論文著作
| Chang, C.-T., Chen, Y.-H., and Shyur, L.-F.* (2024) Phytocompounds from essential oil of Mentha aquatica Lime Mint prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRASQ61L keratinocyte and reprogramming macrophage activities. Phytomedicine, 122, 155161 |
| Lin, H.-H., Wu, Y.-S., Chang, M.-T., Shyur, L.-F., and Lin, Y.-L.* (2024) Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvant. Vaccine, 42, 782-794 |
| Pan, Y.-C., Chu, P.-Y., Lin, C.-C., Hsieh, C.-Y., Hsu, W.-Y., Shyur, L.-F., Yang, J.-C., Chang, W.-C., and Wu, Y.-C.* (2024) Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer. Molecular Oncology, 18,1866-1884 |
| Lien, Y.-Y.#, Shyur, L.-F.#, Cheng, Y.-B., Chang, M.-T., Chang, C.-T., Chen, Y.-H., Lai, G.-H., Liao, H.-Y., and Cheng, M.-C.* (2024) Trifolium pratense as a novel phytogenic supplement, is an anticoccidial agent in chickens. Poultry Science, 103, 104064 |
| Tsao, C.-H., Hsieh, W.-C., Lin, F.-J., Yang, R.-Y., Chang, M.-T., Apaya, M. K., Shyur, L.-F., Ke, L.-Y., Zouboulis, C. C., and Liu, F.-T.* (2023) The critical role of galectin-12 in modulating lipid metabolism in sebaceous glands. Journal of Investigative Dermatology, 143, 913-924 |
| Valdez, G., Shyur, L.-F., Wang, S.-Y.*, and Chen, S.-E.* (2023) Phytogenics in ginger, Origanum vulgare, and Syzygium aromaticum and their potential as a feed additive against Clostridium perfringens in broiler production. Animals, 13, 3643 |
| Ho, Y.-F. Ho, Shiau, J.-Y., Sri Malek, A. M., Shyur, L.-F.*, and Saiful, A. K.* (2023) Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549. Applied Biochemistry and Biotechnology, DOI:10.1007/s12010-023-04384-2 |
| Cheng, Y.-T., Nakagawa-Goto, K., Lee, K.-H., and Shyur, L.-F.* (2023) miRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones. Antioxidants & Redox Signaling, 38, 198-214 |
| Lin, H.-H, Wu, Y.-S., Jian, T-Y., Laio, J.-Y., Chang, M.-T., Shyur, L.-F.*, and Lin, Y.-L.* (2023) Phytogalactolipids activate humoral immunity against colorectal cancer. Journal of Experimental & Clinical Cancer Research, 42, 95 |
| Wei, W.-C., Shyur, L.-F., and Yang, N.-S.* (2022) Cellular and molecular signaling as targets for cancer vaccine therapeutics.. cells, 111,590 |
| Chiang, K.-M., Chen, J.-F., Yang, C.-A., Xiu, L., Yang, H.-C., Shyur, L.-F., and Wen-Harn Pan (2022) Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study. metabolites, 12, 495 |
| Chang, M.-T., Tsai, L.-C., Nakagawa-Goto, K., Lee, K.-H., and Shyur, L.-F.* (2022) Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib resistant melanoma via GPX4 inhibition and metabolic reprogramming. Pharmacological Research, 178, 106148 |
| Yang, C.-C., Chang, M.-M., Chang, C.-K., and Shyur, L.-F.* (2021) Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment. Cancers, 13(16), 4120 |
| Wu, T.-N., Chen, H.-M., and Shyur, L.-F.* (2021) Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment. International Journal of Molecular Sciences, 22, 13571 |
| Cvetanova, B., Li, M.-Y., Yang, C.-C., Hsiao, P.-W., Yang, Y.-C., Feng, J.-H., Shen, Y.-C., Nakagawa-Goto, K., Lee, K.-H., and Shyur, L.-F.* (2021) Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice. International Journal of Molecular Sciences, 22(6), 3226 |
| Shyur, L.-F.#, Varga V.#, Chen, C.-M., Mu, S.-C., Chang, Y.-C., and Li, S.-C.* (2021) Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes. BOTANICAL STUDIES, 62,, 7 |
