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演講訊息

Impact of Selected Sugar Transporters on Plant Properties

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/01/12 10:30 AM
Dr. Ekkehard Neuhaus (Professor (Chair), Department of Biology, Plant Physiology, University of Kaiserslautern, Germany)
Host: Tzyy-Jen Chiou


Agriculture Bioeconomy of Taiwan

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/01/15 10:30 AM
Dr. Huu-Sheng Lur (College of Bioresources of Agriculture, National Taiwan University, Taiwan)
Host: Lie-Fen Shyur


CRISPR Genome Editing in Outcrossing Species: from knockout to allelic series mutagenesis (and dose-dependent tradeoffs of lignin reduction)

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/01/22 10:30 AM
Dr. Chung-Jui Tsai (Haynes Professor and Eminent Scholar, School of Forestry and Natural Resources, Department of Genetics, Department of Plant Biology, University of Georgia, USA)
Host: Kuo-Chen Yeh


Taming and hunting retrotransposons in plants

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/02/05 10:00 AM
Dr. Jungnam Cho (Postdoctoral Research Associate, The Sainsbury Laboratory, University of Cambridge, UK)
Host: Ho-Ming Chen


Dissecting the Epigenomics of Seed Development

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/02/07 10:00 AM
Dr. Jer-Young Lin (Assistant Project Scientist, Department of Molecular, Cell, & Developmental Biology, University of California, Los Angeles (UCLA))
Host: Tzyy-Jen Chiou


Development of new cytokinin derivatives for plant biotechnology: from synthesis to analysis and back again

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/03/05 10:30 AM
Dr. Karel Doležal (Senior Researcher, Head of Chemical Biology and Genetics Department, Centre of the Region Haná for Biotechnological and Agricultural Research, the Czech Republic)
Host: Su-Chiung Fang
Cytokinins (CK) are an important class of plant hormones, organic substances naturally occurring at extremely low concentrations, which regulate major physiological processes in plants.
6-Benzylaminopurine (BAP), an important and affordable cytokinin, is routinely utilized in micropropagation for its effective stimulatory properties. However, this compound and/or its endogenous metabolites may negatively influence the shoot proliferation, rooting and acclimatization processes in some plant species (Werbrouck et al., 1996; Strnad, 1997). Therefore, the development of other new CK derivatives exhibiting high morphogenetic activity might consequently be of a great practical importance in plant biotechnology. Based on our search for naturally occurring aromatic cytokinins in plants, we recently synthesized several new groups of their analogues having high activity in different CK bioassays as well as the ability to activate cytokinin receptors and/or to inhibit CKX. The best compounds have been tested as a new tool for retardation of senescence during the multiplication stage of micropropagation of selected plant species as well as to support rooting and acclimatization competence. Subsequently, wide range of endogenous plant hormones and their metabolites were quantified during these experiments and compared in relation to cytokinin exogenously used as well as micropropagation efficiency. Results of these measurements have been used to design second generation of 9-substituted CK derivatives with improved metabolic properties.

Research was supported by the Ministry of Education Youth and Sports, Czech Republic
(grant LO1204 from the National Program of Sustainability and Agricultural Research).


Biochemical and Functional Characterization of Seed Coat Mucilage

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/03/12 10:00 AM
Dr. Allen Yi-Lun Tsai (Post-doctoral Fellow, Graduate School of Science and Technology, Kumamoto University, Japan)
Host: Hsin-Hung Yeh


Function of alternatively spliced isoforms and a small peptide in root development

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/03/19 10:00 AM
Dr. Masashi Yamada (Postdoctoral Fellow, Duke University, U.S.A.)
Host: Yet-Ran Chen


Rational design of site-specific glycan-masking and glycan-unmasking HA antigens as new-generation influenza vaccines

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/04/09 10:30 AM
Dr. Suh-Chin Wu (Professor, Institute of Biotechnology, National Tsing Hua University, Taiwan)
Host: Shu-Mei Liang


A Transcriptome Based Approach To The Identification Of Candidate Molecular Mechanisms In Traditional Chinese Medicine

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center
2018/04/16 10:30 AM
Dr. David Adelson (Professor and Chair of Bioinformatics and Computational Genetics, School of Molecular and Biomedical Science, The University of Adelaide, Australia)
Host: Wen-Chin Yang
Background:
There is little evidence based medicine supporting TCM, particularly with respect to potential molecular modes of action of TCM preparations. Because TCM preparations are often combinations of multiple herbs containing hundreds of compounds, they have been difficult to study. Compound Kushen Injection (CKI) is one such complex mixture and has been in use in hospitals in China for over twenty years for the integrated treatment of cancer. The development of high throughput -omics methods has allowed better characterization of TCM, and we have previously identified many differentially expressed genes regulated by CKI in a breast cancer cell line.
Methods:
We have applied high-throughput transcriptome data in two additional cancer cell lines and integrated our differential expression results across cell lines to identify a reduced set of differentially expressed (DE) candidate genes as well as a reproducible set of candidate pathways that are perturbed by CKI.
Results:
CKI induced cell-cycle arrest and apoptosis. We identified 363 core candidate genes that were associated with cell cycle, apoptosis, DNA replication/repair and various cancer pathways. Of these, 7 are known to be clinically relevant to cancer diagnosis or therapy and 14 are cell cycle regulators, and most of these 21 candidates are downregulated by CKI. Comparison of our core candidate genes to a database of plant medicinal compounds and their effects on gene expression identified one-to-one, one-to-many and many-to-many regulatory relationships between compounds in CKI and DE genes.

Conclusion:
By identifying a number of promising candidate pathways and genes associated with CKI based on our transcriptome based analysis, we have shown this type of approach is useful for the systematic analysis of molecular changes resulting from complex mixtures of bioactives in the context of cancer therapy.


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