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演講訊息

A Voyage on the Sea of Phytomedical Research

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/01 10:00 AM
Dr. K. J. Senthil Kumar (Post-Doctoral Fellow, Department of Forestry, National Chung Hsing University, Taiwan)
Host: Lie-Fen Shyur


Biosensors and what we do NOT know about crop yield

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/08 4:00 PM
Prof. Dr. Wolf B. Frommer (Alexander von Humboldt Professor, Heinrich Heine University Düsseldorf/ Max Planck Institute for Plant Breeding Research, Cologne, Germany)
Host: Cheng-Hsun Ho
In the first part, I will summarize some of the recent findings regarding the path of sugar from leaves to seeds. I will highlight the immense lack of knowledge in this particular field. Then I will switch to potential ways that may contribute to a better understanding of these processes.
Does grinding up a brain and measuring neurotransmitter levels by mass spectrometry help to understand the concepts of memory? Does analysis of the leaf sugar content tell us something about what determines crop yield? I propose that in order to understand complex phenomena like these, we need to know more, in particular about the where and when, with exquisite resolution. Where is the sugar? Does it actually move through plasmodesmata? What are the levels in which cell, in which compartment and how much is outside. What happens of we transiently block a step – what can we learn from the properties of the resulting traffic jam. Thus one tool we will need is something to transiently block a protein in a surgical manner. And we need to be able to measure the precise spatial and temporal dynamics of small molecules such as sugars as well as the in vivo activity of the participating enzymes and transporters as well as their regulators. The late Roger Tsien invented new concepts: the quantification of protein conformational rearrangements as proxies for analyte levels. He developed two principal sets of sensors: Förster resonance energy transfer sensors (which may not deserve the name) and conformation-sensitive single fluorophore sensors based on circularly permutated fluorescent proteins. My lab only expanded the tool set in two directions – for measuring small molecules such as sugars, amino acids, hormones and more recently as tools for reporting the activity of proteins – here transporters in vivo.


Targeting oncogene MCT-1 prevents tumor progression and alters microenvironment

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/14 10:30 AM
Dr. Hsin Ling Hsu (Associate Investigator, Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan)
Host: Wen-Chin Yang


The immune modulators derived from nordihydroguaiaretic acid increase the humoral immunity against tumor

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/22 10:00 AM
Dr. Yu-Lin Ling (Assistant Research Fellow, Center for Bioinformatics Research, Department of Biological Science and Technology, National Chiao Tung University, Taiwan)
Host: Lie-Fen Shyur


Regulatory network behind endodermal differentiation in plants

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/05/28 10:30 AM
Dr. Shuang Wu (Professor, Horticultural Plant Biology and Metabolomics Center, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, China)
Host: Tzyy-Jen Chiou
The development of multicellular organisms requires precise control of cellular differentiation. The endodermis in plant roots is of fundamental importance for water and nutrient uptake, and is also an excellent model for studying developmental regulation of differentiation. Specified in the meristem, endodermis undergoes successive terminal differentiations, marked by the formation of Casparian strips and suberin lamellae. Although the endodermal initiation in meristem was shown to be controlled by SHORT-ROOT (SHR) mediated pathway, the mechanism promoting endodermal differentiation remains unknown. Here we examined the minimal regulators required for programing endodermal differentiation. Our results reveal that SHR serves as the master regulator of the hierarchical signaling cascades during endodermal maturation. We further analyzed the complex network downstream of SHR and provided the mechanistic insight into the function of SHR mediated pathway. Our study is a demonstration of the deployment of symplastic communications in the promotion of a specific cell fate.


  

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