| Shih, C.-K., Chen, C.-M., Varga, V., Shih, L.-C., Chen, P.-R., Lo, S.-F., Shyur, L.-F., and Li, S.-C. (2020) White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice. Food & Nutrition Research, 64, 3609 |
| Chen, P.-Y., Hsieh, M.-J., Tsai, Y.-T., Chung, H.-H., Shyur, L.-F., Hsieh, C.-H., and Kin-Ying To* (2020) Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa. Plants, 9, 1483 |
| Chung, H.-H., Ting, H.-M., Wang., W.-H., Chao, Y.-T., Hsieh, C.-H., Apaya, M. K., Sung, Y.-C., Lin, S.-S., Hwu, F.-Y., and Shyur, L.-F.* (2020) Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches. Journal of Experimental Botany, doi:10.1093/jxb/eraa457, 10 |
| Apaya, M. K., Hsiao, P.-W., Yang, Y.-C., and Shyur, L.-F.* (2020) Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer. Cancers, 12, 199 |
| Huang C.-C., Chang, M.-T., Leu, H.-B., Yin, W.-H., Tseng, W.-K., Wu, Y.-W., Lin, T.-H., Yeh, H.-I, Chang, K.-C., Wang, J.-H., Wu, C.-C., Shyur, L.-F.*, and Chen, J.-W.* (2020) Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease. SCIENTIFIC REPORTS, 10, 8105 |
| Cvetanova, B., Shen, Y.-C., and Shyur, L.-F.* (2019) Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death. Frontiers in Pharmacology, 10 |
| Wen-Wan Chao, Ya-Wen Cheng, Yet-Ran Chen, Shu-Hua Lee, Ching-Yi Chiou, Lie-Fen Shyur (2019) Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity. Phytomedicine, 56, 194–206 |
| Chang, C.-T., Soo, W.-N., Chen, Y.-H., and Shyur, L.-F.* (2019) Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib.. Molecules, 24, 2344 |
| Apaya Maria Karmella, Shiau Jeng-Yuan, Liao Guo-Shiou, Liang Yu-Jen, Chen Chia-Wei, Yang Hsin-Chou, Chu Chi-Hong, Yu Jyh-Cherng, Shyur Lie-Fen (2019) Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer. Journal of Experimental & Clinical Cancer Research, 38(1), 187 |
| Yang, C.-C., Chang, C.-K., Chang, M.-T. , and Shyur, L.-F.* (2018) Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice. International Journal of Cancer, 143, 3248–3261 |
| Hsu, S.-F., Lee, Y.-B., Lee, Y.-C., Chung, A.-L., Apaya, K. M., Shyur, L.-F., Cheng, C.-F., Ho, F.-M., and Meng, T.-C. (2018) Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1. The FEBS Journal, 285(9), 1593-1610 |
| Hua, M. D., Senthil Kumar, R., Shyur, L.-F., Cheng, Y.-B., Tian, Z., Oelmüller, R. and Yeh, K.-W. (2017) Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction. Scientific Reports, 7, 9291 |
| Shang, K.-M., Su, T.-H., Lee, W. L., Hsiao, W.-W., Chiou, C.-Y., Ho, B.-Y., Wang, S.-Y., and Shyur, L.-F.* (2017) Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer. Phytomedicine, 24, 39-48 |
| Shiau, J.-Y., Nakagawa-Goto, K., Kuo-Hsiung Lee, K.-H., Shyur, L.-F.* (2017) Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death. Oncotarget, 8(34), 56942-56958 |
| Shiau, J.-Y., Chang, Y.-Q., Nakagawa-Goto, K., Kuo-Hsiung Lee, K.-H., Shyur, L.-F.* (2017) Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions. Frontiers in Pharmacology, 8, 398 |
| Maria Karmella Apaya, Meng-Ting Chang, Lie-Fen Shyur* (2016) Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics. Pharmacology and Therapeutics, 162, 58-68 |
| Nakagawa-Goto, K., Chen, J.-Y., Cheng, Y.-T., Lee, W.-L., Takeya, M., Saito, Y., Lee, K.-H., and Shyur, L.-F.* (2016) Novel sesquiterpene lactone analogues as potent anti-breast cancer agents . Molecular Oncology, 10(6), 921-937 |
| Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, and Lie-Fen Shyur* (2016) A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice. MOLECULAR CANCER THERAPEUTICS, 15(6), 1163-1176 |
