Yu-Ling Lin

Yu-Ling Lin

Assistant Research Fellow

Mobilizing B Cells: Awakening Humoral Immunity with Natural Products to Combat Cancer and Immunosenescence
Mobilizing B Cells: Awakening Humoral Immunity with Natural Products to Combat Cancer and Immunosenescence

Publications

2026

Ho YF, Tsai YH, Jian TY, Lin HH, Shyur LF, Chang MT, Lin A, Zhan YZ, ( Lin YL )*
Phytogalactolipids triggered oxidative stress to inhibit drug-resistant colorectal cancer by suppressing interferon-α-induced protein 6. PHYTOMEDICINE , 153: 157960.
Jian TY, Huang SY, Chang CY, Huang CH, Kiew LV, ( Lin YL )*, Lin YT, Liu YC, Chen YC, Huang YX, Chou HS, Yap SF, Chen AY, Chen YC, Liang YC, Kung YA, Wang PY, Huang PN, Huang CG, Chang CC*, Shih SR*
HLA-C–derived peptide MH-1 as an early-stage intervention against SARS-CoV-2 infection. MOLECULAR MEDICINE , 32: 48.
Wu YS, Lin HH, Wu KS, Huang YT, Liao JY, Chu SS, Wong TT, Hsieh CL, Chang CC, Sung SY, Lin CY, ( Lin YL )*
7,7"-Dimethoxyagastisflavone induced MYCN/MYBL2-dependent apoptosis and metabolism reprogramming in Sonic Hedgehog medulloblastoma. JOURNAL OF TRANSLATIONAL MEDICINE , 24: 386.

2025

Do AD, Chu SS, Giang LH, Huang PL, ( Lin YL ), Chang CC, Wong TT, Sung SY, Hsieh CL*
Delivery of LOXL1-AS1-siRNAs using targeting peptide-engineered extracellular vesicles with focused ultrasound to suppress medulloblastoma metastasis. JOURNAL OF NANOBIOTECHNOLOGY , 23: 460.

2024

Giang LH, Wu KS, Lee WC, Chu SS, Do AD, Huang MH, ( Lin YL ), Hsieh CL, Sung SY, Yen Y, Wong TT, Chang CC*
RRM2 inhibition alters cell cycle through ATM/Rb/E2F1 pathway in atypical teratoid rhabdoid tumor. NEOPLASIA , 58: 101075.
Lin HH, YS Wu, Chang MT, Shyur LF, ( Lin YL )*
Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvant. VACCINE , 42 (4): 782.
Do AD, KS Wu, Chu SS, GL Hien, ( Lin YL ), Chang CC, Wong TT, Hsieh CL*, Sung SY*
LncRNA LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting TGFB2-mediated cell migration and cancer stem-like phenotypes. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH , 43: 130.

2023

Kimura K, Chun JH, ( Lin YL ), Liang YC, Jackson TLB, Huang RC*
Tetra-O-methyl- nordihydroguaiaretic acid inhibits energy metabolism and synergistically induces anticancer effects with temozolomide on LN229 glioblastoma tumors implanted in mice while preventing obesity in normal mice that consume high-fat diets.. PLOS ONE , 18(5): e0285536.
Chen CH, Weng TH, Huang HH, Huang LY, Huang KY, Chen PR, Yeh KY, Huang CT, Chien YT, Chuang PY, ( Lin YL ), Tsai NM, Liu SJ, Su YC, Weng SL*, Liao KW*
A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy.. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH , 42(1): 29.
Lin HH, YS Wu, Jian TY, Liao JY, Chang MT, Shyur LF*, ( Lin YL )*
Phytogalactolipids activate humoral immunity against colorectal cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH , 42(1): 95.

