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Ying-Chen Lin, Koichi Kobayashi, Chun-Hsien Hung, Hajime Wada, and Yuki Nakamura* (2016) Arabidopsis PHOSPHADYLGLCEROPHOSPHATE PHOSPHATASE1 (PGPP1) Involved in Phosphatidylglycerol Biosynthesis and Photosynthetic Function. Plant J. DOI: 10.1111/tpj.13311 http://onlinelibrary.wiley.com/doi/10.1111/tpj.13311/full


Phosphatidylglycerol (PG) is an indispensible lipid constituent of photosynthetic membrane, whose function is essential in photosynthetic activity. In higher plants, the biological function of the last step of PG biosynthesis remains elusive because an enzyme catalyzing this reaction step, namely, phosphatidylglycerophosphate phosphatase (PGPP), has been a missing piece in the entire glycerolipid metabolic map. In this study, Dr. Nakamura’s team reported AtPGPP1 encoding a PGPP in Arabidopsis thaliana. Heterologous expression of AtPGPP1 in yeast Δgep4 complemented growth defect phenotype and PG-producing activity, suggesting that AtPGPP1 encodes functional PGPP. The knockout mutant of AtPGPP1, pgpp1-1, showed pale-green phenotype with reduced PG and chlorophyll contents, defective development of chloroplast, as well as impaired photosynthetic activity. This study identified that AtPGPP1 is a primary plastidic PGPP required for PG biosynthesis and photosynthetic function in Arabidopsis.