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Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation
Food Frontiers |
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楊文欽博士團隊成功推動科研落地 創新新藥技術邁向新里程
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Novel Experimental Mouse Model to Study the Pathogenesis and Therapy of Actinobacillus pleuropneumoniae Infection
Pathogens |
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Functional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp
Scientific Reports |
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Transcriptomic Insights and the Development of Microsatellite Markers to Assess Genetic Diversity in the Broodstock Management of Litopenaeus stylirostris
Animals |
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Transcriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.)
BMC Genomics |
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
ELIFE |
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Enhancing the color and stress tolerance of cherry shrimp (Neocaridina davidi var. red) using astaxanthin and Bidens Pilosa
PLOS ONE |
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Crosstalk within Intestinal EpitheliumEnteroendocrine Cells and Paneth Cells: Key Communicators Among Intestinal Epi-thelial CellsAspects of Intestinal Absorption, Homeostasis, and Immunity, Biomedicine
BIOMEDICINE |
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經濟部國家發明創作獎
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Phytochemistry, Pharmacology and Mode of Action of the Anti-Bacterial Artemisia Plants
Bioengineering |
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Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice
Cellular and Molecular Life Sciences |
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Early Life Exposure to C16-Ceramide Improves Learning and Short-Term Memory Behavior during Adulthood in Mice
ACS Chemical Neuroscience |
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A Novel Phytogenic Formulation, EUBIO-BPSG, as a Promising One Health Approach to Replace Antibiotics and Promote Reproduction Performance in Laying Hens
Bioengineering |
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Anti-coccidial properties and mechanisms of an edible herb, Bidens pilosa, and its active compounds for coccidiosis
Scientific Reports |
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Glatiramer acetate enhances myeloid-derived suppressor cell function via recognition of paired Ig-like receptor B
JOURNAL OF IMMUNOLOGY |
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Cytotoxic property of Streptocaulon baumii extracts and their isolated compounds against different human cancer cell lines
Philippine Science Letters |
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Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway
Oncogene |
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Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis
Scientific Reports |
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Herbal remedies for coccidiosis control: A review of plants, compounds and anticoccidial actions
Evidence-Based Complementary and Alternative Medicine |
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Field trial of medicinal plant, Bidens pilosa, against eimeriosis in broilers
Scientific reports |
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Cytopiloyne, a polyacetylenic glucoside from Bidens pilosa, acts as a novel anticandidal agent via regulation of macrophages
Journal of ethnopharmacology |
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Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARgamma pathways
Scientific reports |
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Beneficial effect of Bidens pilosa on body weight gain, food conversion ratio, gut bacteria and coccidiosis in chickens
PLoS One |
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Data on the effect of Cytopiloyne against Listeria monocytogenes infection in mice
Data in Brief |
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Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes
Evidence-based Complementary and Alternative Medicine |
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Mechanistic Study of the Phytocompound, 2-β-D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches
Evidence-based Complementary and Alternative Medicine |
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Complementary and Alternative Medicine for Diabetes 2014
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
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Effect of Bidens pilosa on infection and drug resistance of Eimeria in chickens
Research in veterinary science |
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Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells
JOURNAL OF LEUKOCYTE BIOLOGY |
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Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle
Cellular Signalling |
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Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic Plant L
Evidence-Based Complementary and Alternative Medicine |
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Polarization and reprogramming of myeloid-derived suppressor cells
Journal of molecular cell biology |
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Natural cures for type 1 diabetes: A review of phytochemicals, Biological actions, and clinical potential
Current Medicinal Chemistry |
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Myeloid-Derived Suppressor Cells in Autoimmune Diabetes: Their Anti-diabetic Potential and Mechanism
Journal of Diabetes & Metabolism |
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Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling
BMC complementary and alternative medicine |
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Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds
Evidence-Based Complementary and Alternative Medicine |
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Complementary and alternative medicine for diabetes
Evidence-Based Complementary and Alternative Medicine |
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Botanical, Pharmacological, Phytochemical and Toxicological Aspects of the Anti-diabetic plant Bidens pilosa L
Evidence-based Complementary and Alternative Medicine |
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Bidens pilosa L. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology.
