Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice
Melanoma is a highly metastatic disease with an increasing rate of incidence worldwide. It is treatment refractory and has poor clinical prognosis; therefore, development of new therapeutic agents for metastatic melanoma are urgently requir...
Mammalian Expression of Virus-like Particles for Advanced Mimicry of Authentic Influenza Virus
Influenza A viruses are major human and animal pathogens with huge economic and societal impact from illness, hospitalizations, and deaths. Virus-like particles (VLPs) of influenza virus have been suggested as a vaccine candidate offering i...
Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice
Herbal remedies are the most accepted complementary and alternative medicines used among patients with prostate cancer. Plant extracts contain various compounds that have been shown to inhibit many different process of inflammation. It is i...
A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth in Vivo through Anti-proliferation and Pro-apoptosis
Prostate caner (PCa) is one of the most commonly occurring cancers in men and is also one of the top 10 fatal cancers in Taiwan. The growth of PCa cells is stimulated by androgen. Although the majority of prostate cancers initially respond ...
Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells
Chronic inflammation can augment tumor development in various types of cancers, including prostate cancer (PCa). Reduction of inflammation is therefore an important anti-cancer therapeutic opportunity. Here, we report four anti-proliferativ...