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Yueh Cho, Chao-Yuan Yu, Yuki Nakamura and Kazue Kanehara* (2017) Arabidopsis dolichol kinase AtDOK1 is involved in flowering time control – Journal of Experimental Botany. DOI: 10.1093/jxb/erx095

Dolichols are a class of isoprenoids that play crucial roles for protein glycosylation because an oligosaccharide is assembled on a lipid carrier, dolichol diphsophate. Dr. Kazue Kanehara’s group previously identified DOLICHOL KINASE 1 (AtDOK1) that catalyzes the last step of dolichol phosphate biosynthesis in Arabidopsis [Plant J. (2015) 81, 292-303]. In this study, Dr. Kanehara group demonstrated that AtDOK1 was involved in flowing time control by use of a microRNA-mediated gene suppression technique because knockout of AtDOK1 causes lethality. Indeed, AtDOK1 was highly expressed in emerging shoot apical meristems as well as inflorescence and floral meristems as shown in the figure. Furthermore, a subcellular localization study indicated that AtDOK1 was localized at the endoplasmic reticulum (ER) in Arabidopsis. Dr. Kanehara group proposes the ER-localized catalytically active AtDOK1 is highly expressed in the meristems and possesses important roles in the control of flowering time, possibly by post-transcriptional regulations.




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