2025
Integrating genomics and targeted metabolite profiling to elucidate disease-suppression mechanisms of Bacillus velezensis GFB08.. Current research in microbial sciences
, 9, 100503
Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen Beauveria bassiana.. Frontiers in microbiology
, 16, 1583637
Terpenoids with Antiangiogenic Activity from Formosan Soft Coral Caementabunda hypotentaculata.. Marine biotechnology (New York, N.Y.)
, 27(2), 71
Pseudopeptides of Marine Vibrio spp. from Taiwan and Their Combined Treatment Effects with Commercial Antibiotics.. Planta medica
, 91(6-07), 371-381
2024
Structure-Functional Activity of Pyrone Derivatives for Inhibition of Barnacle Settlement and Biofilm Formation.. Marine biotechnology (New York, N.Y.)
, 26(5), 1000-1008
Dimethyl sulfoxide, an alternative for control of Nosema ceranae infection in honey bees (Apis mellifera).. Archives of insect biochemistry and physiology
, 116(4), e22099
Transgene-free CRISPR/Cas9-mediated gene editing through protoplast-to-plant regeneration enhances active compounds in Salvia miltiorrhiza.. Plant biotechnology journal
, 22(6), 1549-1551
Functional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp.. Scientific reports
, 14(1), 11584
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies.. Natural product reports
2023
In situ spatiotemporal mapping of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitor in pineapple (Ananas comosus) fruit tissue by MALDI mass spectrometry imaging. Frontiers in Natural Products
, 2, 1160541
Chemo‐ and Regioselective Construction of Functionalized Isocoumarin, Flavone, and Isoquinolinedione <i>via</i> a One‐pot Reaction of <i>o</i> ‐Quinol Acetate and Soft Nucleophiles. ADVANCED SYNTHESIS & CATALYSIS
Metabolomic Analysis Demonstrates the Impacts of Polyketide Synthases PKS14 and PKS15 on the Production of Beauvericins, Bassianolide, Enniatin A, and Ferricrocin in Entomopathogen Beauveria bassiana.. Metabolites
, 13(3), 425
A Novel Phytogenic Formulation, EUBIO-BPSG, as a Promising One Health Approach to Replace Antibiotics and Promote Reproduction Performance in Laying Hens.. Bioengineering (Basel, Switzerland)
, 10(3), 346
2022
Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference.. Journal of Food and Drug Analysis
, 30(3), 440-453
Exploring the relationship between metabolite composition and the cold/hot properties ascribed in traditional Chinese medicine by mass spectral molecular networking–a pilot study. Journal of Food and Drug Analysis
, 30(3), 402-416
Microbial polyketides and their roles in insect virulence: from genomics to biological functions.. Natural product reports
, 39(11), 2008-2029
Surface-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (SALDI-IMS)-Based Detection of Vinca Alkaloids Distribution in the Petal of Madagascar Periwinkle.. Methods in molecular biology (Clifton, N.J.)
, 2505, 45-58
Surfactin secreted by Bacillus amyloliquefaciens Ba01 is required to combat Streptomyces scabies causing potato common scab.. Frontiers in plant science
, 13, 998707
Transcriptome of Nosema ceranae and Upregulated Microsporidia Genes during Its Infection of Western Honey Bee (Apis mellifera).. Insects
, 13(8), 716
Untargeted LC-MS/MS-Based Multi-Informative Molecular Networking for Targeting the Antiproliferative Ingredients in Tetradium ruticarpum Fruit.. MOLECULES
, 27(14), 4462
Rhizospheric plant-microbe synergistic interactions achieve efficient arsenic phytoextraction by Pteris vittata.. Journal of hazardous materials
, 434, 128870
Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.. Communications biology
, 5(1), 454
Evaluation of the Antifungal Activities of Photorhabdus akhurstii and Its Secondary Metabolites against Phytopathogenic Colletotrichum gloeosporioides.. Journal of fungi (Basel, Switzerland)
, 8(4), 403
2021
The potential biocontrol agent Paenibacillus polymyxa TP3 produces fusaricidin-type compounds involved in the antagonism against gray mold pathogen Botrytis cinerea. Phytopathology
The brown root rot fungus Phellinus noxius affects microbial communities in different root-associated niches of Ficus trees. Environmental microbiology
Visualizing Vinca Alkaloids in the Petal of Catharanthus roseus Using Functionalized Titanium Oxide Nanowire Substrate for Surface-assisted Laser Desorption/ionization Imaging Mass Spectrometry. Plant J
, 105, 1123-1133
Targeted Isolation of Xenicane Diterpenoids from Taiwanese Soft Coral Asterospicularia laurae. Marine Drugs
, 19(3), 123
Specific Inactivation of an Anti-fungal Bacterial Siderophore by a Fungal Plant Pathogen. ISME J.
