2026

Shiau, J.-Y., Huang, H.-J., Nakagawa-Goto, K., and Shyur, L.-F. *

Integrated proteomics and metabolomics reveal phytosesquiterpene lactones DET and DETD-35 inhibit triple-negative breast cancer cell activity by depleting ATP synthesis and reprogramming primary metabolism. Scientific Reports , 16: 5264

Wang, X., Li, H., Jiang, S., Yang, N., Wang, D., Xu, H., Robinson, N., Shyur, L.-F. , Heinrich, M., Wang, M., Simmonds, M.S.J., Zhong, L., Brahmi, F., Efferth, T., Amuri, S. B., Lau, C. B.-S., Wong, W., Bauer, R., Duez, P., and Xu, Q.

Traditional, complementary and integrative medicine: A scoping review of international standards and good practice guidelines. Frontiers in Pharmacology , 17, 1742400

2025

Vong, S.-K., Chen, C.-M., Das, A., Shyur, L.-F. , Ju, Y.-M., Hsieh, H.-M., Yang, S.-H., Varga, V., and Li, S.-C.*

Stimulation of glucose uptake by edible Pholiota nameko (T.Itô) S.Ito & S.Imai extract counteracts palmitate-induced insulin resistance in C2C12 myotubes.. Frontiers in Sustainable Food Systems , Volume 9, doi.org/10.3389/fsufs.2025.1520875

2024

Wang, J.-E. and Shyur, L.-F. *

The functional role of N-link glycosylation in a novel cellobiohydrolase II (LsCel6A) from a white-rot fungus Lentinus sp. WR2. International Journal of Biological Macromolecules , 283, 137771

Chang, C.-T., Chen, Y.-H., and Shyur, L.-F. *

Phytocompounds from essential oil of Mentha aquatica Lime Mint prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRASQ61L keratinocyte and reprogramming macrophage activities. Phytomedicine , 122, 155161

Lien, Y.-Y.#, Shyur, L.-F. #, Cheng, Y.-B., Chang, M.-T., Chang, C.-T., Chen, Y.-H., Lai, G.-H., Liao, H.-Y., and Cheng, M.-C.*

Trifolium pratense as a novel phytogenic supplement, is an anticoccidial agent in chickens. . Poultry Science , 103, 104064. (To be honored as the “Best Researcher Award” of the journal)

Cheng, Y.-T., Chang, D.-M., Tung, Y.-C., Hsiao, P.-W., Nakagawa-Goto, K., and Shyur, L.-F. *

Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis.. Phytomedicine , 135, 156226

Pan, Y.-C., Chu, P.-Y., Lin, C.-C., Hsieh, C.-Y., Hsu, W.-Y., Shyur, L.-F. , Yang, J.-C., Chang, W.-C., and Wu, Y.-C.*

Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer. Molecular Oncology , 18, 1866-1884

Lin, H.-H., Wu, Y.-S., Chang, M.-T., Shyur, L.-F. , and Lin, Y.-L.*

Plant-derived galactolipids enhance specific antibody production and induce class-switch as vaccine adjuvant. Vaccine , 42, 782-794

2023

Lin, H.-H, Wu, Y.-S., Jian, T-Y., Laio, J.-Y., Chang, M.-T., Shyur, L.-F. *, and Lin, Y.-L.*

Phytogalactolipids activate humoral immunity against colorectal cancer. Journal of Experimental & Clinical Cancer Research , 42, 95

Cheng, Y.-T., Nakagawa-Goto, K., Lee, K.-H., and Shyur, L.-F. *

miRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones. Antioxidants & Redox Signaling , 38, 198-214

Ho, Y.-F. Ho, Shiau, J.-Y., Sri Malek, A. M., Shyur, L.-F. *, and Saiful, A. K.*

Quantitative proteomic analysis of differential proteins in helichrysetin-treated human lung carcinoma cells, A549. Applied Biochemistry and Biotechnology , DOI:10.1007/s12010-023-04384-2

