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Sakthivel Kailasam, Ying Wang, Jing-Chi Lo, Hsin-Fang Chang and Kuo-Chen Yeh* (2018) S-nitrosoglutathione works downstream of nitric oxide to mediate iron deficiency signaling in Arabidopsis The Plant Journal, DOI: 10.1111/tpj.13850


Several studies elucidated the transcriptional responses to iron (Fe) starvation, however, the Fe sensing and signal transduction machineries are poorly resolved thus far in plants. With this focus, by using chemical biology approach, we identified a small molecule R7, whose use inhibited the physiological and molecular responses of Fe starvation in Arabidopsis. R7 blocked the Fe starvation signaling from nitric oxide (NO) to the central transcription factor, FER-LIKE IRON-DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT). Exogenous applications of NO abduct, S-nitrosoglutathione (GSNO) were able to attenuate the R7 effect. R7 directly or indirectly decreased the endogenous GSNO levels in roots but not the NO levels. Our finding reveals that, under Fe limited situation the starvation signal from NO is passed to FIT through GSNO.
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*2018/08/13 10:30 AM
Dr. Yea-Lih Lin (Researcher, Institute of Human Genetics, CNRS, France)
SAMHD1 acts at stalled replication forks to prevent interferon induction
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

*2018/08/22 10:30 AM
Dr. Nathaniel Robert Street (Associate Professor, Department of Plant Physiology, Umeå University, Sweden)
Systems genetics and genomics insights into complex traits in aspen and Norway spruce
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

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