, 15, 1858-1861
Polyketides with Anti-neuroinflammatory Activity from Theissenia cinerea. Journal of Natural Products
, 84(7), 1898-1903
Natural polyketide 6-pentyl-2H-pyrone-2-one and its synthetic analogues efficiently prevent marine biofouling. Biofouling
, 37(3), 257-266
Natural alkaloid tryptanthrin exhibits novel anticryptococcal activity. Medical Mycology
, 59(6), 545-556
Integrated Omics Strategy Reveals Cyclic Lipopeptides Empedopeptins from Massilia sp YMA4 and Their Biosynthetic Pathway. Marine Drugs
, 19(4), 209
2020
Whole Genome Sequencing and Tn5-Insertion Mutagenesis of Pseudomonas taiwanensis CMS to Probe Its Antagonistic Activity Against Rice Bacterial Blight Disease. International Journal of Molecular Sciences
, 21(22), 8639
2019
Efficient identification of fungal antimicrobial principles by tandem MS and NMR database. Journal of food and drug analysis
, 27(4), 860-868
2018
Genome mining of Streptomyces xinghaiensis NRRL B-24674(T) for the discovery of the gene cluster involved in anticomplement activities and detection of novel xiamycin analogs. Applied microbiology and biotechnology
, 102(22), 9549-9562
Exploration of Fungal Metabolic Interactions Using Imaging Mass Spectrometry on Nanostructured Silicon. Journal of Natural Products
, 81(7), 1527-1533
Biological control of potato common scab by Bacillus amyloliquefaciens Ba01. PloS one
, 13(4), e0196520
Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa. Marine Drugs
, 16(2), E47
A piezo-ring-on-chip microfluidic device for simple and low-cost mass spectrometry interfacing. The Analyst
, 143(4), 981-988
A polysaccharide derived from Trichosporon sp. culture strongly primes plant resistance to viruses. Molecular plant-microbe interactions : MPMI
, 31(12), 1257-1270
2017
Imaging mass spectrometry for metabolites: technical progress, multimodal imaging, and biological interactions. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
, 9(5), e1387
Bacillus Classification Based on Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry-Effects of Culture Conditions. Scientific reports
, 7(1), 15546
Butyrolactones and Diketopiperazines from Marine Microbes: Inhibition Effects on Dengue Virus Type 2 Replication. Planta Medica
, 83(01/02),158-163
2016
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature biotechnology
, 34(8), 828-837
Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry: environment stability and activation by simple vacuum oven desiccation. The Analyst
, 141(16), 4973-4981
Involvement of type VI secretion system in secretion of iron chelator pyoverdine in Pseudomonas taiwanensis. Scientific reports
, 6, 32950
Clarification of the Antagonistic Effect of the Lipopeptides Produced by Bacillus amyloliquefaciens BPD1 against Pyricularia oryzae via In Situ MALDI-TOF IMS Analysis. Molecules
, 21(12), 1670
2015
Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach.. Scientific reports
, 5, 12856
Rapid identification of haloarchaea and methanoarchaea using the matrix assisted laser desorption/ionization time-of-flight mass spectrometry. Scientific reports
, 5, 16326
New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression. Organic letters
, 17(10), 2330-2333
Avenaciolides: potential MurA-targeted inhibitors against peptidoglycan biosynthesis in methicillin-resistant Staphylococcus aureus (MRSA). Journal of the American Chemical Society
, 137(1), 267-275
2014
Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS chemical biology
, 9(10), 2300-2308
Characterization of the flocculating agent from the spontaneously flocculating microalga Chlorella vulgaris JSC-7. Journal of bioscience and bioengineering
, 118(1), 29-33
Bringing microbial interactions to light using imaging mass spectrometry. Natural product reports
, 31(6), 739-755
Analysis of the biosynthesis of antibacterial cyclic dipeptides in Nocardiopsis alba. Archives of microbiology
, 196(11), 765-774
2013
Polyenylpyrrole Derivatives Inhibit NLRP3 Inflammasome Activation and Inflammatory Mediator Expression by Reducing Reactive Oxygen Species Production and Mitogen-Activated Protein Kinase Activation. PloS one
, 8(10), e76754
Generation of Reactive Oxygen Species by Polyenylpyrroles Derivatives Causes DNA Damage Leading to G2/M Arrest and Apoptosis in Human Oral Squamous Cell Carcinoma Cells. PLoS One
, 8(6), e67603
Characterization of flocculating agent from the self-flocculating microalga Scenedesmus obliquus AS-6-1 for efficient biomass harvest. Bioresource Technology
, 145, 285-289
2012
Oligosaccharide and peptidoglycan of Ganoderma lucidum activate the immune response in human mononuclear cells. Journal of Agricultural and Food Chemistry
, 60(11), 2830-2837
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. Journal of proteomics
, 75, 5069-5076
Asperjinone, a Nor-Neolignan, and Terrein, a Suppressor of ABCG2-Expressing Breast Cancer Cells, from Thermophilic Aspergillus terreus. Journal of Natural Products
, 75(4), 630-635
2011
Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4. The Journal of biological chemistry
, 286(24), 21041-21051
Structure and function of glycolipids in thermophilic bacteria. Advances in Experimental Medicine and Biology
, 705, 367-380
Sequencing cyclic peptides by multistage mass spectrometry. Proteomics
, 11(18), 3642-3650
A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2. The Journal of biological chemistry
, 286(20), 17736-17745
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nature chemical biology
, 7(11), 794-802
2010
Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis. Journal of Medicinal Chemistry
, 53(22), 7967-7978
Structural variation of glycolipids from Meiothermus taiwanensis ATCC BAA-400 under different growth temperatures. Organic & biomolecular chemistry
, 8(19), 4252-4254
Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proceedings of the National Academy of Sciences of the United States of America
, 107(37), 16286-16290
Acetogenin and prenylated flavonoids from Helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by neutrophils. Planta Medica
, 76(5), 447-453
2009
Translating metabolic exchange with imaging mass spectrometry. Nature chemical biology
, 5(12), 885-887
Marinopyrrole A target elucidation by acyl dye transfer. Journal of the American Chemical Society
, 131(34), 12094-12096
Imaging mass spectrometry of natural products. Natural product reports
, 26(12), 1521-1534
Discovery of new natural products by intact-cell mass spectrometry and LC-SPE-NMR: malbranpyrroles, novel polyketides from thermophilic fungus Malbranchea sulfurea. Chemistry-A European Journal
, 15(43), 11573-11580
Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica. Journal of Natural Products
, 72(7), 1273-1278
2008
TLR-independent induction of human monocyte IL-1 by phosphoglycolipids from thermophilic bacteria. Glycoconjugate Journal
, 25(5), 427-439
Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways. Journal of Agricultural and Food Chemistry
, 56(21), 9892-9898
New cyclic peptides from the seeds of Annona squamosa L and their anti-inflammatory activities. Journal of Agricultural and Food Chemistry
, 56(2), 386-392
Mono-tetrahydrofuran annonaceous acetogenins from Annona squamosa as cytotoxic agents and calcium ion chelators. Journal of Natural Products
, 71(5), 764-771
Cyclopeptides with anti-inflammatory activity from seeds of Annona montana. Journal of Natural Products
, 71(8), 1365-1370
2007
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. Bioorganic & medicinal chemistry
, 15(10), 3450-3456
Synthesis of a tetrasaccharide glycosyl glycerol Precursor to glycolipids of Meiothermus taiwanensis ATCC BAA-400. The Journal of organic chemistry
, 72(14), 5427-5430
Cytotoxic withanolides from Tubocapsicum anomalum. Journal of Natural Products
, 70(5), 747-753
Cytotoxic sesquiterpene lactones from Pseudoelephantopus spicatus. Journal of Natural Products
, 70(11), 1761-1765
Cytotoxic polyketides containing tetramic acid moieties isolated from the fungus Myceliophthora Thermophila: elucidation of the relationship between cytotoxicity and stereoconfiguration. CHEMISTRY-A EUROPEAN JOURNAL
, 13(24), 6985-6991
2006
Structural elucidation of phosphoglycolipids from strains of the bacterial thermophiles Thermus and Meiothermus. Journal of lipid research
, 47(8), 1823-1832
New sesquiterpene lactones from the aerial parts of Pseudoelephantopus spicatus. Chemical & pharmaceutical bulletin
, 54(11), 1599-1601
New constituents from stems of Goniothalamus amuyon. Chemical & pharmaceutical bulletin
, 54(7), 1040-1043
Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var pendula. Planta Medica
, 72(14), 1344-1347
2005
Squadinorside, A Novel 7,9′-Dinorlignan Skeleton from the Stems of Annona squamosa. HELVETICA CHIMICA ACTA
, 88(10), 2731-2737
An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions. Planta Medica
, 71(10), 904-909
2004
Two Sesquiterpene-coumarins from the Roots of Ferula marmarica. HETEROCYCLES
, 63(9), 2101-2109
Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils. Planta Medica
, 70(3), 256-258
Annosqualine, a Novel Skeleton Alkaloid from the Stems of Annona squamosa. HELVETICA CHIMICA ACTA
, 87(6), 1392-1399
2003
Total Synthesis of 3,4-Dihydrobenzo[h]quinazolin-4-one and Structural Elucidation of Perlolidine and Samoquasine A. TETRAHEDRON LETTERS
, 44(2), 319-322
Secoiridoid glycoside and alkaloid constituents of Hydrangea chinensis. Journal of Natural Products
, 66(9), 1245-1248
Cytotoxic styrylpyrones from Goniothalamus amuyon. Journal of Natural Products
, 66(4), 487-490
Chemical and Pharmacological Studies of ent-Kaurane Diterpenoids from Annonaceae. Chinese Pharmaceutical Journal
, 55(4), 287-304
A Natural Pyrone Derivative from the Woods of Polyalthia Longifolia var Pendula. Chinese Pharmaceutical Journal
, 55(4), 279-285
2002
New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa. Journal of Natural Products
, 65(10), 1462-1467