| Cheng, Y.-T., Yang, C.-C., and Shyur, L.-F.* (2016) Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy . Pharmacological Research, 114, 128-143 |
| Lee, H.-M., Patela, V., Shyur, L.-F., and Lee, W. L. (2016) Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells. Phytomedicine, 23(12), 1535-1544 |
| Liu, W.-C., Maestre-Reyna, M., Jeng, W.-Y., Lee, C.-C., Hsu, C.-A., Wen, T.-N., Wang, A. H.-J.*, and Shyur, L.-F.* (2015) Structural and functional roles of glycosylation in fungal laccase from Lentinus sp . PLoS ONE, 10(4), UNSP e0120601 |
| Apaya, M. K., Lin, C.-Y., Chiou, C.-Y., Yang, C.-C., Ting, C.-Y., and Shyur, L.-F.* (2015) Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway. Molecular Medicine, 21, 988-1001 |
| Deng, Y.-T., Lin-Shiau, S.-Y. Shyur, L.-F., and Lin, J.-K.* (2015) Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice. Food & Function, 6(5), 1539-1546 |
| Cheng, Y.-B., Lo, I-W., Shyur, L.-F., Yang, C.-C., Hsu, Y.-Mi., Su, J.-H., Lu, M.-C., Chiou, S.-F., Lan, C.-C., Wu, Y.-C., Chang, F.-R. (2015) New alkaloids from Formosan zoanthid Zoanthus kuroshio. Tetrahedron, 71, 8601-8606 |
| Shiau, J.-Y., Yin, S.-Y., Chang, S.-L., Hsu, Y.-J., Chen, K.-W., Kuo, T.-F., Feng, C.-S., Yang, N.-S., Shyur, L.-F.*, Yang, W.-C.*, and Wen, T.-N.* (2015) Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches. Evidence-based Complementary and Alternative Medicine, 475610 |
| Wei, W.-C., Liu, C.-P., Yang, W.-C., Shyur, L.-F., Sheu, J.-H., Chen, S.-S., and Yang, N.-S. (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells. Journal of Leukocyte Biology, 97(6), 1071-1080 |
| Lee, W.-L., Huang, J.-Y., and Shyur, L.-F.* (2013) Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxidative Medicine and Cellular Longevity, 2013, 925804 |
| Liao, G.-S., Apaya, M. K., and Shyur, L.-F.* (2013) Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy. Evidence-based Complementary and Alternative Medicine, 2013, 437948 |
| Huang, C.-C., Lin, K.-J., Cheng, Y.-W., Hsu, C.-A., Yang, S.-S., and Shyur, L.-F.* (2013) Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis. Journal of Nutritional Biochemistry, 24(3), 516-530 |
| Chou#, T.-W., Feng#, J.-H., Huang, C.-C., Cheng, Y.-W., Chien, S.-C., Wang, S.-Y.*, and Shyur, L.-F.* (2013) A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice. PLoS ONE, 8(10), e77626 |
| Lee, W.-L., Shiau, J.-Y., and Shyur, L.-F.* (2012) Taxol, camptothecin and beyond for cancer therapy . Advances in Botanical Research, 62, 133-178 |
| Ho, B.-Y., Lin, C.-H., Apaya, M. K., Chao, W.-W., and Shyur, L.-F.* (2012) Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice. Journal of Traditional and Complementary Medicine, 2(4), 301-311 |
| Hung, S.-W., Chiu, C.-F., Chen, T.-A., Chu, C.-L., Huang, C.-C., Shyur, L.-F., Liang, C.-M., and Liang, S.-M (2012) Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer. Breast Cancer Research and Treatment, 136, 89-105 |
| Liu, W.-C., Lin, Y.-S., Jeng, W.-Y., Chen, J.-H., Wang, A. H.-J., and Shyur, L.-F.* (2012) Engineering of dual functional hybrid glucanases. Protein Engineering Design & Selection, 25(11), 771-780 |
| Lee, W.-L. and Shyur, L.-F.* (2012) Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation . Free Radical Biology & Medicine, 52, 1423-1436 |
