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Congratulations to Dr. Ho-Ming Chen for her promotion to Associate Research Fellow on February 2, 2018

Congratulations to Dr. Ho-Ming Chen for her promotion to Associate Research Fellow on February 2, 2018



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TCM phytochemical shikonin may be developed to serve as adjuvant for cancer vaccines

TCM phytochemical shikonin may be developed to serve as adjuvant for cancer vaccines

A research team led by Dr. Ning-Sun Yang, a former Distinguished Research Fellow (now a distinguished visiting chair) at the Agricultural Biotechnology Research Center, has recently used herbal medicine-derived shikonin (SHK) in a tumor-coculturing, dendritic cell-pulsing technology to enhance the effecicacy of a dendritic cell (DC)-based cancer vaccine.
SHK is a naphthoquinone compound that was isolated from root of traditional Chinese medicinal (TCM) herb, L. erythrorhizon. This dry root extract has been used for thousands of years in China, for treating macular eruptions, measles, sore-throat, carbuncles and burns, mainly externally, but it also can be used orally.
Dr. Yang’s team has previously demonstrated that SHK can exert anti- inflammatory activities via inhibiting the promoter activity of TNF-α and GM-CSF genes. SHK also interferes with TFN-α mRNA splicing. They further demonstrated that SK can down-regulate the expression of specific microRNAs related to epithelial-mesenchymal transition (EMT), likely resulting in expedited repair of mouse skin tissues. Most recently, they identified a protein, hnRNPA1, that can specifically bind SHK with very high affinity. Binding of SHK to hnRNPA1 was shown to affect nuclear pore transport of mRNAs and various RNA activities. This binding also was shown to result in tumor cell immunogenic cell death.
In the present study, Dr. Yang’s laboratory showed that SHK can render mouse mammary tumor cell necroptosis. SHK also activated tumor cell autophagy that in turn contributed to a sequence of events including upregulation of the ecto-form of damage-associated molecular patterns, DC activation, and augmented vaccine efficacy. Interruption of autophagic flux via chloroquine further upregulated ectoDAMP activity and resultant DC activation. Mice immunized by dying cell-pulsed DCs exerted potent efficacy in preventing mammary tumor metastasis as did the chemotherapy drug, doxorubicin (DX). Moreover, combined treatments of the SHK+DX drastically reduced the effective chemodrug dosage. These findings were published, as a Research paper-Translation entitled: Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance in the journal Autophagy on Dec. 31 in 2017. The enhanced immunogenicity and vaccine efficacy via SHK and chloroquine cotreatment of tumor cells may thus constitute a compelling strategy for developing cancer vaccines via the use of a combinational drug treatment.
The first author of the article, Sheng-Yen Lin, received his Ph.D. in the Graduate Institute of Life Science, National Defense Medical Center. Dr. Tzoong-Shoon Wu intelligently and diligently helped direct this research approach. This work was supported by the grant from Ministry of Science and Technology of Taiwan and an Investigator Award by Academia Sinica.


Figure(A) The research team: Mr. Lin Sheng-Yen, Ph. D. student at the Graduate Institute of Life Sciences of National Defense Medical Center; Dr. Ning-Sun Yang, Distinguished Research Fellow, ABRC; Dr. Tzoong-Shoon Wu, Visiting scholar, IMB.
Figure(B) The research team's findings support the promising application of phytochemical shikonin on dendritic cell-based cancer vaccine for anti-tumor metastasis activity.


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ABRC Assistant Research Fellow Dr. Ho-Ming Chen awarded the 2017 Ta-You Wu Memorial Award

ABRC Assistant Research Fellow Dr. Ho-Ming Chen awarded the 2017 Ta-You Wu Memorial Award

Assistant Research Fellow Dr. Ho-Ming Chen is among the recipients of the 2017 Ta-You Wu Memorial Award, the Ministry of Science and Technology (MOST) announced recently.

The Ta-You Wu Memorial Award, established by MOST, commemorates the contribution of atomic and nuclear theoretical physicist Dr. Ta-You Wu to the development of science and technology research. It aims to nurture young and upcoming researchers by providing each recipient with a one-time cash prize.

Dr. Chen's research focuses on understanding how plants use small RNAs to regulate gene expression by integrating next-generation sequencing and bioinformatics.

Previously Director Kuo-Chen Yeh (2002), Research Fellow Ming-Tsair Chan (2004), and Assistant Research Fellow Yu-Liang Yang (2016) of ABRC all received the award.

