Agricultural Biotechnology Research Center

Published Papers (2025-11-28) Metabolomics-Based Liquid Biopsy for Predicting Clinically Significant Prostate Cancer Cancers
Published Papers (2025-4-28) PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis Cancer Discovery
Published Papers (2025-8-29) MYADM Activates RhoA-Mediated Ameboid Migration to Drive Metastasis Cancer Research
Published Papers (2024-04-12) Development of a Novel, Potent, and Selective Sialyltransferase Inhibitor for Suppressing Cancer Metastasis International Journal of Molecular Sciences
Published Papers (2024-05-22) Predicting Clinically Significant Prostate Cancer Using Urine Metabolomics via Liquid Chromatography Mass Spectrometry The World Journal of Men's Health
Published Papers (2024-05-03) Assessment of Anti-Prostate Cancer Activity among Four Seaweeds, with Focus on Caulerpa lentillifera J.Agardh Foods
Published Papers (2024-10) Vaccine optimization for highly pathogenic avian influenza: Assessment of antibody responses and protection for virus-like particle vaccines in chickens Vaccine: X
Published Papers (2023-01-03) Immunoediting instructs tumor metabolic reprogramming to support immune evasion Cell Metabolism
Published Papers (2023-05-16) Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells eLife
Published Papers (2023-08) Pilot-scale production of inactivated monoglycosylated split H1N1 influenza virus vaccine provides cross-strain protection against influenza viruses Antiviral Research
Published Papers (2023-10-11) Prediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated study Journal of Translational Medicine
Published Papers (2022-07-06) Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression JOURNAL OF HEMATOLOGY & ONCOLOGY
Published Papers (2022-04-13) Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis ONCOGENE
Published Papers (2019) Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response BIOLOGY OPEN
Published Papers (2018) Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance Autophagy
Published Papers (2018) Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis Scientific Reports
Published Papers (2018) O-Glycosylation–mediated signaling circuit drives metastatic castration-resistant prostate cancer FASEB JOURNAL
Published Papers (2018) The extracellular SEMA domain attenuates intracellular apoptotic signaling of semaphorin 6A in lung cancer cells Oncogenesis
Published Papers (2017) A virus-like particle vaccination strategy expands its tolerance to H3N2 antigenic drift by enhancing neutralizing antibodies against hemagglutinin stalk Antiviral Research
Published Papers (2017) A Standardized Wedelia chinensis extract overcomes the Feedback activation of HER2/3 signaling upon androgen-ablation in prostate cancer Frontiers in Pharmacology
Published Papers (2017) A Standardized Wedelia chinensis extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer SCIENTIFIC REPORTS
Published Papers (2016) Development of single-chain variable fragments (scFv) against influenza virus targeting hemagglutinin subunit 2 (HA2) Archives of Virology
Published Papers (2016) A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses Antiviral Research
Published Papers (2016) Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis Nature Communications
Published Papers (2016) Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1 Oncotarget
Published Papers (2016) Metastatic progression of prostate cancer is mediated by autonomous binding of galectin-4-O-glycan to cancer cells Cancer Research
Published Papers (2015) Development of a standardized and effect-optimized herbal extract of Wedelia chinensis for prostate cancer Phytomedicine
Published Papers (2015) Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis Cancer Research
Published Papers (2015) Inactivated enterovirus 71 vaccine produced by 200-l scale serum-free microcarrier bioreactor system provides cross-protective efficacy in human SCARB2 transgenic mouse PLoS One
Published Papers (2015) Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components Molecular Cancer
Published Papers (2015) Novel Cancer Therapeutics with Allosteric modulation of the mitochondrial c-Raf-DAPK complex by Raf inhibitor combination therapy Cancer Research