Valdez, G., Shyur, L.-F. , Wang, S.-Y.*, and Chen, S.-E.*

Phytogenics in ginger, Origanum vulgare, and Syzygium aromaticum and their potential as a feed additive against Clostridium perfringens in broiler production. Animals , 13, 3643

Tsao, C.-H., Hsieh, W.-C., Lin, F.-J., Yang, R.-Y., Chang, M.-T., Apaya, M. K., Shyur, L.-F. , Ke, L.-Y., Zouboulis, C. C., and Liu, F.-T.*

The critical role of galectin-12 in modulating lipid metabolism in sebaceous glands. Journal of Investigative Dermatology , 143, 913-924

2022

Chang, M.-T., Tsai, L.-C., Nakagawa-Goto, K., Lee, K.-H., and Shyur, L.-F. *

Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib resistant melanoma via GPX4 inhibition and metabolic reprogramming. Pharmacological Research , 178, 106148

Chiang, K.-M., Chen, J.-F., Yang, C.-A., Xiu, L., Yang, H.-C., Shyur, L.-F. , and Wen-Harn Pan

Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study. metabolites , 12, 495

Wei, W.-C., Shyur, L.-F. , and Yang, N.-S.*

Cellular and molecular signaling as targets for cancer vaccine therapeutics.. cells , 111, 590

2021

Wu, T.-N., Chen, H.-M., and Shyur, L.-F. *

Current advancements of plant-derived agents for triple-negative breast cancer therapy through deregulating cancer cell functions and reprogramming tumor microenvironment. International Journal of Molecular Sciences , 22, 13571

Yang, C.-C., Chang, M.-M., Chang, C.-K., and Shyur, L.-F. *

Phytogalactolipid dLGG inhibits mouse melanoma brain metastasis through regulating oxylipin activity and re-programming macrophage polarity in the tumor microenvironment. Cancers , 13(16), 4120

Cvetanova, B., Li, M.-Y., Yang, C.-C., Hsiao, P.-W., Yang, Y.-C., Feng, J.-H., Shen, Y.-C., Nakagawa-Goto, K., Lee, K.-H., and Shyur, L.-F. *

Sesquiterpene lactone deoxyelephantopin isolated from Elephantopus scaber and its derivative DETD-35 suppress BRAFV600E mutant melanoma lung metastasis in mice. International Journal of Molecular Sciences , 22(6), 3226

Shyur, L.-F. #, Varga V.#, Chen, C.-M., Mu, S.-C., Chang, Y.-C., and Li, S.-C.*

Extract of white sweet potato tuber against TNF-α-induced insulin resistant by activating the PI3K/Akt pathway in C2C12 myotubes. BOTANICAL STUDIES , 62,, 7

2020

Chung, H.-H., Ting, H.-M., Wang., W.-H., Chao, Y.-T., Hsieh, C.-H., Apaya, M. K., Sung, Y.-C., Lin, S.-S., Hwu, F.-Y., and Shyur, L.-F. *

Elucidation of enzymes involved in the biosynthetic pathway of bioactive polyacetylenes in Bidens pilosa using integrated omics approaches. Journal of Experimental Botany , doi:10.1093/jxb/eraa457, 10

Chen, P.-Y., Hsieh, M.-J., Tsai, Y.-T., Chung, H.-H., Shyur, L.-F. , Hsieh, C.-H., and Kin-Ying To*

Transformation and characterization of 12-fatty acid acetylenase and 12-oleate desaturase potentially involved in the polyacetylene biosynthetic pathway from Bidens pilosa. Plants , 9, 1483

Huang C.-C., Chang, M.-T., Leu, H.-B., Yin, W.-H., Tseng, W.-K., Wu, Y.-W., Lin, T.-H., Yeh, H.-I, Chang, K.-C., Wang, J.-H., Wu, C.-C., Shyur, L.-F. *, and Chen, J.-W.*

Association of arachidonic acid-derived lipid mediators with subsequent onset of acute myocardial infarction in patients with stable coronary artery disease. SCIENTIFIC REPORTS , 10, 8105

Apaya, M. K., Hsiao, P.-W., Yang, Y.-C., and Shyur, L.-F. *

Deregulating the CYP2C19/epoxyeicosatrienoic acid-associated FABP4/FABP5 signaling network as a therapeutic approach for metastatic triple negative breast cancer. Cancers , 12, 199

Shih, C.-K., Chen, C.-M., Varga, V., Shih, L.-C., Chen, P.-R., Lo, S.-F., Shyur, L.-F. , and Li, S.-C.

