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Maria Karmella Apaya, Meng-Ting Chang, and Lie-Fen Shyur* (2016) Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics.Pharmacology & Therapeutics 162:58-68
Integrative approaches in cancer therapy have recently been extended beyond the induction of cytotoxicity to controlling the tumor microenvironment and modulating inflammatory cascades and pathways such as lipid mediator biosynthesis and their dynamics. Profiling of important lipid messengers, such as oxylipins, produced as part of the physiological response to pharmacological stimuli, provides a unique opportunity to explore drug pharmacology and the possibilities for molecular management of cancer physiopathology. Whereas single targeted chemotherapeutic drugs commonly lack efficacy and invoke drug resistance and/or adverse effects in cancer patients, traditional herbal medicines are seen as bright prospects for treating complex diseases, such as cancers, in a systematic and holistic manner. Understanding the molecular mechanisms of traditional medicine and its bioactive chemical constituents may aid the modernization of herbal remedies and the discovery of novel phytoagents for cancer management. In this review, systems-based polypharmacology and studies to develop multi-target drugs or leads from phytomedicines and their derived natural products that may overcome the problems of current anti-cancer drugs, are proposed and summarized. link

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*2017/07/10 10:30 AM
Dr. Wen-Chin Yang (Associate Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica)
Coming Back to Nature:
1. Research and Development of Phytogenics for Animal Health
2. Target Identification and Mechanistic Study of Phytochemicals for Human Health

Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

*2017/07/12 3:30 PM
Dr. Masayoshi Nakamura (Designated Lecturer, Frommer Group, Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Japan)
Mechanisms for Reorientation of Cortical Microtubule Arrays in Response to Blue Light
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

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Kyoko Nakagawa-Goto*, Jo-Yu Chen, Yu-Ting Cheng, Wai-Leng Lee, Munehisa Takeya, Yohei Saito, Kuo-Hsiung Lee*, and Lie-Fen Shyur* (2016) Novel sesquiterpene lactone analogues as potent anti-breast cancer agents. Molecular Oncology, 2016, 10(6):921-937

Choun-Sea Lin, Jeremy JW Chen, Chi-Chou Chiu, Han C.W. Hsiao, Chen-Jui Yang, Xiao-Hua Jin, James Leebens-Mack, Claude W. dePamphilis ,Yao-Ting Huang, Ling-Hung Yang, Wan-Jung Chang, Ling Kui, Gane Ka-Shu Wong, Jer-Ming Hu, Wen Wang, Ming-Che Shih (2017) Concomitant loss of NDH complex-related genes within chloroplast and nuclear genomes in some orchids. The Plant Journal. DOI: 10.1111/tpj.13525

Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, and Lie-Fen Shyur* (2016) A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice. Molecular Cancer Therapeutics, 15(6):1163-1176

H.-F. Chang, S.-L. Wang and K.-C. Yeh* (2017) Effect of gallium exposure in Arabidopsis thaliana is similar to aluminum stress. Environmental Science & Technology: Accepted DOI: 10.1021/acs.est.6b05760

Ya-Ting Chao, Shao-Hua Yen, Jen-Hau Yeh, Wan-Chieh Chen, Ming-Che Shih*(2017) Orchidstra 2.0—A Transcriptomics Resource for the Orchid Family Plant & Cell Physiol DOI:10.1093/pcp/pcw220

Triple-negative breast cancer (TNBC) is associated with high grade, metastatic phenotype, younger patient age, and poor prognosis. The discovery of an effective anti-TNBC agent has been a challenge in oncology. In this study, fifty-eight ester derivatives (DETDs) with a novel sesquiterpene dilactone skeleton were organically synthesized from a bioactive natural product deoxyelephantopin (DET). Among them, DETD-35 showed potent antiproliferative activities against a panel of breast cancer cell lines including TNBC cell line MDA-MB-231, without inhibiting normal mammary cells M10. DETD-35 exhibited a better effect than parental DET on inhibiting migration, invasion, and motility of MDA-MB-231 cells in a concentration-dependent manner. ...more
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