The peptide hormone RGF1 modulates PLETHORA2 stability via reactive oxygen species–dependent regulation of a cysteine residue

Our study shows that a single cysteine residue (Cys212) in the root stem cell regulator PLETHORA2 senses local hydrogen peroxide and controls the protein’s stability through S- sulfenylation, and that the peptide hormone RGF1 suppresses this modification to extend the PLT2 gradient and enlarge the root meristem.

Hsiao Y-C, Shiue S-Y, Yen M-R, Lai J-K, Yamada M. (2025) The peptide hormone RGF1 modulates PLETHORA2 stability via reactive oxygen species–dependent regulation of a cysteine residue. Plant Physiol, 2025 Jul 3;198(3):kiaf244.