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Kyoko Nakagawa-Goto*, Jo-Yu Chen, Yu-Ting Cheng, Wai-Leng Lee, Munehisa Takeya, Yohei Saito, Kuo-Hsiung Lee*, and Lie-Fen Shyur* (2016) Novel sesquiterpene lactone analogues as potent anti-breast cancer agents. Molecular Oncology, 2016, 10(6):921-937
Triple-negative breast cancer (TNBC) is associated with high grade, metastatic phenotype, younger patient age, and poor prognosis. The discovery of an effective anti-TNBC agent has been a challenge in oncology. In this study, fifty-eight ester derivatives (DETDs) with a novel sesquiterpene dilactone skeleton were organically synthesized from a bioactive natural product deoxyelephantopin (DET). Among them, DETD-35 showed potent antiproliferative activities against a panel of breast cancer cell lines including TNBC cell line MDA-MB-231, without inhibiting normal mammary cells M10. DETD-35 exhibited a better effect than parental DET on inhibiting migration, invasion, and motility of MDA-MB-231 cells in a concentration-dependent manner. Comparative study of DETD-35, DET and chemotherapeutic drug paclitaxel (PTX) showed that PTX mainly caused a typical time-dependent G2/M cell-cycle arrest, while DETD-35 or DET treatment induced cell apoptosis. In vivo efficacy of DETD-35 was evaluated using a lung metastatic MDA-MB-231 xenograft mouse model. DETD-35 significantly suppressed metastatic pulmonary foci information along with the expression level of VEGF and COX-2 in SCID mice. DETD-35 also showed a synergistic antitumor effect with PTX in vitro and in vivo. This study suggests that the novel compound DETD-35 may have a potential to be further developed into a therapeutic or adjuvant agent for chemotherapy against metastatic TNBC. link

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*2017/05/15 10:30 AM
Dr.Josef Komenda (Senior scientist and head of the Laboratory of photosynthesis, Department of phototrophic microorganisms - Algatech, Institute of Microbiology, Academy of Sciences, Třeboň, Czech Republic)
Making the cyanobacterial Photosystem II from scratch
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

*2017/06/05 10:30 AM
Dr. Hsin-Chih Lai (Chair and Professor, Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan)
Traditional Chinese herbs, gut microbiome and obesity
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

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H.-F. Chang, S.-L. Wang and K.-C. Yeh* (2017) Effect of gallium exposure in Arabidopsis thaliana is similar to aluminum stress. Environmental Science & Technology: Accepted DOI: 10.1021/acs.est.6b05760

Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, and Lie-Fen Shyur* (2016) A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice. Molecular Cancer Therapeutics, 15(6):1163-1176

Maria Karmella Apaya, Meng-Ting Chang, and Lie-Fen Shyur* (2016) Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics.Pharmacology & Therapeutics 162:58-68

Ya-Ting Chao, Shao-Hua Yen, Jen-Hau Yeh, Wan-Chieh Chen, Ming-Che Shih*(2017) Orchidstra 2.0—A Transcriptomics Resource for the Orchid Family Plant & Cell Physiol DOI:10.1093/pcp/pcw220

Choun-Sea Lin, Jeremy JW Chen, Chi-Chou Chiu, Han C.W. Hsiao, Chen-Jui Yang, Xiao-Hua Jin, James Leebens-Mack, Claude W. dePamphilis ,Yao-Ting Huang, Ling-Hung Yang, Wan-Jung Chang, Ling Kui, Gane Ka-Shu Wong, Jer-Ming Hu, Wen Wang, Ming-Che Shih (2017) Concomitant loss of NDH complex-related genes within chloroplast and nuclear genomes in some orchids. The Plant Journal. DOI: 10.1111/tpj.13525

The manuscript describes the first thorough exploration of gallium exposure in the model plant Arabidopsis. Gallium, a rare element, is one of the major elements in semiconductor compounds that are used in integrated circuits and optoelectronic devices. As one of major producers of semiconductor in the world, Hsinchu and Taichung Science Parks in Taiwan has been contaminated with gallium. The contamination of gallium in soil and water may lead to its uptake by plants and accumulation of gallium in the food chain. To our best knowledge, the harmful effects of gallium in plants are not yet investigated. Therefore, we investigated the accumulation, possible toxicity and defense systems of gallium exposure in plants. We found high similarities of exposure effects between gallium and aluminum. ...more
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