY, Liu YJ, Don MJ, Liu HY, Chen ZW, Mettling C, Corbeau P, Chiang CK, Jang YS, Li TH, Young P, Chang CL, Lin YL, Yang WC (2011) Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica. PloS one, 6(11), e27480
Kazłowska, K., Hsu, T., Hou, C.C., Yang, W.C.*, Tsai*, G.J. (2010) Anti-inflammatory properties of phenolic compounds and crude extract from Phorphyra dentata. Journal of Ethnopharmacology, 128(1),123-130
Li, T.H., Hou, C.C., Chang, C.T.L., Yang, W.C. (2010) Anti-hyperglycemic properties of crude extract and triterpenes from Poria cocos. Evidence-based Complementary and Alternative Medicine, 2010, 1-8
Pan, J.Z., Nakade, K., Huang, Y.C., Zhu, Z.W., Masuzaki, S., Hasegawa, H., Murata, T., Yoshiki, A., Yamaguch, N., Lee, C.H., Yang, W.C., Tsai, E.M., Obata Y., Yokoyama, K.K. (2010) Suppression of cell cycle progression by Jun dimerization protein 2 (JDP2) involves down-regulation of cyclin A2. ONCOGENE, 29(47), 6245-6256
Yin, B., M, G., Yen, C.Y., Zhou, Z., Wang, G.X., Divino, C.M., Casares, S., Chen, S.H.*,Yang, W.C.*, and Pan, P.Y.* (2010) Myeloid-derived suppressor cells prevent type 1 diabetes in murine models. JOURNAL OF IMMUNOLOGY, 185(10), 5828-5834
Chang, S.L., Chang, C.L.T., Huang, P.I., Tao, M.H., Yang, W.C. (2009) Role of Cybr, a cytohesin binder and regulator, in CD4+ T-cell function and host immunity. MOLECULAR IMMUNOLOGY, 46, 3218-3223
Y.J. Hsua, T.H. Lee, C.L.T.Chang, Y.T.Huang, W.C. Yang (2009) Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract. Journal of Ethnopharmacology, 122(2), 379-383
S.C.Chien, P. H. Young,Y.J.Hsu, C.H.Chen, T.H.Li, C.W. Yang, P. Marimuthu, L.F.Tsai and W.C. Yang (2009) Anti-diabetic properties of three common Bidens pilosa variants in Taiwan. PHYTOCHEMISTRY, 70(10), 1246-1254
許曉茹、莊大永、楊文欽、賴邦嶽 (2007) 咸豐草的功效. 科學發展, 417, 40-43
Chang, S.-L., Yeh, H.-H., Lin, Y.-S., Chiang, Y.-M., Wu, T.-K. and Yang, W.-C. * (2007) The effect of centaurein on interferon gamma expression and Listeria infection in mice. TOXICOLOGY AND APPLIED PHARMACOLOGY, 219(1), 54-61
S.L. Chang, Y.M. Chiang, C.L.T. Chang, H.H. Yeh, L.F. Shyur, Y.H. Kuo, T.K. Wu, Yang, W.C.* (2007) Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-g expression. Journal of Ethnopharmacology, 112, 232-236
Chang, C.-L.-T., Chang, S.-L., Lee, Y.-M., Chiang, Y.-M., Chuang, D.-Y., Kuo, H.-K. and Yang, W.-C.* (2007) Cytopiloyne, a Polyacetylenic Glucoside, Prevents Type 1 Diabetes in Non-obese Diabetic Mice. JOURNAL OF IMMUNOLOGY, 178, 6984-6993
Chiang, Y.-M., Cicero L.-T., Chang, S.-L., Yang, W.-C.*, and Shyur, L.-F.* (2007) Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. Journal of Ethnopharmacology, 110, 532-538
Wang, C.-Y., Chiao, M.-C., Yeh, P.-J., Hwang, W.-C., Hou, C.-C., Chien, S.-C., Yeh, K.-C., Yang, W.-C., Shyur, L.-F.* and Yang, N.-S.* (2006) Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based study. Genomics, 88(6), 801-808
C.L.T. Chang, H. K. Kuo, S. L. Chang, Y. M. Chiang, L. F. Shyur, T. H. Lee, W. M. Wu and W. C. Yang.個人網站'>W. C. Yang. (2005) The distinct effect of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice J Biomed Sci. Journal of Biomedical Science, 12(1), 79-89
Garçon F, Ghiotto M, Gérard A, Yang, W.-C. and Olive D, Nunès JA. (2004) The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule. EUROPEAN JOURNAL OF IMMUNOLOGY, 34. 1972-1980
Chang, S.-L., Chang, C. L.-T., Chiang, Y.-M., Hsieh, R.-H., Tzeng, C.-R., Wu, T.-K., Sytwu, H.-K., Shyur L.-F.* and Yang, W.-C.* (2004) Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice. Planta Medica, 70, 1045-1051
W. C. Yang, K. A. Ching, C. D. Tsoukas and L. J. Berg (2001) Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain. JOURNAL OF IMMUNOLOGY, 166, 387-395
W. C. Yang, Y. Collette, J. Nunes and D. Olive (2000) Tec kinases: a family with multiple roles in immunity. IMMUNITY, 12, 373-382
W. C. Yang, M. Ghiotto, R. Castellano, Y. Collette, N. Auphan, J. Nunes and D. Olive (2000) Role of Tec kinase in nuclear factor of activated T cells signaling. INTERNATIONAL IMMUNOLOGY, 12, 1547-1552
W. C. Yang, M. Ghiotto, B. Barbarat and D. Olive (1999) The role of Tec protein-tyrosine kinase in T cell signaling. Journal of Biological Chemistry, 274, 607-617
W. C. Yang and D. Olive (1999) Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway. EUROPEAN JOURNAL OF IMMUNOLOGY, 29, 1842-1849