網站分析程式 徐麗芬
   中央研究院農業生物科技研究中心 研究方向 | 近期著作 | 專利 | 實驗室成員
徐麗芬
徐麗芬
研究員
12/2008- to date Director/Coordinator of Molecular and Biological Agricultural Sciences program of Taiwan International Graduate Program (TIGP-MBAS), Academia Sinica
03/2008- to date Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
04/2008- to date Vice Director, Agricultural Biotechnology Research Center, Academia Sinica
07/2008- to date Adjunct Professor, Institute of Microbiology and Biochemistry, National Taiwan University
2003-2008 Associate Research Fellow, Agricultural Biotechnology Research Center, Academia Sinica
1998-2003 Assistant Research Fellow, Institute of BioAgricultural Sciences, Academia Sinica
1994-1997 Postdoctoral Research Fellow, Department of Biochemistry and Biophysics, Iowa State University, USA
1991-1992 Postdoctoral Research Fellow, Department of Agricultural Chemistry, National Taiwan University
1990-1991 Postdoctoral Research Fellow, Department of Biochemistry, Chang Gung University

辦公室:農科大樓 A731     電話:(02) 2787-2102    
E-mail:lfshyur@ccvax.sinica.edu.tw, jaclyn@gate.sinica.edu.tw
       

近期著作

  1. Apaya, M. K., Lin, C.-Y., Chiou, C.-Y., Yang, C.-C., Ting, C.-Y., and Shyur, L.-F.* (2016) Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway. Molecular Medicine (in press)
  2. Liu, W.-C., Maestre-Reyna, M., Jeng, W.-Y., Lee, C.-C., Hsu, C.-A., Wen, T.-N., Wang, A. H.-J.*, and Shyur, L.-F.* (2015) Structural and functional roles of glycosylation in fungal laccase from Lentinus sp. PLoS ONE (DOI:10.1371/journal.pone.0120601)
  3. Shiau, J.-Y., Yin, S.-Y., Chang, S.-L., Hsu, Y.-J., Chen, K.-W., Kuo, T.-F., Feng, C.-S., Yang, N.-S., Shyur, L.-F.*, Yang, W.-C.*, and Wen, T.-N.* (2015) Mechanistic study of the phytocompound, 2-β-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in human T-Cell acute lymphocytic leukemia cells by using combined differential proteomics and bioinformatics approaches. eCAM Volume 2015, Article ID 475610, 10 pages.
  4. Cheng, Y.-B., Lo, I-W., Shyur, L.-F., Yang, C.-C., Hsu, Y.-Mi., Su, J.-H., Lu, M.-C., Chiou, S.-F., Lan, C.-C., Wu, Y.-C., Chang, F.-R. (2015) New alkaloids from Formosan zoanthid Zoanthus kuroshio. Tetrahedron 71, 8601-8606
  5. Wei, W.-C., Liu, C.-P., Yang, W.-C., Shyur, L.-F., Sheu, J.-H., Chen, S.-S., and Yang, N.-S. (2015) Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells. Journal of Leukocyte Biology (DOI:10.1189/jlb.2A0414-206RR)
  6. Deng, Y.-T., Lin-Shiau, S.-Y. Shyur, L.-F., and Lin, J.-K.* (2015) Pu-erh tea polysaccharides decrease blood sugar by inhibition α-glucosidase activities in vitro and in mice. Food & Function (DOI: 10.1039/C4FO01025F)
  7. Chou#, T.-W., Feng#, J.-H., Huang, C.-C., Cheng, Y.-W., Chien, S.-C., Wang, S.-Y.*, and Shyur, L.-F.* (2013) A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice. PLOS ONE 8, e77626.
  8. Liao, G.-S., Apaya, M. K., and Shyur, L.-F.* (2013) Herbal medicine and acupuncture for breast cancer palliative care and adjuvant therapy. (review article) eCAM Volume 2013, Article ID 437948, 17 pages.