Evidence-Based Complementary and Alternative Medicine |
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Anti-diabetic effect and mode of action of cytopiloyne
Evidence-Based Complementary and Alternative Medicine |
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Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine
Cancer Immunology Immunotherapy |
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Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES
Journal of Biomedical Science |
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Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice
Journal of veterinary science |
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Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways
BMC complementary and alternative medicine |
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Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways
Evidence-Based Complementary and Alternative Medicine |
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Catenarin prevents type 1 diabetes in non-obese diabetic mice via inhibition of leukocyte migration involving the MEK6/p38 and MEK7/JNK pathways
Evidence-Based Complementary and Alternative Medicine |
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Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica
PloS one |
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Anti-inflammatory properties of phenolic compounds and crude extract from Phorphyra dentata
Journal of Ethnopharmacology |
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Anti-hyperglycemic properties of crude extract and triterpenes from Poria cocos
Evidence-based Complementary and Alternative Medicine |
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Suppression of cell cycle progression by Jun dimerization protein 2 (JDP2) involves down-regulation of cyclin A2
ONCOGENE |
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Myeloid-derived suppressor cells prevent type 1 diabetes in murine models
JOURNAL OF IMMUNOLOGY |
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Role of Cybr, a cytohesin binder and regulator, in CD4+ T-cell function and host immunity
MOLECULAR IMMUNOLOGY |
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Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract
Journal of Ethnopharmacology |
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Anti-diabetic properties of three common Bidens pilosa variants in Taiwan
PHYTOCHEMISTRY |
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咸豐草的功效
科學發展 |
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The effect of centaurein on interferon gamma expression and Listeria infection in mice
TOXICOLOGY AND APPLIED PHARMACOLOGY |
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Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-g expression
Journal of Ethnopharmacology |
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Cytopiloyne, a Polyacetylenic Glucoside, Prevents Type 1 Diabetes in Non-obese Diabetic Mice
JOURNAL OF IMMUNOLOGY |
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Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator
Journal of Ethnopharmacology |
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Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based study
Genomics |
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The distinct effect of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice J Biomed Sci
Journal of Biomedical Science |
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The SH3 domain of Tec kinase is essential for its targeting to activated CD28 costimulatory molecule
EUROPEAN JOURNAL OF IMMUNOLOGY |
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Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice
Planta Medica |
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Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain
JOURNAL OF IMMUNOLOGY |
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Tec kinases: a family with multiple roles in immunity
IMMUNITY |
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Role of Tec kinase in nuclear factor of activated T cells signaling
INTERNATIONAL IMMUNOLOGY |
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The role of Tec protein-tyrosine kinase in T cell signaling
Journal of Biological Chemistry |
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Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway
EUROPEAN JOURNAL OF IMMUNOLOGY |
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國家農業科學獎
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蛋白雙硫異構酶(Pdia4)負責調控胰島細胞衰竭和糖尿病
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On-Site Diagnosis of Poultry Coccidiosis by a Miniature Mass Spectrometer and Machine Learning
ACS Agricultural Science & Technology |
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農業生物科技研究中心楊文欽團隊榮獲國家農業科學獎
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Functional and Mechanistic Studies of Two Anti-coccidial Herbs, Bidens pilosa and Artemisia indica
Planta Medica |
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Protein disulfide isomerase a4 promotes lung cancer development via the Stat3 pathway in stromal cells Clinical and Translational Medicine
Clinical and Translational Medicine |
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Glutamatergic Neurons Differentiated from Embryonic Stem Cells: An Investigation of Differentiation and Associated Diseases
International Journal of Molecular Sciences |
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Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach
Frontiers in Endocrinology |
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Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling
International Journal of Molecular Sciences |
