論文著作
| Chiung-Wen Hu, Yuan-Jhe Chang, Wei-Hung Chang, Marcus S. Cooke, Yet-Ran Chen*, and Mu-Rong Chao* (2024) A Novel Adductomics Workflow Incorporating FeatureHunter Software: Rapid Detection of Nucleic Acid Modifications for Studying the Exposome. Environ. Sci. Technol./ES&T, 58(1), 75-79 |
| C. W. Hu, Y. J. Chang, W. H. Chang, M. S. Cooke, (Y. R, Chen)*, M. R. Chao* (2023) A Novel Adductomics Workflow Incorporating FeatureHunter Software: Rapid Detection of Nucleic Acid Modifications for Studying the Exposome. ENVIRONMENTAL SCIENCE & TECHNOLOGY, Article ASAP, acs.est.3c04674 |
| Y. L. Chen, F. W. Lin, K. T. Cheng, C. H. Chang, S. C. Hung, T. Efferth, (Y. R. Chen)* (2023) XCP1 cleaves Pathogenesis-related protein 1 into CAPE9 for systemic immunity in Arabidopsis. NATURE COMMUNICATIONS, 14, 4697 |
| MS Cooke, Y. J. Chang, Y. R. Chen, C. W. Hu, M. R. Chao* (2023) Nucleic acid adductomics – The next generation of adductomics towardsassessing environmental health risks. SCIENCE OF THE TOTAL ENVIRONMENT, 856, 159192 |
| K. T. Fan, C. W. Hsu and Y. R. Chen* (2022) Mass spectrometry in the discovery of peptides involved in intercellular communication: From targeted to untargeted peptidomics approaches. MASS SPECTROMETRY REVIEWS, 2022, e21789 |
| K. T. Fan, Y. Hsu, C. F. Yeh, C. H. Chang, W. H. Chang and Y. R. Chen* (2021) Quantitative Proteomics Reveals the Dynamic Regulation of the Tomato Proteome in Response to Phytophthora infestans. International Journal of Molecular Sciences, 22(8), 4174 |
| M. T. Yang, W. H. Chang, T. F. Kuo, M. Y. Shen, C. W. Tien, Y. J. Yang, B. Y. Lai, Y. R. Chen, Y. C. Chang, W. C. Yang* (2021) Identification of Novel Biomarkers for Pre-diabetic Diagnosis Using a Combinational Approach. FRONTIERS IN ENDOCRINOLOGY, 12, E641336 |
| J. Y. Mao, Unnikrishnan, B. Unnikrishnan, H. W. Chu, S. G. Harroun, Y. R. Chen, A. T. Wu, H. T. Chang, H. J. Lin, C. C. Huang* (2021) Thermally driven formation of polyphenolic carbonized nanogels with high anticoagulant activity from polysaccharides. BIOMATERIALS SCIENCE, 9(13), 4679-4690 |
| Y. J. Chang, M. S. Cooke, Y. R. Chen, S. F. Yang, P. S. Li, C. W. Hu*, M. R. Chao* (2021) Is high resolution a strict requirement for mass spectrometry-based cellular DNA adductomics?. CHEMOSPHERE, 274, E129991 |
| Y. C. Y. Yu, T. Z. K. Hui, T. H. Kao, H. F. Liao, C. Y. Yang, C. C. Hou, H. T. Hsieh, J. Y. Chang, Y. T. Tsai, M. Pinskaya, K. C. Yang, Y. R. Chen, A. Morillon, M. H. Tsai, S. P. Lin* (2020) Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast. Frontiers In Cell And Developmental Biology, 8, E103 |