Published Papers (2015) Rapamycin Promotes Mouse 4T1 Tumor Metastasis that Can Be Reversed by a Dendritic Cell-Based Vaccine PLoS One
Published Papers (2015) Anticancer efficacy of unique pyridine-based tetraindoles European journal of medicinal chemistry
Published Papers (2014) Rapid and sensitive early diagnosis of influenza virus subtype via surface enhanced Raman scattering J Biosens Bioelectron
Published Papers (2014) The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family PLoS ONE
Published Papers (2014) Squalene-adjuvanted H7N9 virus vaccine induces robust humoral immune response against H7N9 and H7N7 viruses Vaccine
Published Papers (2014) HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase ONCOGENE
Published Papers (2014) Pharmacologic Down-regulation of EZH2 Suppresses Bladder Cancer in vitro and in vivo Oncotarget
Published Papers (2013) Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice PLoS One
Published Papers (2013) Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth and metastasis Cancer Prevention Research
Published Papers (2013) Histone demethylase retinoblastoma binding protein-2 promotes lung tumorigenesis and cancer metastasis Cancer Research
Published Papers (2012) A VLP Vaccine Induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza a virus PLoS One
Published Papers (2012) TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases Cell Reports
Published Papers (2011) A Cullin3-KLHL20 ubiqutin ligase-dependent pathway targets PML to amplify HIF-1 signaling and tumor hypoxia responses CANCER CELL
Published Papers (2010) Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus PLoS One
Published Papers (2009) Dual Degradation of Aurora A and B Kinases by the Histone Deacetylase Inhibitor LBH589 Induces G2-M Arrest and Apoptosis of Renal Cancer Cells CLINICAL CANCER RESEARCH
Published Papers (2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice CLINICAL CANCER RESEARCH
Published Papers (2008) A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through anti-proliferation and pro-apoptosis Cancer Research
Published Papers (2008) Crucial Role of Estrogen Receptor-α Interaction with Transcription Coregulators in Follicle-StimulatingHormone and Transforming Growth Factor β1 Up-Regulation of Steroidogenesis in Rat Ovarian Granulosa Cells ENDOCRINOLOGY
Published Papers (2007) Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFß1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells JOURNAL OF ENDOCRINOLOGY
Published Papers (2007) Critical involvement of ILK in TGFβ1-stimulated invasion/migration of human ovarian cancer cells is associated with urokinase plasminogen activator system Experimental Cell Research
Published Papers (2007) Specific plant terpenoids and Ligands Possess potent antiviral activities against severe acute respiratory syndrome coronavirus Journal of Medicinal Chemistry
Published Papers (2007) Diterpenes from Cryptomeria japonica Inhibit Androgen Receptor Transcriptional Activity in Prostate Cancer Cells Planta Medica
Published Papers (2007) Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells CARCINOGENESIS
Published Papers (2004) Early detection of antibodies against various structural proteins of the SARS-associated coronavirus in SARS patients Journal of Biomedical Science
Published Papers (2004) Characterization of two mosquito STATs, AaSTAT and CtSTAT: Differential regulation of tyrosine hosphorylation and DNA binding activity by LPS treatment and by Japanese encephalitis virus infection Journal of Biological Chemistry
Published Papers (2003) BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation MOLECULAR AND CELLULAR BIOLOGY
Published Papers (2002) Chromatin remodeling and tissue-selective responses of nuclear hormone receptors BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
Published Papers (2000) Differential regulation of testosterone vs. 5 α-dihydrotestosterone by selective androgen response elements MOLECULAR AND CELLULAR BIOCHEMISTRY
Published Papers (1999) The linkage of Kennedy's disease to Ran/ARA24, identified as the first androgen receptor poly-glutamine region associated coactivator Journal of Biological Chemistry
Published Papers (1999) Isolation and characterization of ARA160 as the first androgen receptor N-terminal associated coactivator in human prostate cells Journal of Biological Chemistry