White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice. Food & Nutrition Research , 64, 3609

2019

Cvetanova, B., Shen, Y.-C., and Shyur, L.-F. *

Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death. Frontiers in Pharmacology , 10

Wen-Wan Chao, Ya-Wen Cheng, Yet-Ran Chen, Shu-Hua Lee, Ching-Yi Chiou, Lie-Fen Shyur

Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity. Phytomedicine , 56, 194–206

Chang, C.-T., Soo, W.-N., Chen, Y.-H., and Shyur, L.-F. *

Essential oil of Mentha aquatica var. Kenting Water Mint suppresses two-stage skin carcinogenesis accelerated by BRAF inhibitor vemurafenib.. Molecules , 24, 2344

Apaya Maria Karmella, Shiau Jeng-Yuan, Liao Guo-Shiou, Liang Yu-Jen, Chen Chia-Wei, Yang Hsin-Chou, Chu Chi-Hong, Yu Jyh-Cherng, Shyur Lie-Fen

Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer. Journal of Experimental & Clinical Cancer Research , 38(1), 187

2018

Yang, C.-C., Chang, C.-K., Chang, M.-T. , and Shyur, L.-F. *

Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-alpha-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice. International Journal of Cancer , 143, 3248–3261

Hsu, S.-F., Lee, Y.-B., Lee, Y.-C., Chung, A.-L., Apaya, K. M., Shyur, L.-F. , Cheng, C.-F., Ho, F.-M., and Meng, T.-C.

Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1. The FEBS Journal , 285(9), 1593-1610

2017

Hua, M. D., Senthil Kumar, R., Shyur, L.-F. , Cheng, Y.-B., Tian, Z., Oelmüller, R. and Yeh, K.-W.

Metabolomic compounds identified in Piriformospora indica-colonized Chinese cabbage roots delineate symbiotic functions of the interaction. Scientific Reports , 7, 9291

Shang, K.-M., Su, T.-H., Lee, W. L., Hsiao, W.-W., Chiou, C.-Y., Ho, B.-Y., Wang, S.-Y., and Shyur, L.-F. *

Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer. Phytomedicine , 24, 39-48

Shiau, J.-Y., Nakagawa-Goto, K., Kuo-Hsiung Lee, K.-H., Shyur, L.-F. *

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death. Oncotarget , 8(34), 56942-56958

Shiau, J.-Y., Chang, Y.-Q., Nakagawa-Goto, K., Kuo-Hsiung Lee, K.-H., Shyur, L.-F. *

Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions. Frontiers in Pharmacology , 8, 398

2016

Maria Karmella Apaya, Meng-Ting Chang, Lie-Fen Shyur *

Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics. Pharmacology and Therapeutics , 162, 58-68

Nakagawa-Goto, K., Chen, J.-Y.,　Cheng, Y.-T., Lee, W.-L., Takeya, M., Saito, Y., Lee, K.-H., and Shyur, L.-F. *

Novel sesquiterpene lactone analogues as potent anti-breast cancer agents . Molecular Oncology , 10(6), 921-937

Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, and Lie-Fen Shyur *

A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice. MOLECULAR CANCER THERAPEUTICS , 15(6), 1163-1176

Cheng, Y.-T., Yang, C.-C., and Shyur, L.-F. *

Phytomedicine-Modulating oxidative stress and the tumor microenvironment for cancer therapy . Pharmacological Research , 114, 128-143

Lee, H.-M., Patela, V., Shyur, L.-F. , and Lee, W. L.