| Y. J. Chen, T. I Roumeliotis, Y. H. Chang, C. T. Chen, C. L. Han*, M. H. Lin, H. W. Chen, G. C. Chang, Y. L. Chang, C. T. Wu, M. W. Lin, M. S. Hsieh, Y. T. Wang, Y. R. Chen, I. Jonassen, F. Z. Ghavidel, Z. S. Lin, K. T. Lin, C. W. Chen, P. Y. Sheu, C. T. Hung, K. C. Huang, H. C. Yang, P. Y. Lin, T. C. Yen, Y. W. Lin, J. H. Wang, L. Raghav, C. Y. Lin, Y. S. Chen, P. S. Wu, C. T. Lai, S. H. Weng, K. Y. Su, W. H. Chang, Tsai, P. Y. Tsai, A. I. Robles, H. Rodriguez, Y. J. Hsiao, W. H. Chang, T. Y. Sung*, J. S. Chen*, S. L. Yu*, J. S. Choudhary*, H. Y. Chen*, P. C. Yang*, Y. J. Chen* (2020) Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression. Cell, 182(1), 226-244.e17 |
| Y. C. Lin, C. Y. Wu, C. H. Hu, T. W. Pai, Y. R. Chen, W. D. Wang* (2020) Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos. Antioxidants, 9(8), E731 |
| W. W. Chao, Y. W. Cheng, (Y. R. Chen), S. H. Lee, C. Y. Chiou, L. F. Shyur* (2019) Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity. PHYTOMEDICINE, 56, 194 |
| K. T. Fan, K. H. Wang, W. H. Chang, J. C, Yang, C. F. Yeh, K. T. Cheng, S. C. Hung, Y. R. Chen* (2019) Application of data-independent acquisition approach to study the proteome change from early to later phases of tomato pathogenesis responses. International Journal of Molecular Sciences, 20(4). E863 |
| Y. L. Chen, W. H. Chang, C. Y. Lee, Y. R. Chen* (2019) An Improved Scoring Method for the Identification of Endogenous Peptides based on Mascot MS/MS Ion Search. Analyst, 144(9), 3045-3055 |
| Y. L. Chen, K. T. Fan, S. C. Hung and Y. R. Chen* (2019) The role of peptides cleaved from protein precursors in eliciting plant stress reactions. New Phytologist, doi: 10.1111/nph.16241 |
| T. W. Pai*, K. H. Li, C. H. Yang, C. H. Hu, H. J. Lin, W. D. Wang, (Y. R. Chen) (2018) Multiple model species selection for transcriptomics analysis of non-model organisms. BMC BIOINFORMATICS, 19, 184 |
| K. S. Hung, C. C. Hsiao, T. W. Pai*, C. H. Hu, W. S. Tzou, W. D. Wang and Y. R. Chen (2018) Functional enrichment analysis based on long noncoding RNA associations. BMC SYSTEMS BIOLOGY, 12(Suppl 4), 45 |
| Y. R Shen, H. Y. Wang, Y. C. Kuo, S. C. Shih, C. H. Hsu, Y. R. Chen, S. R. Wu, C. Y. Wang , P. L. Kuo* (2017) SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. PLOS Genetics, 13(3), e1006631 |
| W. C. Yang, T. F. Kuo, T. Y. Chen, S. T. Jiang, K. W. Chen, Y. M. Chiang, Y. J. Hsu, Y. J. Liu, H. M. Chen, K. Yokoyama, K. C. Tsai, H. H. Yeh, Y. R. Chen, M. T. Yang, and C. Y. Yang (2017) Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway. ONCOGENE, 36(39), 5484-5496 |
| I. W. Chou, Y. H. Cheng, Y. R. Chen, P. C. H. Hsieh*, K. King (2017) Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1. Scientific reports, 7(1), 12265 |
| J. Y. Mao, H. W. LI, S. C. Wei, S. G. Harroun, M. Y. Lee, H. Y. Lin, C. Y. Chung, C. H. Hsu, Y. R. Chen, H. J. Lin*, C. C. Huang (2017) DNA Modulates the Interaction of Genetically Engineered DNA-Binding Proteins and Gold Nanoparticles: Diagnosis of High-Risk HPV Infection. ACS applied materials & interfaces, 9(51), 44307-44315 |
