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S. Kailasam, S. Singh, M.-J. Liu, C.-C. Lin and K.-C. Yeh* (2020) A HemK class glutamine-methyltransferase is involved in the termination of translation and essential for iron homeostasis in Arabidopsis. New Phytologist doi.org/10.1111/nph.16440


Fe-deficiency induced transcriptional cascades controls Fe transport and utilization is important for plant to maintain homeostasis of this important element executing the biological function. So far, we know that many genes participating in these processes are transcriptionally controlled by Fe-status. By a genetical approach, we identified a novel component, HemK-like methyltransferase, that is involved in the termination of translation. With defect of this gene, plants lose ion homeostasis and are highly sensitive to Fe deficiency and possess other developmental flaws. We detected that many Fe-deficiency-inducible transcripts exhibit ribosome stalling implying translational failings in the mutant. In this study, a check-point that fine tunes the peptide release for growth and development in plants is uncovered. Our report sheds light on mechanisms of translation termination and its importance in preserving both molecular and physiological responses to Fe-starvation.

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*2020/11/09 11:00 AM
戴廷恩博士 (行政院農業委員會農業試驗所花卉研究中心 研究員兼主任)
蝴蝶蘭產業概況及研究規劃
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