  9. Huang, C.-C., Lin, K.-J., Cheng, Y.-W., Hsu, C.-A., Yang, S.-S., and Shyur, L.-F.* (2013) Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis. Journal of Nutritional Biochemistry 24, 516-530.
  10. Chen, S.-C., Wu, P.-H., Su, Y.-C., Wen, T.-N., Wei, Y.-S., Wang, N.-C., Hsu, C.-A., Wang, Andrew H.-J., and Shyur, L.-F.* (2012) Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1. Protein Engineering Design Selection 25, 761-769.
  11. Liu, W.-C., Lin, Y.-S., Jeng, W.-Y., Chen, J.-H., Wang, A. H.-J., and Shyur, L.-F.* (2012) Engineering of dual functional hybrid glucanases. Protein Engineering Design Selection 25, 771-780. Ho, B.-Y., Lin, C.-H., Apaya, M. K., Chao, W.-W., and Shyur, L.-F.* (2012) Silibinin and paclitaxel synergistically suppress lung metastasis of triple negative 4T1 mammary tumor in mice. Journal of Traditional and Complementary Medicine 2, 301-311.
  12. Hung, S.-W.,Chiu, C.-F., Chen, T.-A., Chu, C.-L., Huang, C.-C., Shyur, L.-F., Liang, C.-M., and Liang, S.-M.* (2012) Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer. Breast Cancer Research and Treatment 136, 89-105.
  13. Lee, W.-L., Shiau, J.-Y., and Shyur, L.-F.* (2012) Taxol, camptothecin and beyond for cancer therapy. Advances in Botanical Research 62, 133-178.
  14. Lee, W.-L. and Shyur, L.-F.* (2012) Deoxyelephantopin impedes mammary adenocarcinoma cell motility through inhibiting calpain-mediated adhesion dynamics and inducing ROS and aggresome formation. Free Radical Biology Medicine 52, 1423-1436.
  15. Hsu, C.-A., Wen, T.-N., Su, Y.-C., Jiang, Z.-B., Chen, C.-W., and Shyur, L.-F.* (2012) Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp. Environmental Science and Technology 46, 5109-5117.
  16. Hou, C.-C., Huang, C.-C., and Shyur, L.-F.* (2011) Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute hepatic injury through JNK pathway-mediated HO-1 expression. Journal of Agricultural and Food Chemistry 59, 11966-11974.
  17. Shyur, L.-F.*, Huang, C.-C., Hsu, Y.-Y., Cheng, Y.-W., and Yang, S.-D. (2011) A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression. Phytochemistry 72, 391-399.
  18. Su, P.-F., Li, C.-J., Hsu, C.-C., Benson, S., Wang, S.-Y., Chan, S. I., Wu, S.-H., Huang, W.-C., Shyur, L.-F.*, and Yang, N.-S.* (2011) Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo. eCAM 2011, 731308. doi:10.1093/ecam/neq032.
  19. Wen, C.-C.#, Shyur, L.-F.#, Jan, J.-T.#, Liang, P.-H., Kuo, C.-J., Arulselvan, P., Wu, J.-B., Kuo, S.-C., and Yang, N.-S. (2011) Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication. Journal of Traditional and Complementary Medicine 1, 41-50. (#: Co-first author)
Print
  1. Jeng, W.-Y., Wang, N.-C., Lin, C.-T., Shyur, L.-F., and Wang, A. H.-J.* (2011) Crystal structures of the laminarinase catalytic domain from Thermotoga maritima MSB8 in complex with inhibitors: essential residues for β-1,3 and β-1,4 glucan selection. Journal of Biological Chemistry 286, 45030-45040.
  2. Tsai, L.-C.*, Hsiao, C.-H., Liu, W.-Y., Yin, L.-M., and Shyur, L.-F. (2011) Structural basis for the inhibition of 1,3-1,4-b-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors. Biochemical and Biophysical Research Communication 407, 593-598.
  3. Lee, W.-L., Wen, T.-N., Shiau, J.-Y., and Shyur, L.-F.* (2010) Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells. Journal of Proteome Research 9, 237-253.