2022

Wu KS, Sung SY, Huang MH, ( Lin YL ), Chang CC, Fang CL, Wong TT, Chen HH, Tsai ML
Clinical and molecular features in medulloblastomas subtypes in children in a cohort in Taiwan. CANCERS , 14 (21): 5419.
Wu KS, Jian TY, Hsieh CL, Sung SY, Huang MH, Fang CL, Wong TT*, ( Lin YL )*
Subgroup-specific B cell enrichment in Group 4 medulloblastoma in children. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 23 (9): 5287.
Ke CH, Tomiyasu H, ( Lin YL ), Huang WH, Chiang HC, Lin CS
Canine transmissible venereal tumor established in immunodeficient mice reprograms the gene expression profiles associated with a favorable tumor microenvironment to enable cancer malignancy.. BMC VETERINARY RESEARCH , 18(1): 4.
Huang TH, Liu PY, ( Lin YL )*, Tsai JS*
Hypoglycemic peptide-enriched hydrolysates of Corbicula fluminea and Chlorella sorokiniana possess synergistic hypoglycemic activity through inhibiting a-glucosidase and dipeptidyl peptidase-4 activity. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE , 102(2): 716.

2021

Wu YS, Chen CR, Yeh YT, Lin HH, Peng YH, ( Lin YL )*
7,7-Dimethoxyagastisflavone inhibits proinflammatory cytokine release and inflammatory cell recruitment through modulating ERα signaling. BIOMEDICINES , 9: 1778.
Do AD, Kurniawati I, Hsieh CL, Wong TT, ( Lin YL ), Sung SY
Application of mesenchymal stem cells in targeted delivery to the brain: potential and challenges of the extracellular vesicle-based approach for brain tumor treatment. International Journal of Molecular Sciences , 22: 11187.
Chung CJ, Chuang YC, Lin CS, Wu YH, Lin HH, Hung PY, ( Lin YL )*, Liao KW*
Lycium chinense polysaccharide suppressed the hypertrophy and hyperplasia in adipocytes through regulating lipid and glucose metabolism. ACS Food Science & Technology , 1(6): 1014.
Chang KF, Huang XF, ( Lin YL ), Liao KW, Hsiao CY, Chang JT, Tsai NM*
Positively charged nanoparticle delivery of n-butylidenephthalide enhances antitumor effect in hepatocellular carcinoma. BIOMED RESEARCH INTERNATIONAL , 2021: 8817875.
Ke CH, Hsu CH, ( Lin YL ), Huang WH, Weng HP, Ke YT, Lin CS
Curcumin and freshwater clam extracts alleviate the progression of osteoarthritis by reducing synovial inflammation and allowing cartilage regeneration. Processes , 9(6): 931.
Huang XF, Chang KF, ( Lin YL ), Liao KW, Hsiao CY, Sheu GT, Tsai NM*
Enhancement of cytotoxicity and induction of apoptosis by cationic nano-liposome formulation of n-butylidenephthalide in breast cancer cells. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES , 18 (13): 2930.
Huang XF, Chen PT, ( Lin YL ), Lee MS, Chang KF, Liao KW, Sheu GT, Hsiao MC, Tsai NM
Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers of n butylidenephthalide in leukemia cells. CLINICAL & TRANSLATIONAL ONCOLOGY , 23 (6): 1142.

2020

( Lin YL ), Huang XF, Chang KF, Liao KW, Tsai NM*
Encapsulated n-butylidenephthalide efficiently crosses the blood–brain barrier and suppresses growth of glioblastoma . International Journal of Nanomedicine , 15: 749.
Chang KF, Chang JT, Huang XF, ( Lin YL ), Liao KW, Huang CW, Tsai NM*
Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells. MOLECULES , 25(10): 2394.

2019

Lin YL , Tsai NM, Chen CH, Liu YK, Lee CJ, Chan YL, Wang YS, Chang YC, Lin CH, Huang TH, Wang CC, Chi KH, Liao KW*
Specific drug delivery efficiently induced human breast tumor regression using a lipoplex by non-covalent association with anti-tumor antibodies. Journal of nanobiotechnology , 17(1): 25.
Lin YL , Chen CH, Liu YK, Huang TH, Tsai NM, Tzou SC, Liao KW*
Lipo-PEG-PEI complex as an intracellular transporter for protein therapeutics. International Journal of Nanomedicine , Volume 14, 1119-1130
Chiu PL, Chang CH, Lin YL , Tsou PH, Li BR*
Rapid and Safe Isolation of Human Peripheral Blood B and T Lymphocytes through Spiral Microfluidic Channels. Scientific Reports , 9(1), 8145