| M. D. Pham, T. C. Wen, H. C. Li, P. H. Hsieh, Y. R. Chen, H. C. Chang* and C. C. Han* (2016) Streamlined Membrane Proteome Preparation for Shotgun Proteomics Analysis with Triton X-100 Cloud Point Extraction and Nanodiamond Solid Phase Extraction. Materials, 9(5), 385-401 |
| M. Tsednee, Y. C. Huang, Y. R. Chen and K. C. Yeh* (2016) Identification of Metal Species by ESI-MS/MS Through Release of Free Metals from The Corresponding Metal-Ligand Complexes. Scientific Reports, 6, 26785 |
| H. M. Jan, Y. C. Chen, Y. Y. Shih, Y. C. Huang, Z. Tu, A. B. Ingel, S. W. Liu, M. S. Wu, J. Gervay-Huage, K. T. Mong, Y. R. Chen, C. H. Lin* (2016) Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence. CHEMICAL SCIENCE, 7(9), 6208-6216 |
| Shu-Yi Yin, Thomas Efferth, Feng-Yin Jian, Yung-Hsiang Chen, Chia-I Liu, Andrew H.J. Wang, Yet-Ran Chen, Pei-Wen Hsiao, Ning-Sun Yang (2016) Immunogenicity of Mammary Tumor Cells Can be Induced by Shikonin Via Direct Binding-Interference with Hnrnpa1. Oncotarget, 7(28), 43629-43653 |
| J. Y. Hsu, J. F. Hsu, Y. R. Chen, C. L. Shih, Y. S. Hsu, Y. J. Chen, S. H. Tsai, P. C. Liao* (2016) Urinary exposure marker discovery for toxicants using ultra-high pressure liquid chromatography coupled with Orbitrap high resolution mass spectrometry and three untargeted metabolomics approaches. ANALYTICA CHIMICA ACTA, 939, 73-83 |
| W. C. Wei, S. Y. Lin, C. W. Lan, Y. C. Hang, C. Y. Lin, P. W. Hsaio, Y. R. Chen, W. C. Yang, N. S. Yang* (2016) Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis. SCIENTIFIC REPORTS, 6, 36663 |
| K. S. Lynn, M. L. Cheng, T. Y. Sung, Y. R. Chen, C. Hsu, A. Chen, T. M. Lih, H. Y. Chang, C. J. Huang, M. S. Shiao, W. H. Pan*, and W. L. Hsu (2015) Metabolite identification for mass spectrometry-based metabolomics using multiple types of correlated ion information. ANALYTICAL CHEMISTRY, 87(4), 2143-2151 |
| Y. C. Kuo, Y. R. Shen, H. I. Chen, Y. H. Lin, Y. Y. Wang, Y. R. Chen, C. Y. Wang, and P. L. Kuo* (2015) SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. JOURNAL OF CELL SCIENCE, 128(5), 923-34 |
| C. H. Tsai, S. F. Tzeng, S. C. Hsieh, C. Y Lin, C .J. Tsai, Y. R. Chen, Y. C. Yang, Y. W. Chou, M. T. Lee, P. W. Hsiao* (2015) Development of a standardized and effect-optimized herbal extract of Wedelia chinensis for prostate cancer. Phytomedicine, 22(3), 406-14 |
| P. C. Lin, W. C. Hu, S. C. Lee, Y. L. Chen, C. Y. Lee, Y. R. Chen, L. Y. Liu, P. Y. Chen, S. S. Lin* and Y. C. Chang (2015) Application of an Integrated Omics Approach for Identifying Host Proteins That Interact With Odontoglossum ringspot virus Capsid Protein. MOLECULAR PLANT-MICROBE INTERACTIONS, 28(6), 711-726 |
