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演講訊息

中藥的自然資源與文化資源

Conference RM 133, Agricultural Technology Building
2010/01/11 16:00 ~ 18:00 pm
Prof. Zhongzhen Zhao (Professor, Course Director-BPharm, School of Chinese Medicine, Hong Kong Baptist University)
Host: Ning-Sun Yang


In Vitro Pharmacokinetic Screens Using Caco-2 Cell and Liver Microsome for the Prediction of Oral Bioavailability

Conference RM 133, Agricultural Technology Building
2010/01/25 16:00 ~ 18:00 pm
Dr. Chia-Chung Hou (Assistant Specialist, Agricultural Biotechnology Research Center, Academia Sinica)
Host: Tzyy-Jen Chiou


Emerging Strategies of Delignification for Converting Lignocellulosics into Bioethanol

Conference RM 133, Agricultural Technology Building
2010/02/01 16:00 ~ 18:00 pm
Dr. Lie-Fen Shyur (Research Fellow and Vice Director, Agricultural Biotechnology Research Center, Academia Sinica)
Host: Pei-Wen Hsiao


Immunomodulatory Activities of Dietary Polysaccharides: Roles of Structure and Molecular Property

Conference RM A133, Agricultural Technology Building
2010/02/26 14:00 ~ 15:00 pm
Dr. Phoency Lai (Professor, Department of Food and Nutrition, Providence University) (Cancel)
Host: Ning-Sun Yang


Boron transporters; regulation of expression and coordination for efficient transport

Conference RM A134, Agricultural Technology Building
2010/03/08 16:00 ~ 18:00 pm
Dr. Toru Fujiwara (Associate Professor, Biotechnology Research Center, The University of Tokyo, Japan)
Host: Tzyy-Jen Chiou
Boron was established as an essential element for plants more than 85 years ago. For a long time, boron transport was considered to be a passive process. Boron is present mostly as boric acid, a charge neutral molecule, in neutral pH solution and this membrane permeability is several orders of magnitude higher than ions. It has long been believed that passive diffusion through lipid bilayers is sufficient to fulfill plant needs for boron.
In the last several years, with the use of molecular genetics of Arabidopsis and rice, transporters responsible for boron transport have been identified. Two types of transporters, BORs and NIPs are required for boron uptake, xylem loading, distribution among leaves, efflux from roots. Through the characterization of these transporters, it is now revealed that plants regulate these transporters in response to the boron conditions in the environment. Further more, with the use of the knowledge of the transport systems, plants tolerant to low- or high-boron stress have been generated. These technologies may be useful to design plants/crops tolerant to soils with low or high boron in the future.


Role of ETS-gene alterations in the development of human prostate cancer

Conference RM A134, Agricultural Technology Building
2010/03/15 16:00 ~ 18:00 pm
Prof. Collin S Cooper (Professor, The Institute of Cancer Research: Royal Cancer Hospital, UK.)
Host: Pei-Wen Hsiao


Cellular senescence and cell cycle control by Jun dimerization protein JDP2

Conference RM A133, Agricultural Technology Building
2010/03/29 16:00 ~ 18:00 pm
Prof. Kazunari K. Yokoyama (Professor, Graduate Institute of Medicine, Kaohsiung Medical University)
Host: Wen-Chin Yang
Jun dimerization protein 2 [JDP2, AP-1 transcription factor] is involved in the regulation of the differentiation and proliferation of cells. We report here that JDP2-deficient mouse embryonic fibroblasts (Jdp2-/- MEF) are resistant to replicative senescence. In the absence of JDP2, the level of expression of p16Ink4a, which is known to rise as normal fibroblasts age, fell significantly when cells were cultured for more than two months. Conversely, the overexpression of JDP2 induced the expression of genes for p16Ink4a and p19Arf. Moreover, at the promoter of the gene for p16Ink4a in Jdp2-/- MEF, the extent of methylation of lysine 27 of histone H3 (H3K27), which is important for gene silencing, is increased. Polycomb repressive complexes (PRC-1 and PRC-2), which are responsible for histone methylation, bound efficiently to the promoter to repress the expression of the gene for p16Ink4a. As a result, JDP2-deficient MEF became resistant to replicative senescence. Our results indicate that JDP2 is involved in the signaling pathway for senescence via epigenetic regulation of the expression of the gene for p16Ink4a. We also found a novel role for JDP2 as a regulator of the progression of normal cells through the cell cycle. The healing of wounded skin of Jdp2KO mice proceeded more rapidly than that of control mice and more proliferating cells were found at wound margins. Fibroblasts derived from embryos of Jdp2KO mice proliferated more rapidly and formed more colonies than wild-type fibroblasts. JDP2 was recruited to the promoter of the gene for cyclin A2 (ccna2) at a previously unidentified AP-1 site. Cells lacking Jdp2 had elevated levels of cyclin A2 mRNA. Moreover, reintroduction of JDP2 resulted in repression of transcription of ccna2 and of cell cycle progression. Thus, transcription of the gene for cyclin A2 appears to be a direct target of JDP2 in the suppression of cell proliferation. These studies indicate that the JDP2 plays a role of the cell cycle arrest and the replicative senescence.


Workshop on applications of high throughput DNA sequencing

Genome analysis of complex samples, from crops to metagenomics

Diversity genomics across the Brassicaceae

Auditorium A134, Agricultural Technology Building
2010/04/08 14:00 ~ 17:00 pm
Dr. Dave Edwards & Dr. Jacqueline Batley (University of Queensland)
Host:


Establishing mouse models for inheritant kidney diseases

Conference RM A133, Agricultural Technology Building
2010/04/12 16:00 ~ 18:00 pm
Dr. Si-Tse Jiang (Associate Scientist, National Laboratory Animal Center, National Applied Research Laboratories)
Host: Wen-Chin Yang


The Sterile Inflammatory Response to Necrotic Cell Death

Conference RM A133, Agricultural Technology Building
2010/05/03 16:00 ~ 18:00 pm
Dr. Chun-Jen Chen (Assistant Professor, Department of Biochemical Science and Technology, National Taiwan University)
Host: Wen-Chin Yang


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