| Chen, S.-C., Wu, P.-H., Su, Y.-C., Wen, T.-N., Wei, Y.-S., Wang, N.-C., Hsu, N.-C., Wang, Andrew H.-J., and Shyur, L.-F.* (2012) Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1. Protein Engineering Design & Selection, 25(11), 761-769 |
| Hsu, C.-A., Wen, T.-N., Su, Y.-C., Jiang, Z.-B., Chen, C.-W., and Shyur, L.-F.* (2012) Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp . Environmental Science and Technology, 46, 5109-5117 |
| Wen, C.-C.#, Shyur, L.-F.#, Jan, J.-T.#, Liang, P.-H., Kuo, C.-J., Arulselvan, P., Wu, J.-B., Kuo, S.-C., and Yang, N.-S. (2011) Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. Journal of Traditional and Complementary Medicine, 1, 41-50 |
| Tsai, L.-C., Hsiao, C.-H., Liu, W.-Y., Yin, L.-M., and Shyur, L.-F. (2011) Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors. Biochemical and Biophysical Research Communication, 407, 593-598 |
| Su, P.-F., Li, C.-J., Hsu, C.-C., Benson, S., Wang, S.-Y., Chan, S. I., Wu, S.-H., Huang, W.-C., Shyur, L.-F.*, and Yang, N.-S.* (2011) Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo. Evidence-based Complementary and Alternative Medicine, 44572 |
| Jeng, W.-Y., Wang, N.-C., Lin, C.-T., Shyur, L.-F., and Wang, H.-J. A. (2011) Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection. Journal of Biological Chemistry, 286, 45030-45040 |
| Shyur, L.-F.*, Huang, C.-C., Hsu, Y.-Y., Cheng, Y.-W., Yang, S.-D. (2011) A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression. Phytochemistry, 72(4-5), 391-399 |
| Hou, C.-C., Huang, C.-C., and Shyur, L.-F.* (2011) Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression. Journal of Agricultural and Food Chemistry, 59, 11966-11974 |
| Shyur, L.-F.*, Yang, N.-S., Kang, P.-L., Sun, S.-J., Wang, S.-Y. (2010) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment. Malaysia patent, issued No. PI20032638 |
| Shyur, L.-F.*, Lee, S.-H., Chang, S.-T., Lo, C.-P., Kuo, Y.-H., and Wang, S.-Y. (2010) Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways. Phytomedicine, 18, 16-24 |
| Chen, J.-H., Tsai, L.-C., Huang, H.-C., and Shyur, L.-F.* (2010) Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase. PROTEINS: Structure, Function, and Bioinformatics, 78, 2820-2830 |
| Huang, C.-C., Lo, C.-P., Chiu, C.-Y., and Shyur, L.-F.* (2010) Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice. British Journal of Pharmacology, 159, 856-871 |
| Hsan, K. M., Chen, C.-C., and Shyur, L.-F.* (2010) Current research and development of chemotherapeutic agents for melanoma. Cancers, 2, 397-419 |
| Wai-Leng Lee, Tuan-Nan Wen, Jeng-Yuan Shiau, and Lie-Fen Shyur (2010) Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells. Journal of Proteome Research, 9(1), 237-253. |
| Hou, C.-C., Chen, C.-H., Yang, N.-S., Lo, C.-P., Wang, S.-Y., Tien, Y.-J., Tsai, P.-W. and Shyur, L.-F.* (2010) Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants. Journal of Nutritional Biochemistry, 21(11), 1045-59 |
| Shyur, L.-F.*, Yang, N.-S., Kang, P.-L., Sun, S.-J., Wang, S.-Y. (2009) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment. PRC patent issued No. CN ZL03158682. 1, 中國專利 |
| Shyur, L.-F.*, Yang, N.-S., Kang, P.-L., Sun, S.-J., Wang, S.-Y. (2009) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment. Australia patent issued No. AU 2003244587, 澳洲專利 |
| Shyur, L.-F.*, Chen, J.-L., and Yang, N.-S. (2009) Truncated glucanase with enhanced activity and method for making the same. (US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies), No. 7037696 and No. 201683 |
