Cytopiloyne for preventing type 1 diabetes

Wen-Chin Yang at ABRC has identified a novel polyacetylene, cytopiloyne, from the plant Bidens pilosa in cooperation with Dr. Lie-Fen Shyur. we report that the cytopiloyne effectively prevents the development of diabetes in nonobese diabetic mice as evidenced by a normal level of blood glucose and insulin and normal pancreatic islet architecture. Cytopiloyne also suppresses the differentiation of type 1 Th cells but promotes that of type 2 Th cells, which is consistent with it enhancing GATA-3 transcription. Also, long-term application of cytopiloyne significantly decreases the level of CD4 T cells inside pancreatic lymph nodes and spleens but does not compromise total Ab responses mediated by T cells. Coculture assays imply that this decrease in CD4 T cells involves the Fas ligand/Fas pathway. Overall, our results suggest that cytopiloyne prevents type 1 diabetes mainly via T cell regulation. Chang, C.-L.-T., Chang, S.-L., Lee, Y.-M., Chiang, Y.-M., Chuang, D.-Y., Kuo, H.-K. and Yang, W.-C.* (2007). Cytopiloyne, a Polyacetylenic Glucoside, Prevents Type 1 Diabetes in Non-obese Diabetic Mice. Journal of Immunology, 178, pp. 6984-6993. Chiang, Y.-M., Chang, C.-L.-T., Chang, S.-L., Yang, W.-C.*, Shyur, L.-F.* (2006). Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. Journal of Ethnophamacology, 110(3), pp. 532-538.

 

同研究人員:Chang, C.、Chang,S.、Lee, Y.、Chiang, Y.、Chuang, D.、