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Chin-Hsien Tsai, Sheue-Fen Tzeng, Shih-Chuan Hsieh, Yu-Chih Yang, Yi-Wen Hsiao, Mong-Hsun Tsai, and Pei-Wen Hsiao (2017) A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer. Scientific Reports 2017 Nov; 7: 15624
Docetaxel remains the standard treatment for castration-resistant prostate cancer by improving overall survival but having severe adverse toxicity. Inflammatory cytokines in the tumor microenvironment promote docetaxel resistance through activation of IKKα/β-NFκB pathways. To tackle such chemotherapy-elicited adverse effects, this study demonstrates the standardized Wedelia chinensis herbal extract effectively inhibited the production of tumor-promoting cytokines, therefore inhibiting angiogenesis, tumor growth, and metastasis. Transcriptomic analysis of tumors revealed that WCE modulates inflammatory tumor microenvironment by suppressing the expression of HIF1α, IKKα/β phosphorylation and the downstream cytokines/chemokines, e.g., IL6, CXCL1, and CXCL8, thus reduced tumor-elicited chemotaxis and infiltration of MDSCs, TAMs, and endothelial cells into the tumors. Furthermore, WCE suppresses the expansion and activity of MDSCs by downregulating STAT3 activity and also prevents the differentiation of macrophages toward tumor-promoting M2 phenotype. On the other hand, co-treatment of docetaxel with this botanical preparation caused significant enhancement of the docetaxel-mediated therapeutic efficacy, while prevented the drug resistance and toxicity. link

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2018/05/08 ABRC Seminar

The 11<sup>th</sup> Tsungming Tu Award Ceremony 2017/04/23 ABRC Seminar 2017/04/16 ABRC Seminar

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*2018/05/28 10:30 AM
Dr. Shuang Wu (Professor, Horticultural Plant Biology and Metabolomics Center, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, China)
Regulatory network behind endodermal differentiation in plants
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

*2018/06/11 10:30 AM
Dr. David Haak (Assistant Professor of Plant Genomics, Department of Plant Pathology, Physiology, & Weed Science, Virginia Polytechnic Institute and State University, USA)
Comparative genomics of plant defense in wild tomatoes
Auditorium A134, Agricultural Technology Building, Agricultural Biotechnology Research Center

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Sakthivel Kailasam, Ying Wang, Jing-Chi Lo, Hsin-Fang Chang and Kuo-Chen Yeh* (2018) S-nitrosoglutathione works downstream of nitric oxide to mediate iron deficiency signaling in Arabidopsis The Plant Journal, DOI: 10.1111/tpj.13850

Chin-Hsien Tsai, Sheue-Fen Tzeng, Shih-Chuan Hsieh, Chia-Jui Tsai, Yu-Chih Yang, Mong-Hsun Tsai and Pei-Wen Hsiao (2017) A Standardized Wedelia chinensis Extract Overcomes the Feedback Activation of HER2/3 Signaling upon Androgen-Ablation in Prostate Cancer. Frontiers in Pharmacology 2017 Oct; 8:721

Jeng-Yuan Shiau, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, and Lie-Fen Shyur* (2017) Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death. Oncotarget, 2017, 8:56942-56958

Cindy Ast, Jessica Foret, Luke M. Oltrogge, Roberto De Michele, Thomas J. Kleist, Cheng-Hsun Ho & Wolf B. Frommer (2017) Ratiometric Matryoshka biosensors from a nested cassette of green- and orange-emitting fluorescent proteins.Nature Communications(2017), doi:10.1038/s41467-017-00400-2

Choun-Sea Lin*,Chen-Tran Hsu, Ling-Hung Yang, Lan-Ying Lee, Jin-Yuan Fu, Qiao-Wei Cheng, Fu-Hui Wu, Han Chen-Wei Hsiao, Yesheng Zhang, Ru Zhang, Wan-Jung Chang, Chen-Ting Yu, Wen Wang, Li-Jen Liao, Stanton B. Gelvin*,Ming-Che Shih*. (2018) Application of protoplast technology to CRISPR/Cas9 mutagenesis: From single cell mutation detection to mutant plant regeneration. Plant Biotechnol J. 2017 Dec 12. doi: 10.1111/pbi.12870

Several studies elucidated the transcriptional responses to iron (Fe) starvation, however, the Fe sensing and signal transduction machineries are poorly resolved thus far in plants. With this focus, by using chemical biology approach, we identified a small molecule R7, whose use inhibited the physiological and molecular responses of Fe starvation in Arabidopsis. . ...more
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