Copper supplementation amplifies the anti-tumor effect of curcumin in oral cancer cells. Phytomedicine , 23(12), 1535-1544

2015

Liu, W.-C., Maestre-Reyna, M., Jeng, W.-Y., Lee, C.-C., Hsu, C.-A., Wen, T.-N., Wang, A. H.-J.*, and Shyur, L.-F. *

Structural and functional roles of glycosylation in fungal laccase from Lentinus sp . PLoS ONE , 10(4), UNSP e0120601

Apaya, M. K., Lin, C.-Y., Chiou, C.-Y., Yang, C.-C., Ting, C.-Y., and Shyur, L.-F. *

Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway. Molecular Medicine , 21, 988-1001

Deng, Y.-T., Lin-Shiau, S.-Y. Shyur, L.-F. , and Lin, J.-K.*

Pu-erh tea polysaccharides decrease blood sugar by inhibition alpha-glucosidase activities in vitro and in mice. Food & Function , 6(5), 1539-1546

Cheng, Y.-B., Lo, I-W., Shyur, L.-F. , Yang, C.-C., Hsu, Y.-Mi., Su, J.-H., Lu, M.-C., Chiou, S.-F., Lan, C.-C., Wu, Y.-C., Chang, F.-R.

New alkaloids from Formosan zoanthid Zoanthus kuroshio. Tetrahedron , 71, 8601-8606

Shiau, J.-Y., Yin, S.-Y., Chang, S.-L., Hsu, Y.-J., Chen, K.-W., Kuo, T.-F., Feng, C.-S., Yang, N.-S., Shyur, L.-F. *, Yang, W.-C.*, and Wen, T.-N.*

Mechanistic study of the phytocompound, 2-beta-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches. Evidence-based Complementary and Alternative Medicine , 475610

Wei, W.-C., Liu, C.-P., Yang, W.-C., Shyur, L.-F. , Sheu, J.-H., Chen, S.-S., and Yang, N.-S.

Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells. Journal of Leukocyte Biology , 97(6), 1071-1080

2013

Lee, W.-L., Huang, J.-Y., and Shyur, L.-F. *

Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxidative Medicine and Cellular Longevity , 2013, 925804

Liao, G.-S., Apaya, M. K., and Shyur, L.-F. *

Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy. Evidence-based Complementary and Alternative Medicine , 2013, 437948

Huang, C.-C., Lin, K.-J., Cheng, Y.-W., Hsu, C.-A., Yang, S.-S., and Shyur, L.-F. *

Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis. Journal of Nutritional Biochemistry , 24(3), 516-530

Chou#, T.-W., Feng#, J.-H., Huang, C.-C., Cheng, Y.-W., Chien, S.-C., Wang, S.-Y.*, and Shyur, L.-F. *

A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice. PLoS ONE , 8(10), e77626

2012

Lee, W.-L., Shiau, J.-Y., and Shyur, L.-F. *

Taxol, camptothecin and beyond for cancer therapy . Advances in Botanical Research , 62, 133-178

Ho, B.-Y., Lin, C.-H., Apaya, M. K., Chao, W.-W., and Shyur, L.-F. *

Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice. Journal of Traditional and Complementary Medicine , 2(4), 301-311

Hung, S.-W., Chiu, C.-F., Chen, T.-A., Chu, C.-L., Huang, C.-C., Shyur, L.-F. , Liang, C.-M., and Liang, S.-M

Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer. Breast Cancer Research and Treatment , 136, 89-105

Liu, W.-C., Lin, Y.-S., Jeng, W.-Y., Chen, J.-H., Wang, A. H.-J., and Shyur, L.-F. *

Engineering of dual functional hybrid glucanases. Protein Engineering Design & Selection , 25(11), 771-780

Lee, W.-L. and Shyur, L.-F. *

Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation . Free Radical Biology & Medicine , 52, 1423-1436

Chen, S.-C., Wu, P.-H., Su, Y.-C., Wen, T.-N., Wei, Y.-S., Wang, N.-C., Hsu, N.-C., Wang, Andrew H.-J., and Shyur, L.-F. *

Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1. Protein Engineering Design & Selection , 25(11), 761-769

Hsu, C.-A., Wen, T.-N., Su, Y.-C., Jiang, Z.-B., Chen, C.-W., and Shyur, L.-F. *

Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp . Environmental Science and Technology , 46, 5109-5117

2011

Wen, C.-C.#, Shyur, L.-F. #, Jan, J.-T.#, Liang, P.-H., Kuo, C.-J., Arulselvan, P., Wu, J.-B., Kuo, S.-C., and Yang, N.-S.

Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. Journal of Traditional and Complementary Medicine , 1, 41-50

Tsai, L.-C., Hsiao, C.-H., Liu, W.-Y., Yin, L.-M., and Shyur, L.-F.

Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors. Biochemical and Biophysical Research Communication , 407, 593-598

Su, P.-F., Li, C.-J., Hsu, C.-C., Benson, S., Wang, S.-Y., Chan, S. I., Wu, S.-H., Huang, W.-C., Shyur, L.-F. *, and Yang, N.-S.*

Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo. Evidence-based Complementary and Alternative Medicine , 44572

Jeng, W.-Y., Wang, N.-C., Lin, C.-T., Shyur, L.-F. , and Wang, H.-J. A.

Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection. Journal of Biological Chemistry , 286, 45030-45040

Shyur, L.-F. *, Huang, C.-C., Hsu, Y.-Y., Cheng, Y.-W., Yang, S.-D.

A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression. Phytochemistry , 72(4-5), 391-399

Hou, C.-C., Huang, C.-C., and Shyur, L.-F. *

Echinacea alkamides prevent lipopolysaccharide/D-galactosamineinduced acute hepatic injury through JNK pathway-mediated HO-1 expression. Journal of Agricultural and Food Chemistry , 59, 11966-11974

2010

Shyur, L.-F. *, Yang, N.-S., Kang, P.-L., Sun, S.-J., Wang, S.-Y.

Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment. Malaysia patent , issued No. PI20032638

Shyur, L.-F. *, Lee, S.-H., Chang, S.-T., Lo, C.-P., Kuo, Y.-H., and Wang, S.-Y.

Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways. Phytomedicine , 18, 16-24

Chen, J.-H., Tsai, L.-C., Huang, H.-C., and Shyur, L.-F. *

Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase. PROTEINS: Structure, Function, and Bioinformatics , 78, 2820-2830

Huang, C.-C., Lo, C.-P., Chiu, C.-Y., and Shyur, L.-F. *

Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice. British Journal of Pharmacology , 159, 856-871

Hsan, K. M., Chen, C.-C., and Shyur, L.-F. *

Current research and development of chemotherapeutic agents for melanoma. Cancers , 2, 397-419

Wai-Leng Lee, Tuan-Nan Wen, Jeng-Yuan Shiau, and Lie-Fen Shyur

Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells. Journal of Proteome Research , 9(1), 237-253.

Hou, C.-C., Chen, C.-H., Yang, N.-S., Lo, C.-P., Wang, S.-Y., Tien, Y.-J., Tsai, P.-W. and Shyur, L.-F. *

Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants. Journal of Nutritional Biochemistry , 21(11), 1045-59

2009

Shyur, L.-F. *, Yang, N.-S., Kang, P.-L., Sun, S.-J., Wang, S.-Y.

Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for tumor prevention/treatment. Australia patent issued No. AU 2003244587 , 澳洲專利

Shyur, L.-F. *, Chen, J.-L., and Yang, N.-S.

Truncated glucanase with enhanced activity and method for making the same. (US patent issued No. 7037696) (ROC patent issued No. 201683) (Two technology licensing/transfer to local biotech companies) , No. 7037696 and No. 201683

Shyur, L.-F. *, Wen, T.-N., Lee, S.-H., and Yang, N.-S.

Truncated 1,3-1,4-beta- D-glucanase. US patent issued No. 7,527,958 , No. 7,527,958

Lin, Y.-S., Tsai, L.-C., Lee, S.-H., Yuan, H. S., and Shyur, L.-F. *

Structural and catalytic roles of residues located in beta-13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS , 1790(4), 231-239

Shyur, L.-F. *, Hou, C.-C., Wu, J.-H., Chen, Y.-P., Wang, S.-Y., Huang, C.-C., and Yang, N.-S.