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Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy
EMBO Molecular Medicine |
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Sesamol Ameliorates Renal Injury-Mediated Atherosclerosis via Inhibition of Oxidative Stress/IKKα/p53
Antioxidants |
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Bidens pilosa: Nutritional Value and Benefits for Metabolic Syndrome
eFood |
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Authentication, phytochemical characterization and anti-bacterial activity of twoArtemisiaspecies
Food Chemistry |
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Toxicity study of Bidens pilosa in animals
Journal of Traditional and Complementary Medicine |
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Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential
Pharmacological Research |
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Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons
Journal of Agricultural and Food Chemistry |
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糖尿病市場首見藥PS1開發
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糖尿病植物藥開發
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多功能蛋白Pdia4透過抑制細胞凋亡導致腫瘤生長
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研發抗雞隻球蟲咸豐草配方
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Cytopiloyne治療糖尿病的潛力與機制
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骨髓衍生免疫抑制細胞可以預防第一型糖尿病
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預防第一型糖尿病的聚乙炔類 (CP)
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2020未來科技獎
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2019台灣創新博覽會創新發明獎
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國家新創獎
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Lecture Award of Asia-Pacific Association of Agricultural Research Institutions (APAARI)
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Outstanding Poster Award of APAARI
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2018年台灣創新技術博覽會科技部展區重點技術
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中華天然藥物學會論文獎
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中華民國雜草學會 優良壁報論文獎
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2016年美洲華人生物學科學會(SCBA)最佳壁報論文獎
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2015年美洲華人生物學科學會(SCBA)最佳壁報論文獎
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台灣生醫暨新農業產業選秀大賽新農組潛力新秀獎
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第11屆國家新創獎
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經濟部智財局國家發明創作獎
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International Inventor prize
(國際發明家學術國光獎章)
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科技部獎勵特殊優秀人才
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中研院前瞻計畫(2010 Career Development Award of Academia Sinica)
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第六屆國家新創獎
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白蘭氏第四屆(2007)健康百萬論文獎優良論文指導教授
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用於腫瘤診斷及治療之多炔糖?衍生物的標靶PDIA4
Taiwan I570411 楊文欽 |
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Pdia4, target of cytopiloyne derivatives, for tumor diagnosis and treatment
USA-regular US9382330B2 楊文欽 |
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治療糖尿病之組合物
Taiwan I522108 楊文欽 |
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Anti-coccidial prevention and treatment of Bidens pilosa and its phytochemicals
PCT, USA-regular US 9072312B2 楊文欽,張力天 |
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咸豐草與其化合物預防與治療球蟲感染 Anti-coccidial prevention and treatment of Bidens pilosa and its phytochemicals
Taiwan TW I 465242 楊文欽,張力天 |
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抑制白血球之CXC趨化素受器4型之虎丈萃取物及其製造方法
Taiwan TWI 422383 楊文欽,楊緒信,林雅俐,ClementMettling |
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Polyacetylenic compounds
EP EP2384758 B1 楊文欽,張力天 |
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polyacetylenic compounds for protecting against pancreatic islet atrophy polyacetylenic compounds for protecting against pancreatic islet atrophy
USA-regular US8575116 B1 楊文欽 |
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用於防止胰島萎縮症之聚炔類化合物
Taiwan TWI 412508 楊文欽 |
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POLYACETYLENIC COMPOUNDS FOR PROTECTING AGAINST PANCREATIC ISLET ATROPHY
USA-regular US 8536141 楊文欽 |
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免疫調節之組合物
Taiwan TW I 377347 楊文欽,張書林,江一民,徐麗芬 |
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利用centaurein預防或治瘵胞內菌感染
Taiwan TW I 373341 楊文欽 |
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聚炔類化合物
Taiwan TWI 370738 楊文欽 |
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免疫調節之組合物
Taiwan TW I 369497 楊文欽,張書林,江一民,徐麗芬 |
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POLYACETYLENIC COMPOUNDS FOR STIMULATING INSULIN GENE EXRESSION, PRODUCTION AND SECRETION
USA-regular US 8147880 B2 楊文欽 |
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BUTANOL EXTRACT OF BIDENS PILOSA
USA-regular US 8048860 徐麗芬,江一民,張書林,張力天,楊文欽 |
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Polyacetylenic compounds
EP EP1955701 楊文欽 |
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咸豐草之正丁醇萃取物
Taiwan TW I 347191 楊文欽,張書林,徐麗芬,江一民,張力天 |
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Polyacetylenic compounds
USA-regular US7763285B2 楊文欽 |
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Immunomodulatory Compositions
USA-regular 7691575 楊文欽,張書林,江一民,徐麗芬 |
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Antibacterial Treatment and Composition
USA-regular 7341752 楊文欽 |
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繼發現胰島素百年後的新突破? 蛋白雙硫異構酶(Pdia4)負責調控胰島細胞衰竭和糖尿病
EMBO Molecular Medicine, e11668 |
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