Published Papers (2021) Increase in Akkermansiaceae in Gut Microbiota of Prostate Cancer-Bearing Mice International Journal of Molecular Sciences
Published Papers (2021) CD28 engagement inhibits CD73-mediated regulatory activity of CD8+T cells Communications Biology
Published Papers (2021) Comparison of Chicken Immune Responses after Inoculation with H5 Avian Influenza Virus-like Particles Produced by Insect Cells or Pupae JOURNAL OF VETERINARY RESEARCH
Published Papers (2021) Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells NATURE COMMUNICATIONS
Published Papers (2021) Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and Its Derivative DETD-35 Suppress BRAF V600E Mutant Melanoma Lung Metastasis in Mice International Journal of Molecular Sciences
Published Papers (2021) Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis Journal of Medicinal Chemistry
Published Papers (2020) Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis ONCOGENE
Published Papers (2020) Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer Cancers
Published Papers (2019) The mature EV71 virion induced a broadly cross-neutralizing VP1 antibody against subtypes of the EV71 virus PLOS ONE
Research Findings (2018) O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer
Research Findings (2017) A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer
Research Findings (2017) A Standardized Wedelia chinensis Extract Overcomes the Feedback Activation of HER2/3 Signaling upon Androgen-Ablation in Prostate Cancer
Research Findings (2016) Metastatic progression of prostate cancer is mediated by autonomous binding of galectin-4-O-glycans to cancer cells
Research Findings (2010) Advanced Influenza Vaccine Technology: Mammalian Expression of Virus-like Particles Mimicking Authentic Viruses
Research Findings (2009) Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice
Research Findings (2008) A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth in Vivo through Anti-proliferation and Pro-apoptosis
Honors and Awards to ABRC Scientists (2011-10) 8th, National Innovation Award (Academic Research Group, Food Category) by Institute for Biotechnology and Medicine Industry on “Wedelia chinensis extract modulates prostate cancer, benign prostatic hyperplasia (BPH) and androgen-regulated disease”.
Honors and Awards to ABRC Scientists (2011-10) 8th National Innovation Award (Academic Research Group, Pharmacy Category) by Institute for Biotechnology and Medicine Industry on "Applications of Mammalian-expressed Influenza Virus-like Particles (VLPs) for Vaccine/ Antibody Manufacture and Virus Diagn
Honors and Awards to ABRC Scientists (2010-12) The 2011 Academia Sinica Career Development Award
Issued Patents TRANSCRIPTION MODULATOR COMPOSITIONS USA-regular US 9144591 蕭培文
Issued Patents 產生類病毒微粒之高產率轉殖基因哺乳動物表現系統 Taiwan TWI 494430 蕭培文,吳佳穎,葉怡均
Issued Patents High yield transgenic mammalian expression system for generating virus-like particles USA-regular US 8980281 蕭培文,吳佳穎,葉怡均
Issued Patents 二帖類化合物於治療攝護腺癌之用途 Taiwan TWI 434680 蕭培文,林楓閔,王升陽
Issued Patents Transcription Modulator Compositions USA-regular US8,597,701 B2 蕭培文
Issued Patents Use of diterpene,6-hydroxy-5,6-dehydrosugiol,and its derives in treatment of prostate cancer USA-regular US8519007 蕭培文,林楓閔,王升陽
Issued Patents 轉錄調控組合物 Taiwan TW I 405966 蕭培文
Issued Patents Transcription Modulator Compositions China CN 101313926B 蕭培文
Issued Patents 產生類病毒微粒之高產率轉殖基因哺乳動物表現系統 Taiwan TW I 340166 蕭培文,楊寧蓀,黃銓珍,林恩豪
Issued Patents 轉錄調控物組合物 Taiwan TW I324521 蕭培文
Research (2021) Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and its Derivative DETD-35 Suppress BRAF^V600E Mutant Melanoma Lung Metastasis in Mice International Journal of Molecular Sciences, 2021, 22(6), 3226
Seminar (2021) Exploring the Tumor Immune Microenvironment (TIME) by Tissue-Based Biomarker Measurements Dr. Nitzan Shabek (Assistant Professor, Department of Plant Biology, University of California, Davis, USA) 2021/08/09 11:00 AM Presented by Webex Meeting

Sitemap Pei-Wen Hsiao

Pei-Wen Hsiao website
Research (1)
Seminar (1)
Issued Patents (10)
Published Papers (70)
Research Findings (7)
Honors and Awards to ABRC Scientists (3)

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