Cancer and inflammatory disorder treatment. S patent issued No. 7547455 and ROC patents pending , No. 7547455

2008

Yang, W.-C., Chang, S.-L., Chang, L.-T., Chiang, Y.-M., and Shyur, L.-F.

Pure compounds (2-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-triyne and 3-D- glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne) and n-butanol fraction from Bidens pilosa Linn var radiate can prevent Th1-mediated autoimmune disease via suppressing Th1 cell differentiation and/or promoting Th2 cell differentiation. (US and ROC patents pending) (One technology licensing/transfer to local biotech company)

Yang, W.-C., Chang, S.-L., Chiang, Y.-M., and Shyur, L.-F.

Immunomodulatory phytocompounds and the highly efficient platform to screen the same. US patent pending

Tsai, L.-C.*, Huang, H.-C., Hsiao, C.-H., Chiang, Y.-N., Shyur, L.-F. *, Lin, Y.-S., and Lee, S,-H.

Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY , D64, 1259–1266

Yang, N.-S., Su, P.-F., Li, C.-J., and Shyur, L.-F.

Methods for enhancing proliferation of bone marrow cells or spleen cells with an ethanol-insoluble extract of Dioscorea. (US patent issued No: 7,419,690 B2; ROC patent pending) (One technology licensing/transfer to local biotech company) , No, 7,419,690 B2

Shyur, L.-F. * and Yang, N.-S.*

Metabolomics for phytomedicine research and drug development . CURRENT OPINION IN CHEMICAL BIOLOGY , 12, 66-71

Shyur, L.-F. *, Huang, C.-C., Lo, C.-P., Chiu, C.-Y., Chen, Y.-P., Wang, S.-Y., and Chang, S.-T.

Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators. PHYTOCHEMISTRY , 69, 1348-1358

Wang, C.-Y., Staniforth, V., Chiao, M.-T., Hou, C.-C., Wu, H.-M., Yeh, K.-C., Chen, C.-H., Hwang, P.-I., Wen, T.-N., Shyur, L.-F. *

Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells. BMC Genomics , 9, 479-498

Wu, J.-H., Tung, Y.-T., Chien, S.-C., Wang, S.-Y., Kuo, Y.-H., Shyur, L.-F. *, and Chang, S.-T.*

Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production. Journal of Agricultural and Food Chemistry , 56, 1567-1573

Lin, F.-M., Tsai, C.-H., Yang, Y.-C., Tu, W.-C., Chen, L.-R., Liang, Y.-S., Wang, S.-Y., Shyur, L.-F. , Chien, S.-C., Cha, T.-L., Hsiao, P.-W.

A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis. Cancer Research , 68, 6634-6642

Su, P.-F., Staniforth, V., Li, Ch.-J., Wang, C.-Y., Chiao, M.-T., Wang, S.-Y., Shyur, L.-F. , and Yang, N.-S.

Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues. Journal of Biomedical Science , 15(6), 813-22

Tsai, L.-C.*, Chen, Y.-N. and Shyur, L.-F.

Structural modeling of glucanasesubstrate complexes reveals residue Tyr177 in barley 1,3-1,4-beta-D-glucanase plays an important role in carbohydrate recognition . Journal of Computer-Aided Molecular Design , 22(12), 915-923

2007

C.-C. Wen, Y.-H. Kuo, J.-T. Jan, P.-H. Liang, S.-Y. Wang, H.-G. Liu, C.-K. Lee, S.-T. Chang, C.-J. Kuo, S.-S. Lee, C.-C. Hou, P.-W. Hsiao, S.-C. Chien, L.-F.* Shyur and N.-S.* Yang

Specific terpenoids and lignoids possess antiviral activities against SARS coronavirus. Journal of Medicinal Chemistry , 50, 4087-4095

Wen, C.-C., Kuo, Y.-H., Jan, J.-T., Liang, P.-H., Wang, S.-Y., Liu, H.-G., Lee, C.-K., Chang, S.-T., Kuo, C.-J., Lee, S.-S., Hou, C.-C., Hsiao, P.-W., Chien, S.-C., Shyur, L.-F. and Yang, N.-S.

