Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies

This article systematically summarizes the diversity and broad bioactivities of bacterial-derived polyyne compounds, including antibacterial, antifungal, and antiviral properties, while exploring their potential applications in biotechnology and medicine. Additionally, it provides an in-depth analysis of the structures and biosynthetic pathways of bacterial polyyne biosynthetic gene clusters (BGCs), demonstrating how core genes and tailoring enzymes work together to produce and diversify these compounds. The article also addresses the challenges of instability in polyyne production, proposing strategies such as metabolic engineering and protein engineering to optimize their stable production. Furthermore, utilizing genome mining techniques, it identifies new resources of bacterial polyyne BGCs, paving the way for the discovery of novel polyyne compounds. Finally, the article highlights the potential of bacterial polyynes in antifungal treatments, cancer therapy, and other disease management applications, emphasizing the need for further research into their toxicity and application safety, thereby laying a solid foundation for innovative applications in biotechnology and medicine.

 

同研究人員:Chin WC, Zhou YZ, Wang HY, Feng YT, Yang RY, Huang ZF