miRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones.
Triple negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat and lacks targeted therapies. Emerging evidence suggests that modulating redox homeostasis through targeting mitochondrial functions may be a useful...
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming
Acquired resistance to vemurafenib (PLX4032) is a thorny issue in BRAFV600E mutant melanoma therapy. Ferroptotic programmed cell death is a potential strategy for combating therapy-resistant cancers. This study uncovers the adaptation and a...
Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice
Melanoma is a highly metastatic disease with an increasing rate of incidence worldwide. It is treatment refractory and has poor clinical prognosis; therefore, development of new therapeutic agents for metastatic melanoma are urgently requir...
Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumor growth and lung metastasis and doubles survival time in mice
Elephantopus scaber L. (Asteraceae) is a traditional herbal medicine known for its anti-cancer effect. We addressed the in vitro and in vivo bioefficacy of an abundant sesquiterpene lactone deoxyelephantopin (DET) isolated from E. scaber ag...
Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells
A major germacranolide sesquiterpene lactone, deoxyelephantopin, identified from Elephantopus scaber L. (known as 'Didancao' in Chinese medicine) showed significant anti-tumor growth and anti-metastatic effect on murine mammary adenocarcino...
Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production.
Acacia confusa Merr. (Leguminosae), a species indigenous to Taiwan, is widely distributed on the hills and lowlands of Taiwan. It represents a traditionally important commodity used for charcoal-making and construction materials, as well as...
