Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice
Melanoma is a highly metastatic disease with an increasing rate of incidence worldwide. It is treatment refractory and has poor clinical prognosis; therefore, development of new therapeutic agents for metastatic melanoma are urgently requir...
A Standardized Wedelia chinensis Extract Overcomes the Feedback Activation of HER2/3 Signaling upon Androgen-Ablation in Prostate Cancer
Androgen receptor (AR)-mediated signaling play an essential role in prostate cancer for survival, growth, and invasion. Crosstalk between the AR and other signaling pathways in prostate cancer (PCa) severely affects the therapeutic outcome ...
A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer
Docetaxel remains the standard treatment for castration-resistant prostate cancer by improving overall survival but having severe adverse toxicity. Inflammatory cytokines in the tumor microenvironment promote docetaxel resistance through ac...
A virus-like particle vaccination strategy expands its tolerance to H3N2 antigenic drift by enhancing neutralizing antibodies against hemagglutinin stalk
Seasonal influenza viruses impact public health annually due to their continual evolution. However, the current inactivated seasonal vaccines provide poor protection against antigenically drifted viruses and require periodical reformulation...
Metastatic progression of prostate cancer is mediated by autonomous binding of galectin-4-O-glycans to cancer cells
Metastatic prostate cancer (PCa) continues to pose a difficult therapeutic challenge. PCa progression is associated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of such events are uncertain. Here...
Mammalian Expression of Virus-like Particles for Advanced Mimicry of Authentic Influenza Virus
Influenza A viruses are major human and animal pathogens with huge economic and societal impact from illness, hospitalizations, and deaths. Virus-like particles (VLPs) of influenza virus have been suggested as a vaccine candidate offering i...
Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice
Herbal remedies are the most accepted complementary and alternative medicines used among patients with prostate cancer. Plant extracts contain various compounds that have been shown to inhibit many different process of inflammation. It is i...
A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth in Vivo through Anti-proliferation and Pro-apoptosis
Prostate caner (PCa) is one of the most commonly occurring cancers in men and is also one of the top 10 fatal cancers in Taiwan. The growth of PCa cells is stimulated by androgen. Although the majority of prostate cancers initially respond ...
An optimized procedure greatly improves EST vector contamination removal. BMC
Vector contamination remains a serious concern to the data quality in the public sequence database nowadays. Based on the results presented here, we feel that our modified procedure with SeqClean should be recommended to all researchers for...
Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells
Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anti-cancer therapeutic opportunity. Here, we report four anti-proliferativ...