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演講訊息

TBA

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/01 10:00 AM
Dr. K. J. Senthil Kumar (Post-Doctoral Fellow, Department of Forestry, National Chung Hsing University, Taiwan)
Host: Lie-Fen Shyur


Environmental Epigenetics for the Primary Prevention of Cancer

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/07 10:30 AM
Dr. Sophie A. Lelièvre (Professor of Basic Medical Sciences with courtesy appointment in Nutrition Science; coleader, Drug Discovery & Molecular Sensing NCI-designated Purdue Center for Cancer Research; Scientific Director, 3D Cell Culture Core (3D3C) Facility, Birck Nanotechnology Center, Discovery Park, Purdue University, USA)
Host: Lie-Fen Shyur
In order to understand how to reduce the risk for chronic diseases related to metabolic changes like cancers, we need to decipher how environmental detrimental factors such as pollutants and high fat/high sugar dietary components modify the cells and their microenvironment. Similarly, the search for bioactive compounds from medicinal plants and fungi that would help decrease cancer risk requires the study of their impact on mechanisms of cancer onset. The chemical modifications on DNA and histones constitute the epigenome that, at any given time, controls gene expression. Since cancer onset is fundamentally linked to an altered epigenome, it is essential that the investigations of deleterious and protective environmental factors focus on epigenetic pathways. I will present how organs-on-a-chip, the state-of-the-art in vitro models prepared with humans cells, play a central role in this endeavor and might provide population-specific answers regarding how to modulate cancer risk. Oxidative stress, a paramount mediator of cancer related to pollution, psychological stress and unhealthy diet will be used as an example of how we can build a multi-organs-on-a-chip screening system.


Biosensors and what we do NOT know about crop yield

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/08 4:00 PM
Prof. Dr. Wolf B. Frommer (Alexander von Humboldt Professor, Heinrich Heine University Düsseldorf/ Max Planck Institute for Plant Breeding Research, Cologne, Germany)
Host: Cheng-Hsun Ho
In the first part, I will summarize some of the recent findings regarding the path of sugar from leaves to seeds. I will highlight the immense lack of knowledge in this particular field. Then I will switch to potential ways that may contribute to a better understanding of these processes.
Does grinding up a brain and measuring neurotransmitter levels by mass spectrometry help to understand the concepts of memory? Does analysis of the leaf sugar content tell us something about what determines crop yield? I propose that in order to understand complex phenomena like these, we need to know more, in particular about the where and when, with exquisite resolution. Where is the sugar? Does it actually move through plasmodesmata? What are the levels in which cell, in which compartment and how much is outside. What happens of we transiently block a step – what can we learn from the properties of the resulting traffic jam. Thus one tool we will need is something to transiently block a protein in a surgical manner. And we need to be able to measure the precise spatial and temporal dynamics of small molecules such as sugars as well as the in vivo activity of the participating enzymes and transporters as well as their regulators. The late Roger Tsien invented new concepts: the quantification of protein conformational rearrangements as proxies for analyte levels. He developed two principal sets of sensors: Förster resonance energy transfer sensors (which may not deserve the name) and conformation-sensitive single fluorophore sensors based on circularly permutated fluorescent proteins. My lab only expanded the tool set in two directions – for measuring small molecules such as sugars, amino acids, hormones and more recently as tools for reporting the activity of proteins – here transporters in vivo.


TBA

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/14 10:30 AM
Dr. Hsin Ling Hsu (Associate Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan)
Host: Wen-Chin Yang


TBA

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/28 10:30 AM
Dr. Shuang Wu (Professor, Fujian Agriculture and Forestry University,
China)
Host: Tzyy-Jen Chiou


  

2018 SEMINAR

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