| P. S. Chien, H. G. Nam and Y. R. Chen* (2015) A salt-regulated peptide derived from the CAP superfamily protein negatively regulates salt-stress tolerance in Arabidopsis. Journal of Experimental Botany, 66(17), 5301-5313 |
| J. Koubek, Y. R. Chen, R. P. Cheng and J. J. T. Huang* (2015) Nonorthogonal tRNA(Amber)(cys) for protein and nascent chain labeling. RNA, 21(9), 1672-82 |
| H. J. Chen, Y. C. Shen, Y. J Shiao, K. T. Liou, W. H. Hsu, P. H. Hsieh, C. Y. Lee, Y. R. Chen* and Y. L. Lin (2015) Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice. PLoS One, 10(10), e0140823 |
| C. H. Chen, T. H. Hu, T. C. Huang, Y. L. Chen, Y. R. Chen, C. C. Cheng*, and C. T. Chen (2015) Delineation of G-Quadruplex Alkylation Sites Mediated by 3,6-Bis(1-methyl-4-vinylpyridinium iodide)carbazole-Aniline Mustard Conjugates. CHEMISTRY-A EUROPEAN JOURNAL, 21(48), 17379-17390 |
| J. Catinot, J. B. Huang, P. Y. Huang, M. Y. Tseng, Y. L. Chen, S. Y. Gu, W. S. Lo, L. C. Wang, Y. R. Chen, L. Zimmerli* (2015) ETHYLENE RESPONSE FACTOR 96 positively regulates Arabidopsis resistance to necrotrophic pathogens by direct binding to GCC elements of jasmonate - and ethylene-responsive defence genes. Plant Cell & Environment, 38(12), 2721-2734 |
| L. T. Huang*, C. C. Wu, L. F. Lai, M. M. Gromiha, C. S.Wang, Y. R. Chen (2014) Data mining application in biomedical informatics for probing into protein stability upon double mutation. Applied Mathematics & Information Sciences, 8(1L), 125-132 |
| S. L. Lee, C. W. Li, K. W. Koh, H. Y. Chuang. Y. R. Chen, C. S. Lin and M. T. Chan* (2014) MSRB7 Reverses Oxidation of GSTF2/3 to Confer Tolerance of Arabidopsis Thaliana to Oxidative Stress. Journal of Experimental Botany, 65(17), 5049-5062 |
| H. M. Hsu, Y. Lee, P. H. Hsu, H. W. Liu, C. H. Chu, Y. W. Chou, Y. R. Chen, S. H. Chen and J. H. Tai* (2014) Signal transduction triggered by iron to induce the nuclear importation of a Myb3 transcription factor in the parasitic protozoan Trichomonas vaginalis. Journal of Biological Chemistry, 289(42), 29334-29349 |
| Y. L. Chen, C. Y. Lee, K. T. Cheng, W. H. Chang, R. N. Huang, H. G. Nam and Y. R. Chen* (2014) Quantitative Peptidomics Study Reveals a Wound-Induced Peptide from PR-1 Regulates Immune Signaling in Tomato. Plant Cell, 26(10), 4135-4148 |
| W. H. Chang, C. Y. Lee, C. Y. Lin; M. C. Chen, W. S. Tzou and Y. R. Chen* (2013) UniQua: a universal signal processor for MS-based qualitative and quantitative proteomics applications. Analytical chemistry, 85(2), 890-897 |
| B. Wiench, Y. R. Chen, M. Paulsen, R. Hamm, S. Schroder, N.S. Yang, and T. Efferth* (2013) Integration of Different "-omics" Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells. Evidence-Based Complementary and Alternative Medicine, 2013, 818709 |
