Natural galactolipids from Crassocephalum rabens suppress skin inflammation and melanoma tumor
Crassocephalum rabens (Asteraceae) is a popular anti-inflammatory folk medicine and food supplement. This is the first study to provide scientific evidences for the anti-inflammatory and cancer chemopreventive functions of C. rabens extract and its major constituent compound (dLGG). Results obtained from in vitro and in vivo cell- and gene-based bioassays indicate that dLGG is a potent NO scavenger which can inhibit both iNOS and COX-2 activities at transcriptional and translational levels in murine macrophages as well as in mouse skin. A dLGG-enriched extract markedly suppressed B16 melanoma growth in C57BL/6J mice. This study demonstrates the detailed molecular mechanisms underlying the novel anti-inflammatory and tumor-suppressive effects of a natural galactolipid.同研究人員:Chia-Chung Hou, Yi-Ping Chen, Jyh-Horng Wu, Chi-Chang Huang, Sheng-Yang Wang, Ning-Sun Yang, and Lie-Fen Shyur*
Lie-Fen Shyur
Distinguished Research Fellow
(02) 2787-2102
jaclyn@gate.sinica.edu.tw
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- 07/2018- to date Distinguished Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 05/2019-08/2019 Visiting Scholar of UC Davis, USA
- 03/2008- 8/2016 Vice Director, Agricultural Biotechnology Research Center, Academia Sinica
- 2008-2018 Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 2008-2014 Coordinator of Molecular and Biological Agricultural Sciences program of Taiwan International Graduate Program (TIGP-MBAS), Academia Sinica
- 2003-2008 Associate Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 1998-2003 Assistant Research Fellow, Institute of BioAgricultural Sciences, Academia Sinica
- 1994-1997 Postdoctoral Research Fellow, Department of Biochemistry and Biophysics, Iowa State University, USA
- 1991-1992 Postdoctoral Research Fellow, Department of Agricultural Chemistry, National Taiwan University
- 1990-1991 Postdoctoral Research Fellow, Department of Biochemistry, Chang Gung University
SPECIAL ACHIEVEMENT
- Received US FDA approval for Zhaohe Cao (???)-based botanical drug for an Investigational New Drug (IND) for cancer therapy (2017).