| Shyur, L.-F.*, Wen, T.-N., Lee, S.-H., and Yang, N.-S. (2009) Truncated 1,3-1,4-beta- D-glucanase. US patent issued No. 7,527,958, No. 7,527,958 |
| Lin, Y.-S., Tsai, L.-C., Lee, S.-H., Yuan, H. S., and Shyur, L.-F.* (2009) Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1790(4), 231-239 |
| Shyur, L.-F.*, Hou, C.-C., Wu, J.-H., Chen, Y.-P., Wang, S.-Y., Huang, C.-C., and Yang, N.-S. (2009) Cancer and inflammatory disorder treatment. S patent issued No. 7547455 and ROC patents pending, No. 7547455 |
| Yang, W.-C., Chang, S.-L., Chang, L.-T., Chiang, Y.-M., and Shyur, L.-F. (2008) Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation. (US and ROC patents pending) (One technology licensing/transfer to local biotech company), |
| Yang, W.-C., Chang, S.-L., Chiang, Y.-M., and Shyur, L.-F. (2008) Immunomodulatory phytocompounds and the highly efficient platform to screen the same. US patent pending, |
| Tsai, L.-C.*, Huang, H.-C., Hsiao, C.-H., Chiang, Y.-N., Shyur, L.-F.*, Lin, Y.-S., and Lee, S,-H. (2008) Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, D64, 1259–1266 |
| Yang, N.-S., Su, P.-F., Li, C.-J., and Shyur, L.-F. (2008) Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea. (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company), No, 7,419,690 B2 |
| Shyur, L.-F.* and Yang, N.-S.* (2008) Metabolomics for phytomedicine research and drug development . CURRENT OPINION IN CHEMICAL BIOLOGY, 12, 66-71 |
| Shyur, L.-F.*, Huang, C.-C., Lo, C.-P., Chiu, C.-Y., Chen, Y.-P., Wang, S.-Y., and Chang, S.-T. (2008) Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators. PHYTOCHEMISTRY, 69, 1348-1358 |
| Wang, C.-Y., Staniforth, V., Chiao, M.-T., Hou, C.-C., Wu, H.-M., Yeh, K.-C., Chen, C.-H., Hwang, P.-I., Wen, T.-N., Shyur, L.-F.* (2008) Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells. BMC Genomics, 9, 479-498 |
| Wu, J.-H., Tung, Y.-T., Chien, S.-C., Wang, S.-Y., Kuo, Y.-H., Shyur, L.-F.*, and Chang, S.-T.* (2008) Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production. Journal of Agricultural and Food Chemistry, 56, 1567-1573 |
| Lin, F.-M., Tsai, C.-H., Yang, Y.-C., Tu, W.-C., Chen, L.-R., Liang, Y.-S., Wang, S.-Y., Shyur, L.-F., Chien, S.-C., Cha, T.-L., Hsiao, P.-W. (2008) A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis. Cancer Research, 68, 6634-6642 |
| Su, P.-F., Staniforth, V., Li, Ch.-J., Wang, C.-Y., Chiao, M.-T., Wang, S.-Y., Shyur, L.-F., and Yang, N.-S. (2008) Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues. Journal of Biomedical Science, 15(6), 813-22 |
| Tsai, L.-C.*, Chen, Y.-N. and Shyur, L.-F. (2008) Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition . Journal of Computer-Aided Molecular Design, 22(12), 915-923 |
| C.-C. Wen, Y.-H. Kuo, J.-T. Jan, P.-H. Liang, S.-Y. Wang, H.-G. Liu, C.-K. Lee, S.-T. Chang, C.-J. Kuo, S.-S. Lee, C.-C. Hou, P.-W. Hsiao, S.-C. Chien, L.-F.* Shyur and N.-S.* Yang (2007) Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus. Journal of Medicinal Chemistry, 50, 4087-4095 |
| Wen, C.-C., Kuo, Y.-H., Jan, J.-T., Liang, P.-H., Wang, S.-Y., Liu, H.-G., Lee, C.-K., Chang, S.-T., Kuo, C.-J., Lee, S.-S., Hou, C.-C., Hsiao, P.-W., Chien, S.-C., Shyur, L.-F. and Yang, N.-S. (2007) Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus. Journal of Medicinal Chemistry, 50(17), 4087-4095 |