| Lin HY, Shih CY, Liu HC, Chang J, Chen YL, Chen YR, Lin HT, Chang YY, Hsu CH, Lin HJ* (2013) Identification and characterization of an extracellular alkaline phosphatase in the marine diatom Phaeodactylum tricornutum. Marine biotechnology, 15(4), 425-436 |
| Y. C. Chang, Y. H. Yu, J. Y. Shew, W. J. Lee, J. J. Hwang, Y. H. Chen, Y. R. Chen, P. C. Wei, L. M. Chuang, W. H. Lee* (2013) Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human. EMBO Molecular Medicine, 5(8), 1165-1179 |
| J. Koubek, K. F. Lin, Y. R. Chen, R. P. Cheng*, J. J. Huang (2013) Strong anion-exchange fast performance liquid chromatography as a versatile tool for preparation and purification of RNA produced by in vitro transcription. RNA-A PUBLICATION OF THE RNA SOCIETY, 19(10), 1449-1459 |
| J. H. Weng, M. R. Liang, C. H. Chen, S. K. Tong, T. C. Huang, S. P. Lee, Y. R. Chen, C. T. Chen*, and B. Chung (2013) Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration. NATURE CHEMICAL BIOLOGY, 9(10), 636-642 |
| T. K. Huang, C. L. Han, S. I. Lin, Y. J. Chen, Y. C. Tsai, Y. R. Chen, J. W. Chen, W. Y. Lin, P. M. Chen, T. Y. Liu, Y. S. Chen, C. M. Sun, and T. J. Chiou* (2013) Identification of Downstream Components of Ubiquitin-Conjugating Enzyme PHOSPHATE2 by Quantitative Membrane Proteomics in Arabidopsis Roots. Plant Cell, 25(10), 4044-4060 |
| C. J. Chen, W. Y. Chen, M. C. Tseng and Y. R. Chen* (2012) Tunnel Frit: A Nonmetallic In-Capillary Frit for Nanoflow Ultra High-Performance Liquid Chromatography-Mass Spectrometry Applications. ANALYTICAL CHEMISTRY, 84(1), 297-303 |
| M. Tsednee, Y. W. Mak, Y. R. Chen and K. C. Yeh* (2012) A sensitive LC-ESI-Q-TOF-MS method reveals novel phytosiderophores and phytosiderophore–iron complexes in barley. New Phytologist, 195(4), 951-961 |
| H. C. Tseng, H. W. Kao, M. R. Ho, Y. R. Chen, T. W. Lin, P. C. Lyu and W. C. Lin* (2011) Cytoskeleton network and cellular migration modulated by nuclear-localized receptor tyrosine kinase ROR1. Anticancer research, 31(12), 4239-4249 |
| C. J. Chen, M. C. Tseng, H. J. Lin, T. W. Lin and Y. R. Chen* (2010) Visual Indicator for Surfactant Abundance in MS-Based Membrane and General Proteomics Applications. ANALYTICAL CHEMISTRY, 82(19), 8283-8290 |
陳逸然
研究員
(02) 2787-2050
yetran@gate.sinica.edu.tw
辦公室：農科大樓 A531
實驗室
位置: 農科大樓 A523
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現職
2024-迄今 中央研究院農業生物技術研究中心研究員
2024-迄今 理事長, 台灣質譜學會
2016-迄今 國立嘉義大學化學系合聘副教授
2015-迄今 國立海洋大學生命科學系合聘副教授
2015-迄今 國立台灣大學生物科技所及系統生物學程合聘副教授
經歷
2015-2024 中央研究院農業生物技術研究中心副研究員
2007-2015 中央研究院農業生物技術研究中心助研究員
2006-2007 國立台灣海洋大學生物科技研究所助理教授
2002-2006 中央研究院化學研究所博士後研究
1998-2002 國立台灣大學化學研究所
榮譽
2024-迄今 常務理事, 台灣質譜學會
2015-迄今 理事, 亞太農業蛋白體學會
2014-迄今 理事, 台灣蛋白體學會
2015-2024 常務理事, 台灣質譜學會
2012-2015 理事, 台灣質譜學會
2012-2015 理事, 台灣質譜學會
2011-2014 理事, 台灣蛋白體學會
2006-2009 監事, 台灣質譜學會
獲獎
2016 中研院年輕學者研究著作獎
2016 中研院前瞻計畫獎
2016 林秋榮教授植物科學創新研究獎
2015 楊祥發院士傑出農業科學年輕學者獎
2013 台灣質譜學會年輕學者獎