Specific plant terpenoids and lignoids possess antiviral activities against SARS coronavirus. Journal of Medicinal Chemistry , 50(17), 4087-4095

Chang, S.-L., Chiang, Y.-M., Chang, C.-L., Yeh, H.-H., Shyur, L.-F. , Kuo, Y.-H., Wu, T.-K., and Yang, W.-C.*

Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. Journal of Ethnopharmacology , 112, 232-236

Hsieh, Y.-H., Kuo, P.-M., Chien, S.-C., Shyur, L.-F. , and Wang, S.-Y.

Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide. Phytomedicine , 14, 675-680

Chiang, Y.-M., Cicero L.-T., Chang, S.-L., Yang, W.-C.*, and Shyur, L.-F. *

Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. Journal of Ethnopharmacology , 110, 532-538

Hou, C.-C., Chen, Y.-P., Wu, J.-H., Huang, C.-C., Wang, S.-Y., Yang, N.-S., and Shyur, L.-F. *

A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma . Cancer Research , 67, 6907-6915

Wu, L.-W., Chiang, Y.-M., Chuang, H.-C., Lo, C.-P., Yang, K.-Y., Wang, S.-Y., and Shyur, L.-F. *

A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7. Planta Medica , 73, 655-661.

2006

Shyur, L.-F. *, Yang, N.-S., Kang, P.-L., Sun, S.-J., Wang, S.-Y.

Use of Anoectochilus formosanus plant extracts and their derived fractions as herbal medicines or nutraceutical supplements for chemoprevention or treatment of human malignancies. (US patent issued No. 7033617; Singapore patent issued No. 120937; PRC patent issued No. CN ZL03158682. 1) (One technology licensing/transfer to local biotech company) , 7033617

Wang, C.-Y., Chiao, M.-T., Yen, P.-J., Huang, W.-C., Hou, C.-J., Chung, S.-C., Yeh, K.-C., Shyur, L.-F. *, and Yang, N.-S.*

Modulatory effects of Echinacea purpurea extracts on human dendritic cells: A cell- and gene-based study. Genomics , 88(6), 801-808

2005

C. L. Chang, H. K. Kuo, S. L. Chang, Y. M. Chiang, T. H. Lee, W. M. Wu, L. F. Shyur and W. C. Yang

The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice. Journal of Biomedical Science , 12, 79-89

J. H. Wu, Y. T. Tung, S. Y. Wang, L. F. Shyur , Y. H. Kuo and S. T. Chang

Phenolic antioxidants from the heatwood of Acacia confusa. Journal of Agricultural and Food Chemistry , 53, 5917-5921

Y. M. Chiang, C. P. Lo, Y. P. Chen, S. Y. Wang, N. S. Yang, Y. H. Kuo and L. F. Shyur

Ethyl caffeate suppresses NF-B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. British Journal of Pharmacology , 146, 352-363

L. C. Tsai, L. F. Shyur , Y. S. Cheng S. H. Lee

Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose. J Mol Biol , 354, 642-651

S. Y. Wang, C. L. Wu, F. H. Chu, S. C. Chien, Y. H. Kuo, L. F. Shyur and S. T. Chang

Chemical composition of the wood essential oil of Chamaecyparis formosensis Matsum and its antifungal activity. Holzforschung , 59, 295-299

T. N. Wen, J. L. Chen, S. H. Lee, N. S. Yang and L. F. Shyur

A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance. Biochemistry , 44, 9197-9205

Wen, T.-N., Chen, J.-L., Lee, S.-H., Yang, N.-S. and Shyur, L.-F. .*

A 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes with improved enzymatic activity and thermotolerance. Biochemistry , 44, 9197-9205

2004

Staniforth, V., Wang, S.-Y., Shyur, L.-F. and Yang, N.-S.*

Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. Journal of Biological Chemistry , 279(7), 5877-5885

S. L. Chang, C.L.T. Chang, Y. M. Chiang, R. H. Hsieh, C. R. Tzeng, T. K. Wu, H. K. Sytwu, N. S. Yang, L. F. Shyur and W. C. Yang

Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice. Planta Medica , 70, 1045-1051

Wu, L.-W.*, Chiang, Y.-M., Chuang, H.-C., Wang, S.-Y., Yang, G.-W., Chen, Y.-H., Lai, L.-Y. and Shyur, L.-F. *

Polyacetylenes function as anti-angiogenic agents. Pharmaceutical Research , 21, 2112-2119

Y. M. Chiang, D. Y. Chuang, S. Y. Wang, Y. H. Kuo, P. W. Tsai and L. F. Shyur

Metabolite Profiling and Chemopreventive Bioactivity of Plant Extracts from Bidens pilosa. Journal of Ethnopharmacology , 95, 409-419

N. S. Yang, L. F. Shyur , C. H. Chen, S. Y. Wang and C. M. Tzeng

Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells. Journal of Biomedical Science , 11, 418-422

Shyur, L.-F. *, Chen, C.-H., Lo, C.-P., Wang, S.-Y., Kung, P.-L., Sun, S.-J., Chang, C. Allen, Tzeng, C.-M. and Yang, N.-S.

Induction of specific apoptotic pathways in MCF-7 cells by phytochemicals from medicinal herb Anoectochilus formosanus. Journal of Biomedical Science , 11, 928-939

Shyur, L.-F. *, Chen, C.-H., Lo, C.-P., Wang, S.-Y., Kung, P.-L., Sun, S.-J., Chang, C. Allen, Tzeng, C.-M. and Yang, N.-S.

Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus. J. Biomed. Sci. , 11, 928-939

S. Y. Wang, J. H. Wu, S. S. Cheng, C. P. Lo, H. N. Chang, N. S. Yang, L. F. Shyur and S. T. Chang

Antioxidant Activity of Extracts from Calocedrus formosana Leaf, Bark and Heartwood. JOURNAL OF WOOD SCIENCE , 50, 422-426

2003

Wang, J.-H., Lin, K.-F., Benson, S. A., Sun, S.-J., Cheng, W.-M., Wang, S.-Y., Shyur, L.-F. and Yang, N.-S.*

Tissue Array Transgene Expression System for the Evaluation of Effect of Medicinal Herbs on Wound-healing. J. Genet. Mol. Biol. , 14, 133-144

V. Staniforth, S. Y. Wang, L. F. Shyur and N. S. Yang

Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. Journal of Biological Chemistry , 279, 5877-5885

L. C. Tsai, L. F. Shyur , S. H. Lee, S. S. Lin and S. H.Yuan

Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes. JOURNAL OF MOLECULAR BIOLOGY , 330, 607-620

S. Y. Wang, H. N. Chang, K. T. Lin, C. P. Lo, N. S. Yang and L. F. Shyur

Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica. Journal of Agricultural and Food Chemistry , 51, 1506-1512

2002

S. Y. Wang, Y. H. Kuo, H. N. Chang, H. S. Tsay, K. F. Lin, N. S. Yang and L. F. Shyur

Profiling and characterization of antioxidant activities in Anoectochilus formosanus Hayata. Journal of Agricultural and Food Chemistry , 50, 1859-1865

H. L. Cheng, L. C. Tsai, S. S. Lin, H. S. Yuan, N. S. Yang, S. H. Lee and L. F. Shyur

Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme. Biochemistry , 41, 8759-8766

2001

J. L. Chen, L. J. Tsai, T. N. Wen, J. B. Tang, S. H. Yuan and L. F. Shyur

Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-b-D-glucanase significantly affects catalysis and enzyme structural stability. Journal of Biological Chemistry , 276, 17895-17901

L. C. Tsai, L. F. Shyur , S. S. Lin and H. S. Yuan

Crystallization of the 1,3-1,4-b-D-glucanase from Fibrobacter succinogenes. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY , 57, 1303-1306

S. Y. Wang, J. H. Wu, L. F. Shyur , Y. H. Kuo and S. T. Chang

Antioxidant Activity of Abietane-Type Diterpenes from Heartwood of Taiwania cryptomerioides Hayata. Holzforschung , 56, 487-492