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Kuo, H.-F., Hsu, Y.-Y., Lin, W.-C., Chen, K.-Y., Munnik, T., Brearley, C. A.* and Chiou, T.-J.* (2018) Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis. The Plant J. (doi:10.1111/tpj.13974)
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to mediate Pi signaling remains unknown. Here, using genetics and InsP profiling combined with Pi starvation response (PSR) analysis in Arabidopsis thaliana, we showed that the kinase activity of inositol pentakisphosphate 2-kinase (IPK1), an enzyme required for phytate (inositol hexakisphosphates; InsP6) synthesis, is indispensable for maintaining Pi homeostasis under Pi-replete conditions, and inositol 1,3,4-trisphosphate 5/6-kinase 1 (ITPK1) plays an equivalent role. Although both ipk1-1 and itpk1 mutants exhibited decreased levels of InsP6 and diphosphoinositol pentakisphosphate (PP-InsP5; InsP7), disruption of another ITPK family enzyme, ITPK4, which correspondingly caused depletion of InsP6 and InsP7, did not display similar Pi-related phenotypes, which precludes these InsP species as effectors. Notably, the level of D/L-Ins(3,4,5,6) P4 was concurrently elevated in both ipk1-1 and itpk1 mutants, which showed a specific correlation to the misregulated Pi phenotypes. However, the level of D/L-Ins(3,4,5,6)P4 is not responsive to Pi starvation that instead manifests a shoot-specific increase in InsP7 level. This study demonstrates a more nuanced picture of the intersection of InsP metabolism and Pi homeostasis and PSR than has previously been elaborated and additionally establishes intermediate steps to phytate biosynthesis in plant vegetative tissues. link

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Research Fellow Kuo-Chen Yeh appointed Director of the Agricultural Biotechnology Research Center

2018/10/29 ABRC Seminar 2018/10/18 ABRC Seminar The ABRC 19th Annual Poster Competition 2018

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*2019/02/25 10:30 AM
Dr. Juine-Ruey Chen (RuenHuei Biopharmaceuticals. Inc.)
我的生技旅程: 感染症疫苗開發
Auditorium A134, Agricultural Technology Building, Academia Sinica

*2019/03/04 10:30 AM
Dr. Guido Grossmann (Group Leader, the Centre for Organismal Studies (COS) Heidelberg, Heidelberg University, Germany)
TBA
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

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Lin W-Y, Lin Y-Y, Chiang S-F, Syu C, Hsieh L-C*, Chiou T-J* (2018) Evolution of microRNA827 targeting in the plant kingdom. New Phytologist 217: 1712-1725

Leong, S. J., Lu, W.-C. and Chiou, T.-J.* (2018) Phosphite-Mediated Suppression of Anthocyanin Accumulation Regulated by Mitochondrial ATP Synthesis and Sugar in Arabidopsis. Plant & Cell Physiology 59: 1158-1169

Hsiang-chin Liu†, Jörn Lämke†, Siou-ying Lin†, Meng-Ju Hung, Kuan-Ming Liu, Yee-yung Charng*, Isabel Bäurle* (2018) Distinct heat shock factors and chromatin modifications mediate the organ-autonomous transcriptional memory of heat stress. Plant J. https://doi.org/10.1111/tpj.13958

Lin, Y.-C., Wang, J., Delhomme, N., Schiffthaler, B., Sundström, G., Zuccolo, A., Nystedt, B., Hvidsten, T. R., de la Torre, A., Cossu, R. M., Hoeppner, M. P., Lantz, H., Scofield, D. G., Zamani, N., Johansson, A., Mannapperuma, C., Robinson, K. M., Mähler, N., Leitch, I. J., Pellicer, J., Park, E.-J., Van Montagu, M., Van de Peer, Y., Grabherr, M., Jansson, S., Ingvarsson, P. K. and Street, N. R. (2018) Functional and evolutionary genomic inferences in Populus through genome and population sequencing of American and European aspen. PNAS published ahead of print October 29, 2018

Chung-Chih Yang, Cheng-Kuei Chang, Meng-Ting Chang, and Lie-Fen Shyur*(2018) Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-α-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice. International Journal of Cancer,2018, 15;143(12):3248-3261. doi: 10.1002/ijc.31663.

Unlike most ancient microRNAs, which conservatively target homologous genes across species, microRNA827 (miR827) targets two different types of SPX (SYG1/PHO81/XPR1)-domain-containing genes, NITROGEN LIMITATION ADAPTATION (NLA) and PHOSPHATE TRANSPORTER 5 (PHT5), in Arabidopsis thaliana and Oryza sativa to regulate phosphate (Pi) transport and storage, respectively. ...more
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