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演講訊息

Rice-based vaccine “MucoRice” as a novel oral vaccination system

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2017/03/27 10:30 AM
Dr. Hiroshi Kiyono (Professor and Director, Division of Mucosal Immunology, Department of Microbiology and Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo (IMSUT), Japan)
Host: Shu-Mei Liang
The intestine is continuously exposed to outside environment and thus faced the threating from the invasion of gut pathogens. The digestive tract is thus furnished with the mucosal immune system (MIS) offering the first line of defense against invasion of pathogens. To combat gut pathogen-induced diarrhea often causes a life-threatening situation in the developing countries, the fusion science among mucosal immunology, agriculture science and plant factory engineering created a new strategy for the development of rice-based oral vaccine “MucoRice” as a new generation of refrigeration and needle/syringe free vaccine. Oral administration of MucoRice expressing B subunit of cholera toxin (MucoRice-CTB) induced antigen-specific secretory IgA antibody-mediated protective immunity against Vibrio cholera-induced diarrhea. The MucoRice system has been extended to construct MucoRice expressing a rotavirus-specific neutralizing nanoantibody, ARP1. Orally administered MucoRice-ARP1 decreased the severity of rotavirus-induced diarrhea. The MucoRice system is thus offering new and novel strategy for the prevention and control of infectious diseases.


  

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