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Research Findings

(2022) First nitrate sensor development
(2022) A novel nitrate transport activity sensor- NiTra-NPF1.3
(2021) Histone H3 lysine 4 trimethylation-regulated GRF11 expression is essential for the iron deficiency response in Arabidopsis thaliana.
(2021) Stress associated proteins coordinate the activation of comprehensive antiviral immunity in Phalaenopsis orchids.
(2022) Co-option of SHOOT MERISTEMLESS network regulates protocorm-like-body development in Phalaenopsis aphrodite
(2021) Designs, applications, and limitations of genetically encoded fluorescent sensors to explore plant biology
(2021) Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy
(2020) SUMO protease SMT7 modulates ribosomal protein L30 to regulate cell-size checkpoint function
(2020) Feedback inhibition of AMT1 NH4+-transporters mediated by CIPK15 kinase
(2020) Development of the first-in-class diabetes drug, PS1
(2020) Lost in translation of genetic information? Back to the beginning to pinpoint translation initiators
(2020) Widespread Exon Junction Complex Footprints in the RNA Degradome Mark mRNA Degradation before Steady State Translation
(2020) Understanding the regulation mechanism of root meristem development by RGF1 peptide
(2020) Specific inactivation of an antifungal bacterial siderophore by a fungal plant pathogen
(2019) SnRK1-eIFiso4G1 signaling relay regulates the translation of specific mRNAs in Arabidopsis under submergence
(2019) A Regulatory Cascade Involving Transcriptional and N-end Rule Pathways in Rice under Submergence
(2019) TRANSPORTER OF IBA1 links auxin and cytokinin to influence root architecture.
(2019) 3D Imaging of Tapetal Mitochondria Suggests the Importance of Mitochondrial Fission in Pollen Growth
(2019) Arabidopsis IRON DEFICIENCY TOLERANT1 for iron biofortification and heavy metal phytoremediation.
(2018) The role of nutrient uptake, signaling, and sensing for ammonium nutrition in plants
(2018) biosensor
(2018) Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-α-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice
(2018) Chromosome-level assembly, genetic and physical mapping of Phalaenopsis aphrodite genome provides new insights into species adaptation and resources for orchid breeding
(2018) Distinct heat shock factors and chromatin modifications mediate the organ-autonomous transcriptional memory of heat stress
(2018) O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer
(2018) Application of protoplast technology to CRISPR/Cas9 mutagenesis: from single‐cell mutation detection to mutant plant regeneration
(2018) Improvement of clonal micropropagation in Phalaenopsis orchids
(2018) R&D of a botanical drug for diabetes
(2017) Novel Biosensors for Monitoring Nitrogen Uptake at the Cellular Level for Improving Fertilizer Utilization by Plants
(2017) Application of protoplast technology to CRISPR/Cas9 mutagenesis: From single cell mutation detection to mutant plant regeneration
(2017) A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer
(2017) A Standardized Wedelia chinensis Extract Overcomes the Feedback Activation of HER2/3 Signaling upon Androgen-Ablation in Prostate Cancer
(2017) Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway
(2017) Heat-shock protein HSP101 affects the release of ribosomal protein mRNAs for recovery after heat shock
(2017) Orchidstra 2.0 - A Transcriptomics Resource for the Orchid Family
(2017) Ratiometric Matryoshka biosensors from a nested cassette of green- and orange-emitting fluorescent proteins.
(2016) Identification of plant vacuolar transporters mediating phosphate storage
(2016) Identification of a chlorophyll dephytylase involved in chlorophyll turnover in Arabidopsis
(2016) A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice
(2016) A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice
(2016) Design and Functional Analysis of Fluorescent Nitrate and Peptide Transporter Activity Sensors in Yeast Cultures
(2016)
(2016) Metastatic progression of prostate cancer is mediated by autonomous binding of galectin-4-O-glycans to cancer cells
(2015) Research and development of Bidens pilosa for coccidiosis control
(2015) Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway
(2015) Developing ex-vivo 3D mammary tumor/organoid culture system for evaluating interactive immune check point molecular and cellular activities in tumor stromal microenvironment
(2015) A salt-regulated peptide derived from the CAP superfamily protein negatively regulates Salt-stress tolerance in Arabidopsis
(2015) Glutathione plays an essential role in nitric oxide-mediated iron deficiency signaling and iron deficiency tolerance in Arabidopsis.