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Congratulations to Dr. Ho-Ming Chen on winning the 2017 Shang-Fa Yang Young Scientist Award!

Congratulations to Dr. Ho-Ming Chen on winning the 2017 Shang-Fa Yang Young Scientist Award!

Assistant Research Fellow Dr. Ho-ming Chen was awarded the "Academician Shang-Fa Yang Award for Outstanding Young Scholars in the Agricultural Sciences” at the "10th Shang-Fa Yang Memorial Lecture" at Academia Sinica on 30 October, 2017. During the seminar, which was sponsored by the Shang-Fa Yang Memorial Foundation, Dr. Chen was awarded a medal and presented her research results in a lecture entitled "Shedding light on the plant small RNA world with NGS data and bioinformatics."

The Shang-Fa Yang Memorial Foundation was established to honor the distinguished career of late Academician Yang and one of its roles is the cultivation of young researchers. The "Academician Shang-Fa Yang Award for Outstanding Young Scholars in the Agricultural Sciences" was established to recognize the potential for academic innovation and important industrial contribution by young domestic scholars. This year the 10th Shang-Fa Yang Memorial Lecture was held over two days on 30 and 31 October 2017 at Academia Sinica and the Academia Sinica Biotechnology Center in Southern Taiwan.

Dr. Chen's research focuses on understanding how plants use small RNAs to regulate gene expression by integrating next-generation sequencing and bioinformatics.


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Dr. Shyur presents President of Uruguay with leadership award on behalf of breast cancer society

Dr. Shyur presents President of Uruguay with leadership award on behalf of breast cancer society

The ABRC's Dr. Lie-Fen Shyur visited Uruguay on October 26, to help present the President of Uruguay, Dr. Tabaré Vázquez, with the Susan Bulkeley Butler Leadership Excellence Award on behalf of International Breast Cancer and Nutrition (IBCN) collaboration. Dr. Shyur is an Executive Committee member and also the leader/coordinator of Taiwan chapter of the IBCN and she presented the award along with the other IBCN executive members.

President Vázquez is a radiation oncologist who has taught radiology and pushed for health reforms including bans on public smoking in his country for decades. He was recognized by the award for his long-term support and contribution to fighting life threatening cancers. The presidency link with the news about the award to President Vazquez. https://www.presidencia.gub.uy/comunicacion/comunicacionnoticias/vazquez-premio-galardon-reconocimiento-cancer

Following on from the award ceremony the group attended The Seventh International Breast Cancer Prevention Symposium entitled “Creating Resources for Research and Interventions” in Montevideo, Uruguay from October 31 to November 1, 2017. The event was co-organized by the University of Montevideo, Purdue University Center for Cancer Research and the IBCN headquarters. The IBCN is headquartered at Purdue University, USA.

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Congratulations to the 2017 Travel Grant Award Winners!!

Congratulations to the 2017 Travel Grant Award Winners!!



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Congratulations to the 2017 Outstanding Presentation Award Winners!!

Congratulations to the 2017 Outstanding Presentation Award Winners!!



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Congratulations to the 2017 Outstanding Poster Award Winners!!

Congratulations to the 2017 Outstanding Poster Award Winners!!



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Congratulation to Mr. Chung-Chih Yang, a PhD student from Dr. Lei-Fen ShyurHong-yen Hsu 100th Anniversary Special Award” of the “32th international symposium on natural product” on October 13th-14th, 2017.'>

Congratulation to Mr. Chung-Chih Yang, a PhD student from Dr. Lei-Fen Shyur's laboratory, who received the“Hong-yen Hsu 100th Anniversary Special Award” of the “32th international symposium on natural product” on October 13th-14th, 2017.



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Congratulation to Mr. Pei-Min Yeh and Mr. Cheng-Han Hsieh from Dr. Lie-Fen Shyur laboratory for receiving the “<b>Sliver Award</b>” in the poster competition of “The 13<sup>th</sup> International Symposium on Biocatalysis and Agricultural Biotechnology”(ISBAB) on Oct 17<sup>th</sup>-20<sup>th</sup>, 2017.

Congratulation to Mr. Pei-Min Yeh and Mr. Cheng-Han Hsieh from Dr. Lie-Fen Shyur laboratory for receiving the “Sliver Award” in the poster competition of “The 13th International Symposium on Biocatalysis and Agricultural Biotechnology”(ISBAB) on Oct 17th-20th, 2017.



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*2018/03/05 10:30 AM
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