Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice

Herbal remedies are the most accepted complementary and alternative medicines used among patients with prostate cancer. Plant extracts contain various compounds that have been shown to inhibit many different process of inflammation. It is intriguing that Wedelia chinensis, an ingredient of anti-inflammatory herbal medicines, also contains a set of compounds that inhibit androgen receptor signaling and in vitro growth of prostate cancer cell lines. This study examines the use of an herbal extract to treat a clinically advanced prostate cancer in animal models with castration-resistant tumors. The herbal extract restrained the prostatic tumor growth and decreased angiogenesis without observable toxicity. This preclinical study thus provides strong evidence that Wedelia chinensis is a good candidate for chemoprevention or complementary medicine.

 

同研究人員:Chin-Hsien Tsai, Feng-Min Lin, Yu-Chih Yang, Ming-Ting Lee, Tai-Lung Cha, Guan-James Wu, Shih-Chuan Hsieh, Pei-Wen Hsiao*