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Ming-Jung Liu*, Koichi Sugimoto, Sahra Uygun, Nicholas Panchy, Michael S. Campbell, Mark Yandell, Gregg A. Howe and Shin-Han Shiu* (2018). Regulatory divergence in wound-responsive gene expression between domesticated and wild tomato. Plant Cell DOI: http://www.plantcell.org/content/early/2018/05/09/tpc.18.00194
Background: Two related species accumulate differences between each other over time. If one of the species is domesticated due to human selection of desirable traits, the domesticated species experiences a "bottleneck" where many traits present in the related wild species are lost because only a few individuals are targeted for selection. For example, domesticated tomato has a weaker defense response to wounding and insect feeding compared to wild tomato species that separated from the domesticated tomato ~3-7 million years ago. One of the major reasons for this difference lies with genes that are turned on and off differently due to evolution of short DNA sequences that are like molecular switches.

Question: We wanted to know how wounding leads to different genes being turned on and off in domesticated and wild tomatoes, which DNA sequence "switches" are important for this response, and how these sequence switches differ between species.

Findings: We found that thousands of genes were turned on or off differently in response to wounding between domesticated and wild tomato species. We found hundreds of potential DNA switches associated with this set of genes, and nearly half of them were unique to one species or the other. Our findings indicate a large difference in how these two plant species turn genes on/off in response to wounding; for example this difference is much greater than similar comparisons between human and mouse genes, which were separated from a common ancestor roughly 100 million years ago. link

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2018/06/11 ABRC Seminar

2018/05/08 ABRC Seminar The 11<sup>th</sup> Tsungming Tu Award Ceremony 2017/04/23 ABRC Seminar

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*2018/08/22 10:30 AM
Dr. Nathaniel Robert Street (Associate Professor, Department of Plant Physiology, Umeå University, Sweden)
Systems genetics and genomics insights into complex traits in aspen and Norway spruce
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

*2018/09/03 10:30 AM
Dr. Sophie A. Lelièvre (Professor of Basic Medical Sciences with courtesy appointment in Nutrition Science; coleader, Drug Discovery & Molecular Sensing NCI-designated Purdue Center for Cancer Research; Scientific Director, 3D Cell Culture Core (3D3C) Facility, Birck Nanotechnology Center, Discovery Park, Purdue University, USA)
Environmental Epigenetics for the Primary Prevention of Cancer
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

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ADMINISTRATIVE RESOURCES


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Triple negative breast cancer (TNBC) is a highly metastatic cancer among the breast cancer subgroups. A thorny issue for clinical therapy of TNBC is lack of an efficient targeted therapeutic strategy. We previously created a novel sesquiterpene lactone analog (named DETD-35) derived from plant deoxyelephantopin (DET) which exhibits potent effects against human TNBC MDA-MB-231 tumor growth in a xenograft mouse model. ...more
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