| Chang, S.-L., Chiang, Y.-M., Chang, C.-L., Yeh, H.-H., Shyur, L.-F., Kuo, Y.-H., Wu, T.-K., and Yang, W.-C.* (2007) Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. Journal of Ethnopharmacology, 112, 232-236 |
| Hsieh, Y.-H., Kuo, P.-M., Chien, S.-C., Shyur, L.-F., and Wang, S.-Y. (2007) Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide. Phytomedicine, 14, 675-680 |
| Chiang, Y.-M., Cicero L.-T., Chang, S.-L., Yang, W.-C.*, and Shyur, L.-F.* (2007) Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. Journal of Ethnopharmacology, 110, 532-538 |
| Hou, C.-C., Chen, Y.-P., Wu, J.-H., Huang, C.-C., Wang, S.-Y., Yang, N.-S., and Shyur, L.-F.* (2007) A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma . Cancer Research, 67, 6907-6915 |
| Wu, L.-W., Chiang, Y.-M., Chuang, H.-C., Lo, C.-P., Yang, K.-Y., Wang, S.-Y., and Shyur, L.-F.* (2007) A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7. Planta Medica, 73, 655-661. |
| Shyur, L.-F.*, Yang, N.-S., Kang, P.-L., Sun, S.-J., Wang, S.-Y. (2006) Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies. (US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company), 7033617 |
| Wang, C.-Y., Chiao, M.-T., Yen, P.-J., Huang, W.-C., Hou, C.-J., Chung, S.-C., Yeh, K.-C., Shyur, L.-F.*, and Yang, N.-S.* (2006) Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study. Genomics, 88(6), 801-808 |
| C. L. Chang, H. K. Kuo, S. L. Chang, Y. M. Chiang, T. H. Lee, W. M. Wu, L. F. Shyur and W. C. Yang (2005) The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice. Journal of Biomedical Science, 12, 79-89 |
| Chang, C. L.-T., Kuo, H.-K., Chiang, Y.-M., Chang, S.-L., Shyur, L.-F. and Yang, W.-C.* (2005) The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice. Journal of Biomedical Science, 12, 79-89 |
| Chang, C. L.-T., Kuo, H.-K., Chiang, Y.-M., Chang, S.-L., Shyur, L.-F. and Yang, W.-C.* (2005) The distinct effects of a butanol fraction of Bidens pilosa extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice. Journal of Biomedical Science, 12, 79-89 |
| J. H. Wu, Y. T. Tung, S. Y. Wang, L. F. Shyur, Y. H. Kuo and S. T. Chang (2005) Phenolic antioxidants from the heatwood of Acacia confusa. Journal of Agricultural and Food Chemistry, 53, 5917-5921 |
| Wu, J.-H., Tung, Y.-T., Wang, S.-Y., Shyur, L.-F., Kuo, Y.-H. and Chang, S.-T. (2005) Phenolic Antioxidants From the Heartwood of Acacia confusa. Journal of Agricultural and Food Chemistry, 53, 5917-5921 |
| Y. M. Chiang, C. P. Lo, Y. P. Chen, S. Y. Wang, N. S. Yang, Y. H. Kuo and L. F. Shyur (2005) Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. British Journal of Pharmacology, 146, 352-363 |
| Chiang, Y.-M., Lo, C.-P., Chen, Y.-P., Wang, S.-Y., Yang, N.-S., Kuo, Y.-H. and Shyur, L.-F.* (2005) Ethyl caffeate suppress NF B activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro or in mouse skin. British Journal of Pharmacology, 146, 352-363 |
| L. C. Tsai, L. F. Shyur, Y. S. Cheng S. H. Lee (2005) Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose. J Mol Biol, 354, 642-651 |
| Tsai, L.-C., Shyur, L.-F., Cheng, Y.-S. and Lee, S.-H.. (2005) Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-1-D-glucanase in complex with -1,3-1,4-cellotriose. J. Mol. Biol., 354, 642-651 |
| Wang, S.-Y., Wu, C.-L., Chu, F.-H., Shyur, L.-F.* and Chang, S.-T.* (2005) Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity. Holzforschung, 59, 295-299 |
| S. Y. Wang, C. L. Wu, F. H. Chu, S. C. Chien, Y. H. Kuo, L. F. Shyur and S. T. Chang (2005) Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity. Holzforschung, 59, 295-299 |