(2014) Root-secreted nicotianamine from Arabidopsis halleri facilitates zinc hypertolerance by regulating zinc bioavailability
(2014) Quantitative Peptidomics Study Reveals a Wound-Induced Peptide from PR-1 Regulates Immune Signaling in Tomato
(2014) Characterization of an Insecticidal Toxin and Pathogenicity of Pseudomonas taiwanensis against Insects
(2014) A Positive Feedback Loop between HSP101 and HSA32 Modulates Long-term Acquired Thermotolerance Illustrating Diverse Heat Stress Responses in Rice Varieties
(2014) Chlorophyll synthase is involved in reutilization of chlorophyllide during chlorophyll turnover
(2013) Terapeutic potential and mechanism of cytopiloyne
(2013) Interplay between Heat Shock Proteins, HSP101 and HSA32, Prolongs Heat Acclimation Memory Posttranscriptionally in Arabidopsis
(2013) Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice
(2013) Identification of Downstream Components of Ubiquitin-Conjugating Enzyme PHOSPHATE2 by Quantitative Membrane Proteomics in Arabidopsis Roots
(2013) NITROGEN LIMITATION ADAPTATION, a Target of MicroRNA827, Mediates Degradation of Plasma Membrane–Localized Phosphate Transporters to Maintain Phosphate Homeostasis in Arabidopsis
(2013) Submergence confers immunity mediated by the WRKY22 transcription factor in Arabidopsis
(2013) Degradation of the Fe uptake transporter IRT1
(2013) Arabidopsis miR399-PHO2 and miR827-NLA modules function independently but cooperatively to maintain phosphate homeostasis
(2013) Fe nutrient and circadian period length
(2012) Biological function of copper chaperones: copper homeostasis and biomass
(2012) A sensitive LC-ESI-TOF-MS method for the detection of phytosiderophores and their iron complexes in roots
(2012) Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skin via posttranslational mechanisms.
(2012) Dietary Administration of Scallion Extract Effectively Inhibits Colorectal Tumor Growth: Cellular and Molecular Mechanisms in Mice.
(2012) PHO2-Dependent Degradation of PHO1 Modulates Phosphate Homeostasis in Arabidopsis
(2012) UniQua: A Universal Signal Processor for MS-Based Qualitative and Quantitative Proteomics Applications
(2012) Tunnel Frit: A Nonmetallic In-Capillary Frit for Nanoultra High-Performance Liquid Chromatography - Mass Spectrometry Applications
(2012) A novel Formosan fungal laccase and its applications
(2011) The Role of Class A1 Heat Shock Factors (HSFA1s) in Response to Heat and Other Stresses in Arabidopsis
(2011) Recent gene duplication and subfunctionalization produced a mitochondrial GrpE, the nucleotide exchange factor of Hsp70 complex, specialized in thermotolerance to chronic heat stress in Arabidopsis
(2011) Fe homeostasis based Zn tolerance in the Zn/Cd hyperaccumulator A. halleri
(2011) SUMOylation is involved in the Cu tolerance and distribution in plants
(2011) Glutathione plays a role in the cross-homeostasis between Fe and Zn
(2011) Signaling Network in Sensing Phosphate Availability in Plants
(2011) Vacuolar Ca2+/H+ Transport Activity Is Required for Systemic Phosphate Homeostasis Involving Shoot-to-Root Signaling in Arabidopsis
(2011) Transcriptional regulation during hypoxia stress in Arabidopsis
(2011) Construction of Transcriptomic Database of Phalaenopsis and Gene Expression Profiling Studies
(2011) Interleukin-4 Enhances Trafficking and Functional Activities of GM-CSF-Stimulated Mouse Myeloid-Derived Dendritic Cells at Late Differentiation Stage
(2010) Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses.
(2010) Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling
(2010) Advanced Influenza Vaccine Technology: Mammalian Expression of Virus-like Particles Mimicking Authentic Viruses
(2010) Myeloid-derived suppressor cells prevent type 1 diabetes in murine models
(2009) Uncovering Small RNA-Mediated Responses to Phosphate Deficiency in Arabidopsis by Deep Sequencing
(2009) Method for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of dioscorea
(2009) Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumor growth and lung metastasis and doubles survival time in mice
(2009) Differential Proteomic Profiling Identifies Novel Molecular Targets of Paclitaxel and Phytoagent Deoxyelephantopin against
(2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice
(2009) Transgenic expression of human gp100 and RANTES at specific time points for suppression of melanoma
(2009) IRT3 is a Zn-regulated plasma membrane Zn and Fe transporter
(2009) Model Evaluation of the Phytoextraction Potential of Heavy Metal Hyperaccumulators and Non-hyperaccumulators
(2008) Regulatory Network of MicroRNA399 and PHO2 by Systemic Signaling
(2008) A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth in Vivo through Anti-proliferation and Pro-apoptosis
(2008) Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells
(2007) A Heat-Inducible Transcription Factor, HsfA2, Is Required for Extension of Acquired Thermotolerance in Arabidopsis
(2007) Natural galactolipids from Crassocephalum rabens suppress skin inflammation and melanoma tumor
(2006) Arabidopsis Hsa32, a novel heat-shock protein, is essential for acquired thermotolerance during long recovery after acclimation
(2006) Cytopiloyne for preventing type 1 diabetes
(2006) Regulation of phosphate homeostasis by microRNA
(2006) A design of metal binding peptides: Proteomic survey of copper-binding domains in Arabidopsis roots
(2004) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies
(2002) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies