ABRC
| Published Papers (2025-8-29) MYADM Activates RhoA-Mediated Ameboid Migration to Drive Metastasis more Cancer Research | |
| Published Papers (2025-4-28) PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis more Cancer Discovery | |
| Published Papers (2025-11-28) Metabolomics-Based Liquid Biopsy for Predicting Clinically Significant Prostate Cancer more Cancers | |
| Published Papers (2024-10) Vaccine optimization for highly pathogenic avian influenza: Assessment of antibody responses and protection for virus-like particle vaccines in chickens more Vaccine: X | |
| Published Papers (2024-05-22) Predicting Clinically Significant Prostate Cancer Using Urine Metabolomics via Liquid Chromatography Mass Spectrometry more The World Journal of Men's Health | |
| Published Papers (2024-05-03) Assessment of Anti-Prostate Cancer Activity among Four Seaweeds, with Focus on Caulerpa lentillifera J.Agardh more Foods | |
| Published Papers (2024-04-12) Development of a Novel, Potent, and Selective Sialyltransferase Inhibitor for Suppressing Cancer Metastasis more International Journal of Molecular Sciences | |
| Published Papers (2023-10-11) Prediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated study more Journal of Translational Medicine | |
| Published Papers (2023-08) Pilot-scale production of inactivated monoglycosylated split H1N1 influenza virus vaccine provides cross-strain protection against influenza viruses more Antiviral Research | |
| Published Papers (2023-05-16) Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells more eLife | |
| Published Papers (2023-01-03) Immunoediting instructs tumor metabolic reprogramming to support immune evasion more Cell Metabolism | |
| Published Papers (2022-07-06) Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression more JOURNAL OF HEMATOLOGY & ONCOLOGY | |
| Published Papers (2022-04-13) Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis more ONCOGENE | |
| Published Papers (2021) Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice more International Journal of Molecular Sciences | |
| Published Papers (2021) CD28 engagement inhibits CD73-mediated regulatory activity of CD8+T cells more Communications Biology | |
| Published Papers (2021) Comparison of Chicken Immune Responses after Inoculation with H5 Avian Influenza Virus-like Particles Produced by Insect Cells or Pupae more JOURNAL OF VETERINARY RESEARCH | |
| Published Papers (2021) Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells more NATURE COMMUNICATIONS | |
| Published Papers (2021) Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAF V600E Mutant Melanoma Lung Metastasis in Mice more International Journal of Molecular Sciences | |
| Published Papers (2021) Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis more Journal of Medicinal Chemistry | |
| Issued Patents TRANSCRIPTION MODULATOR COMPOSITIONS more USA-regular US 9144591 蕭培文 | |
| Issued Patents 產生類病毒微粒之高產率轉殖基因哺乳動物表現系統 more Taiwan TWI 494430 蕭培文,吳佳穎,葉怡均 | |
| Issued Patents High yield transgenic mammalian expression system for generating virus-like particles more USA-regular US 8980281 蕭培文,吳佳穎,葉怡均 | |
| Issued Patents 二帖類化合物於治療攝護腺癌之用途 more Taiwan TWI 434680 蕭培文,林楓閔,王升陽 | |
| Issued Patents Transcription Modulator Compositions more USA-regular US8,597,701 B2 蕭培文 | |
| Issued Patents Use of diterpene,6-hydroxy-5,6-dehydrosugiol,and its derives in treatment of prostate cancer more USA-regular US8519007 蕭培文,林楓閔,王升陽 | |
| Issued Patents 轉錄調控組合物 more Taiwan TW I 405966 蕭培文 | |
| Issued Patents Transcription Modulator Compositions more China CN 101313926B 蕭培文 | |
| Issued Patents 產生類病毒微粒之高產率轉殖基因哺乳動物表現系統 more Taiwan TW I 340166 蕭培文,楊寧蓀,黃銓珍,林恩豪 | |
| Issued Patents 轉錄調控物組合物 more Taiwan TW I324521 蕭培文 | |
| Research (2021) Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice more International Journal of Molecular Sciences, 2021, 22(6), 3226 |  |
| Published Papers (2020) Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis more ONCOGENE | |
| Published Papers (2020) Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer more Cancers | |
| Published Papers (2019) Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response more BIOLOGY OPEN | |
| Published Papers (2019) The mature EV71 virion induced a broadly cross-neutralizing VP1 antibody against subtypes of the EV71 virus more PLOS ONE | |
| Published Papers (2018) Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance more Autophagy | |
| Published Papers (2018) Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis more Scientific Reports | |
| Published Papers (2018) O-Glycosylation–mediated signaling circuit drives metastatic castration-resistant prostate cancer more FASEB JOURNAL | |
| Published Papers (2018) The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells more Oncogenesis | |
| Research Findings (2018) O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer more | |
| Published Papers (2017) A virus-like particle vaccination strategy expands its tolerance to H3N2 antigenic drift by enhancing neutralizing antibodies against hemagglutinin stalk more Antiviral Research | |
| Published Papers (2017) A Standardized Wedelia chinensis extract overcomes the Feedback activation of HER2/3 signaling upon androgen-ablation in prostate cancer more Frontiers in Pharmacology | |
| Published Papers (2017) A Standardized Wedelia chinensis extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer more SCIENTIFIC REPORTS | |
| Research Findings (2017) A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer more | |
| Research Findings (2017) A Standardized Wedelia chinensis Extract Overcomes the Feedback Activation of HER2/3 Signaling upon Androgen-Ablation in Prostate Cancer more | |
| Published Papers (2016) Development of single-chain variable fragments (scFv) against influenza virus targeting hemagglutinin subunit 2 (HA2) more Archives of Virology | |
| Published Papers (2016) A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses more Antiviral Research | |
| Published Papers (2016) Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis more Nature Communications | |
| Published Papers (2016) Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1 more Oncotarget | |
| Published Papers (2016) Metastatic progression of prostate cancer is mediated by autonomous binding of galectin-4-O-glycan to cancer cells more Cancer Research | |
| Research Findings (2016) Metastatic progression of prostate cancer is mediated by autonomous binding of galectin-4-O-glycans to cancer cells more | |
| Published Papers (2015) Development of a standardized and effect-optimized herbal extract of Wedelia chinensis for prostate cancer more Phytomedicine | |
| Published Papers (2015) Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis more Cancer Research | |
| Published Papers (2015) Inactivated enterovirus 71 vaccine produced by 200-l scale serum-free microcarrier bioreactor system provides cross-protective efficacy in human SCARB2 transgenic mouse more PLoS One | |
| Published Papers (2015) Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components more Molecular Cancer | |
| Published Papers (2015) Novel Cancer Therapeutics with Allosteric modulation of the mitochondrial c-Raf-DAPK complex by Raf inhibitor combination therapy more Cancer Research | |
| Published Papers (2015) Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine more PLoS One | |
| Published Papers (2015) Anticancer efficacy of unique pyridine-based tetraindoles more European journal of medicinal chemistry | |
| Published Papers (2014) Rapid and sensitive early diagnosis of influenza virus subtype via surface enhanced Raman scattering more J Biosens Bioelectron | |
| Published Papers (2014) The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family more PLoS ONE | |
| Published Papers (2014) Squalene-adjuvanted H7N9 virus vaccine induces robust humoral immune response against H7N9 and H7N7 viruses more Vaccine | |
| Published Papers (2014) HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase more ONCOGENE | |
| Published Papers (2014) Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in vitro and in vivo more Oncotarget | |
| Published Papers (2013) Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice more PLoS One | |
| Published Papers (2013) Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth and metastasis more Cancer Prevention Research | |
| Published Papers (2013) Histone demethylase retinoblastoma binding protein-2 promotes lung tumorigenesis and cancer metastasis more Cancer Research | |
| Published Papers (2012) A VLP Vaccine Induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza a virus more PLoS One | |
| Published Papers (2012) TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases more Cell Reports | |
| Honors and Awards to ABRC Scientists (2011-10) 8th, National Innovation Award (Academic Research Group, Food Category) by Institute for Biotechnology and Medicine Industry on “Wedelia chinensis extract modulates prostate cancer, benign prostatic hyperplasia (BPH) and androgen-regulated disease”. | |
| Honors and Awards to ABRC Scientists (2011-10) 8th National Innovation Award (Academic Research Group, Pharmacy Category) by Institute for Biotechnology and Medicine Industry on "Applications of Mammalian-expressed Influenza Virus-like Particles (VLPs) for Vaccine/ Antibody Manufacture and Virus Diagn | |
| Published Papers (2011) A Cullin3-KLHL20 ubiqutin ligase-dependent pathway targets PML to amplify HIF-1 signaling and tumor hypoxia responses more CANCER CELL | |
| Honors and Awards to ABRC Scientists (2010-12) The 2011 Academia Sinica Career Development Award | |
| Research (2010) Mammalian Expression of Virus-like Particles for Advanced Mimicry of Authentic Influenza Virus more PLoS ONE , 5 (3) e9784 |  |
| Published Papers (2010) Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus more PLoS One | |
| Research Findings (2010) Advanced Influenza Vaccine Technology: Mammalian Expression of Virus-like Particles Mimicking Authentic Viruses more | |
| Research (2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice more Clinical Cancer Research, 15: 5435-5444 |  |
| Published Papers (2009) Dual Degradation of Aurora A and B Kinases by the Histone Deacetylase Inhibitor LBH589 Induces G2-M Arrest and Apoptosis of Renal Cancer Cells more CLINICAL CANCER RESEARCH | |
| Published Papers (2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice more CLINICAL CANCER RESEARCH | |
| Research Findings (2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice more | |
| Research (2008) A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth in Vivo through Anti-proliferation and Pro-apoptosis more Cancer Research, 68: 6634-6642 |  |
| Published Papers (2008) A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through anti-proliferation and pro-apoptosis more Cancer Research | |
| Published Papers (2008) Crucial Role of Estrogen Receptor-α Interaction with Transcription Coregulators in Follicle-StimulatingHormone and Transforming Growth Factor β1 Up-Regulation of Steroidogenesis in Rat Ovarian Granulosa Cells more ENDOCRINOLOGY | |
| Research Findings (2008) A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth in Vivo through Anti-proliferation and Pro-apoptosis more | |
| Research (2007) Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells more Carcinogenesis |  |
| Published Papers (2007) Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFß1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells more JOURNAL OF ENDOCRINOLOGY | |
| Published Papers (2007) Critical involvement of ILK in TGFβ1-stimulated invasion/migration of human ovarian cancer cells is associated with urokinase plasminogen activator system more Experimental Cell Research | |
| Published Papers (2007) Specific plant terpenoids and Ligands Possess potent antiviral activities against severe acute respiratory syndrome coronavirus more Journal of Medicinal Chemistry | |
| Published Papers (2007) Diterpenes from Cryptomeria japonica Inhibit Androgen Receptor Transcriptional Activity in Prostate Cancer Cells more Planta Medica | |
| Published Papers (2007) Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells more CARCINOGENESIS | |
| Published Papers (2004) Early detection of antibodies against various structural proteins of the SARS-associated coronavirus in SARS patients more Journal of Biomedical Science | |
| Published Papers (2004) Characterization of two mosquito STATs, AaSTAT and CtSTAT: Differential regulation of tyrosine hosphorylation and DNA binding activity by LPS treatment and by Japanese encephalitis virus infection more Journal of Biological Chemistry | |
| Published Papers (2003) BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation more MOLECULAR AND CELLULAR BIOLOGY | |
| Published Papers (2002) Chromatin remodeling and tissue-selective responses of nuclear hormone receptors more BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | |
| Published Papers (2000) Differential regulation of testosterone vs. 5 α-dihydrotestosterone by selective androgen response elements more MOLECULAR AND CELLULAR BIOCHEMISTRY | |
| Published Papers (1999) The linkage of Kennedy's disease to Ran/ARA24, identified as the first androgen receptor poly-glutamine region associated coactivator more Journal of Biological Chemistry | |
| Published Papers (1999) Isolation and characterization of ARA160 as the first androgen receptor N-terminal associated coactivator in human prostate cells more Journal of Biological Chemistry |
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— Pei-Wen Hsiao
| Research (5) |
| Issued Patents (10) |
| Published Papers (70) |
| Research Findings (7) |
| Honors and Awards to ABRC Scientists (3) |
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