| Wen, T.-N., Chen, J.-L., Lee, S.-H., Yang, N.-S. and Shyur, L.-F..* (2005) A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance. Biochemistry, 44, 9197-9205 |
| T. N. Wen, J. L. Chen, S. H. Lee, N. S. Yang and L. F. Shyur (2005) A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance. Biochemistry, 44, 9197-9205 |
| Wen, T.-N., Chen, J.-L., Lee, S.-H., Yang, N.-S. and Shyur, L.-F..* (2005) A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance. Biochemistry, 44, 9197-9205 |
| Staniforth, V., Wang, S.-Y., Shyur, L.-F. and Yang, N.-S.* (2004) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. Journal of Biological Chemistry, 279(7), 5877-5885 |
| Staniforth, V., Wang, S.-Y., Shyur, L.-F. and Yang, N.-S.* (2004) Shikonin, hytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor. Journal of Biological Chemistry, 279, 5877-5885 |
| S. L. Chang, C.L.T. Chang, Y. M. Chiang, R. H. Hsieh, C. R. Tzeng, T. K. Wu, H. K. Sytwu, N. S. Yang, L. F. Shyur and W. C. Yang (2004) Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice. Planta Medica, 70, 1045-1051 |
| Chang, S.-L., Chang, C. L.-T., Chiang, Y.-M., Hsieh, R.-H., Tzeng, C.-R., Wu, T.-K., Sytwu, H.-K., Shyur L.-F.* and Yang, W.-C.* (2004) Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice. Planta Medica, 70, 1045-1051 |
| Chang, S.-L., Chang, C. L.-T., Chiang, Y.-M., Hsieh, R.-H., Tzeng, C.-R., Wu, T.-K., Sytwu, H.-K., Shyur L.-F.* and Yang, W.-C.* (2004) Polyacetylenic compound and butanol fraction from Bidens pilosa Linn can modulate the differentiation of helper T cells and prevent autoimmune diabetes in nonobese diabetes mice. Planta Medica, 70, 1045-1051 |
| Wu, L.-W.*, Chiang, Y.-M., Chuang, H.-C., Wang, S.-Y., Yang, G.-W., Chen, Y.-H., Lai, L.-Y. and Shyur, L.-F.* (2004) Polyacetylenes function as anti-angiogenic agents. PHARMACOLOGICAL RESEARCH, 21, 2112-2119 |
| Wu, L.-W.*, Chiang, Y.-M., Chuang, H.-C., Wang, S.-Y., Yang, G.-W., Chen, Y.-H., Lai, L.-Y. and Shyur, L.-F.* (2004) Polyacetylenes function as anti-angiogenic agents. Pharmaceutical Research, 21, 2112-2119 |
| Shyur, L.-F., Chiang, Y.-M., Chuang, D.-Y., Wang, S.-Y., Kuo, Y.-H., Tsai, P.-W. and Shyur, L.-F.* (2004) Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa. Journal of Ethnopharmacology, 95, 409-419 |
| Y. M. Chiang, D. Y. Chuang, S. Y. Wang, Y. H. Kuo, P. W. Tsai and L. F. Shyur (2004) Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa. Journal of Ethnopharmacology, 95, 409-419 |
| N. S. Yang, L. F. Shyur, C. H. Chen, S. Y. Wang and C. M. Tzeng (2004) Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells. Journal of Biomedical Science, 11, 418-422 |
| Shyur, L.-F.*, Chen, C.-H., Lo, C.-P., Wang, S.-Y., Kung, P.-L., Sun, S.-J., Chang, C. Allen, Tzeng, C.-M. and Yang, N.-S. (2004) Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus. Journal of Biomedical Science, 11, 928-939 |
| Shyur, L.-F.*, Chen, C.-H., Lo, C.-P., Wang, S.-Y., Kung, P.-L., Sun, S.-J., Chang, C. Allen, Tzeng, C.-M. and Yang, N.-S. (2004) Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus. J. Biomed. Sci., 11, 928-939 |
| Wang, S.-Y., Wu, J.-H., Cheng, S.-S., Lo, C.-P., Chang, H.-N., Shyur, L.-F.* and Chang, S.-T.* (2004) Antioxidant activity of extracts from Calocedrus formosana leaf, bark and heartwood. Journal of Wood Science, 50, 422-426 |
| S. Y. Wang, J. H. Wu, S. S. Cheng, C. P. Lo, H. N. Chang, N. S. Yang, L. F. Shyur and S. T. Chang (2004) Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood. JOURNAL OF WOOD SCIENCE, 50, 422-426 |
| Wang, J.-H., Lin, K.-F., Benson, S. A., Sun, S.-J., Cheng, W.-M., Wang, S.-Y., Shyur, L.-F. and Yang, N.-S.* (2003) Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing. J. Genet. Mol. Biol., 14, 133-144 |
| J. H. Wang, K. F. Lin, S. A. Benson, S. J. Sun, W. M. Cheng, S. Y. Wang, L. F. Shyur and N. S. Yang (2003) Tissue array transgene expression system for the evaluation of effect of medicinal herbs on wound-healing. J Genet Mol Biol, 14, 133-144 |
| V. Staniforth, S. Y. Wang, L. F. Shyur and N. S. Yang (2003) Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. Journal of Biological Chemistry, 279, 5877-5885 |
| L. C. Tsai, L. F. Shyur, S. H. Lee, S. S. Lin and S. H.Yuan (2003) Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes. JOURNAL OF MOLECULAR BIOLOGY, 330, 607-620 |
| S. Y. Wang, H. N. Chang, K. T. Lin, C. P. Lo, N. S. Yang and L. F. Shyur (2003) Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica. Journal of Agricultural and Food Chemistry, 51, 1506-1512 |
| S. Y. Wang, Y. H. Kuo, H. N. Chang, H. S. Tsay, K. F. Lin, N. S. Yang and L. F. Shyur (2002) Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata. Journal of Agricultural and Food Chemistry, 50, 1859-1865 |
| H. L. Cheng, L. C. Tsai, S. S. Lin, H. S. Yuan, N. S. Yang, S. H. Lee and L. F. Shyur (2002) Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme. Biochemistry, 41, 8759-8766 |
| J. L. Chen, L. J. Tsai, T. N. Wen, J. B. Tang, S. H. Yuan and L. F. Shyur (2001) Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability. Journal of Biological Chemistry, 276, 17895-17901 |
| L. C. Tsai, L. F. Shyur, S. S. Lin and H. S. Yuan (2001) Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 57, 1303-1306 |
| S. T. Chang, J. H. Wu, S. Y. Wang, P. L. Kang, N. S. Yang and L. F. Shyur (2001) Antioxidant activity of extracts from Acacia confusa bark and heartwood. Journal of Agricultural and Food Chemistry, 49, 3420-3424 |
| S. Y. Wang, J. H. Wu, L. F. Shyur, Y. H. Kuo and S. T. Chang (2001) Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata. Holzforschung, 56, 487-492 |
徐麗芬
特聘研究員
(02) 2787-2102
jaclyn@gate.sinica.edu.tw
辦公室：農科大樓 A731
實驗室
位置: 農科大樓 A728
電話: (02) 2787-2100
- 07/2018- to date Distinguished Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 05/2019-08/2019 Visiting Scholar of UC Davis, USA
- 03/2008- 8/2016 Vice Director, Agricultural Biotechnology Research Center, Academia Sinica
- 2008-2018 Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 2008-2014 Coordinator of Molecular and Biological Agricultural Sciences program of
Taiwan International Graduate Program (TIGP-MBAS), Academia Sinica - 2003-2008 Associate Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
- 1998-2003 Assistant Research Fellow, Institute of BioAgricultural Sciences, Academia Sinica
- 1994-1997 Postdoctoral Research Fellow, Department of Biochemistry and Biophysics, Iowa State University, USA
- 1991-1992 Postdoctoral Research Fellow, Department of Agricultural Chemistry, National Taiwan University
- 1990-1991 Postdoctoral Research Fellow, Department of Biochemistry, Chang Gung University
SPECIAL ACHIEVEMENT
- Received US FDA approval for Zhaohe Cao (昭和草)-based botanical drug for an Investigational New Drug (IND) for cancer therapy (2017).