Glutathione plays a role in the cross-homeostasis between Fe and Zn
In our previous study, we found that additional iron (Fe) could increase Zn tolerance in Arabidopsis (Shanmugam et al., 2011). To understand the mechanism involved, we initiated a genetic screen. We isolated zinc tolerance induced by iron 1, designated zir1, with a defect in Fe-mediated Zn tolerance. Using map-based cloning and genetic complementation, we identify that ZIR1 encoded an enzyme involved in glutathione biosynthesis. The point mutation in ZIR1 causes the reduction of γ-ECS activity resulting in only 15% of the wild-type glutathione level in the ZIR1 mutant. This reduction of glutathione associate the Fe restoration under excess Zn. Therefore, glutathione is required for the cross-homeostasis between Zn and Fe.Kuo-Chen Yeh
Distinguished Research Fellow and Director
(02) 2787-2056
kcyeh@gate.sinica.edu.tw
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Tel: (02) 2787-2054
Director (2019.1.16-present)
Interim Director (2016.10.1 -2019.1.15)
Director/Coordinator of Molecular and Biological Agricultural Sciences program of Taiwan International Graduate Program (TIGP-MBAS), Academia Sinica (2015-2020)
Distinguished Research Fellow (2024-present)
Research Fellow (2014-2024)
Associate Research Fellow (2009-2013)
Assistant Research Fellow (2001-2009)
PDF Howard Hughes Medical Institute and Department of Biological Sciences, Stanford University, USA (1999-2001)
Ph.D. Plant Biology Graduate Group, University of California, Davis, USA (1994-1999)