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Dr. Wu has been studying glycosphingolipids for many years for the activation of an interesting immune cell type- natural killer T (NKT) cells. She has identified two lead glycolipids that are very potent in activating NKT cells and has investigated the underlying mechanisms for their superior bioactivities. The two leads have been patented and transferred to bio-industries. In addition, she also finds the interaction between NKT cells and myeloid-derived suppressor cells (MDSCs) in neuroblastoma. Since joining the ABRC, she has been investigating phyto-glycolipids and active pharmaceutical ingredients (APIs) from Chinese herbs provided by the ABRC collaborators and their interactions with dendritic cells (DCs).

Dr. Wu's research team has successfully developed assay platforms to identify bioactive subfractions from herbal extracts that activate DCs and NKT cells. Immature bone marrow-derived dendritic cells (BMDCs) were treated with doses of different subfractions. After stimulation, DCs were gated to analyze the status of DC maturation by flow cytometry. On the other hand, wild-type (WT) mouse liver mononuclear cells or splenocytes from NKT-induced pluripotent stem cell (iPSC)-derived mice were cocultured with BMDCs in the presence of APIs to study the interaction between NKT cells and API-activated DCs.