昭和草之癌症化學預防活性科學驗證與分子作用機制研究
昭和草為台灣民間宣稱可適用於炎症的可食用植物。我們利用巨噬細胞、癌細胞、基因活性為基礎之體外生物活性測定方法，以及老鼠皮膚發炎與黑色素瘤動物模式，發現昭和草植物抽出物之活性半乳糖脂質化學成分：1,2-di-O-alpha-linolenoyl-3-O-beta-galactopyranosyl-sn-glycerol（簡稱為dLGG）。dLGG顯著降低體內和體外過度生成的NO與LPS或TPA刺激下NOS和COX-2之基因和蛋白質表現以及PGE2之生成。本研究並證明富含抗發炎dLGG成分之昭和草抽出物可較癌症化療藥劑-順鉑(cisplatin)更顯著抑制黑色素瘤於C57BL/6J小鼠內之生長。結構-活性相關性之研究中證明dLGG之雙亞麻醯基甘油結構部份為重要的活性結構特徵。此研究為首次科學驗證昭和草之抗發炎活性，並首度發現其所含半乳糖脂質化合物成分具抑制皮膚 黑色素腫瘤之生長。同研究人員:侯珈禎、陳奕平、吳志鴻、黃啟彰、王升陽、楊寧蓀、徐麗芬*
徐麗芬
特聘研究員
(02) 2787-2102
jaclyn@gate.sinica.edu.tw
辦公室：農科大樓 A731
實驗室
位置: 農科大樓 A728
電話: (02) 2787-2100
- 07/2018- to date Distinguished Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 05/2019-08/2019 Visiting Scholar of UC Davis, USA
- 03/2008- 8/2016 Vice Director, Agricultural Biotechnology Research Center, Academia Sinica
- 2008-2018 Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 2008-2014 Coordinator of Molecular and Biological Agricultural Sciences program of
Taiwan International Graduate Program (TIGP-MBAS), Academia Sinica - 2003-2008 Associate Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 1998-2003 Assistant Research Fellow, Institute of BioAgricultural Sciences, Academia Sinica
- 1994-1997 Postdoctoral Research Fellow, Department of Biochemistry and Biophysics, Iowa State University, USA
- 1991-1992 Postdoctoral Research Fellow, Department of Agricultural Chemistry, National Taiwan University
- 1990-1991 Postdoctoral Research Fellow, Department of Biochemistry, Chang Gung University
SPECIAL ACHIEVEMENT
- Received US FDA approval for Zhaohe Cao (昭和草)-based botanical drug for an Investigational New Drug (IND) for cancer therapy (2017).