  4. Huang, C.-C., Lo, C.-P., Chiu, C.-Y., and Shyur, L.-F.* (2010) Deoxyelephantopin, a novel multifunctional agent suppresses mammary tumor growth and lung metastasis and doubles survival time in mice. British Journal of Pharmacology 159, 856-871.
  5. Hou, C.-C., Chen, C.-H., Yang, N.-S., Lo, C.-P., Wang, S.-Y., Tien, Y.-J., Tsai, P.-W., and Shyur, L.-F.* (2010) Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants. Journal of Nutritional Biochemistry 21, 1045-1059.
  6. Hsan, K. M., Chen, C.-C., and Shyur, L.-F.* (2010) Current research and development of chemotherapeutic agents for melanoma (review article). Cancers 2, 397-419.
  7. Chen, J.-H., Tsai, L.-C., Huang, H.-C., and Shyur, L.-F.* (2010) Structural and catalytic roles of amino acid residues located at substrate binding pocket in Fibrobacter succinogenes 1,3-1,4-b-D-glucanase. PROTEINS: Structure, Function, and Bioinformatics 78, 2820-2830.
  8. Shyur, L.-F.*, Lee, S.-H., Chang, S.-T., Lo, C.-P., Kuo, Y.-H., and Wang, S.-Y. (2010) Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways. Phytomedicine 18, 16-24.
  9. Lin, Y.-S., Tsai, L.-C., Lee, S.-H., Yuan, H. S., and Shyur, L.-F.* (2009) Structural and catalytic roles of residues located in b13 strand and the following b–turn loop in Fibrobacter succinogenes 1,3-1,4-b-D-glucanase. BBA - GENERAL SUBJECTS 1790, 231-239.
  10. Shyur, L.-F.* and Yang, N.-S.* (2008) Metabolomics for phytomedicine research and drug development. Current Opinions in Chemical Biology 12, 66-71.
  11. Shyur, L.-F.*, Huang, C.-C., Lo, C.-P., Chiu, C.-Y., Chen, Y.-P., Wang, S.-Y., and Chang, S.-T. (2008) Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators. Phytochemistry 69, 1348-1358.
  12. Wu, J.-H., Tung, Y.-T., Chien, S.-C., Wang, S.-Y., Kuo, Y.-H., Shyur, L.-F.*, and Chang, S.-T.* (2008) Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production. Journal of Agricultural and Food Chemistry 56, 1567-1573.
  13. Wang, C.-Y., Staniforth, V., Chiao, M.-T., Hou, C.-C., Wu, H.-M., Yeh, K.-C., Chen, C.-H., Hwang, P.-I., Wen, T.-N., Shyur, L.-F.*, and Yang, N.-S.* (2008) Genomics and proteomics of immune modulatory effects of a butanol fractionof Echinacea purpurea in human dendritic cells. BMC Genomics 9, 479-498.
  14. Tsai, L.-C.*, Huang, H.-C., Hsiao, C.-H., Chiang, Y.-N., Shyur, L.-F.*, Lin, Y.-S., and Lee, S.-H. (2008) Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes 1,3–1,4-β-D-glucanase. Acta Crystallographica Section D D64, 1259–1266.
  15. Tsai, L.-C.*, Chen, Y.-N., and Shyur, L.-F. (2008) Structural modeling of glucanase-substrate complexes reveals residue Tyr177 in barley 1,3-1,4-b-D-glucanase plays an important role in carbohydrate recognition. Journal of Computer-Aided Molecular Design 22, 915-923.
  16. Hou, C.-C., Chen, Y.-P., Wu, J.-H., Huang, C.-C., Wang, S.-Y., Yang, N.-S., and Shyur, L.-F.* (2007) A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma. Cancer Research 67, 6907-6915.
  17. Wen, C.-C., Kuo, Y.-H., Jan, J.-T., Liang, P.-H., Wang, S.-Y., Liu, H.-G., Lee, C.-K., Chang, S.-T., Kuo, C.-J., Lee, S.-S., Hou, C.-C., Hsiao, P.-W., Chien, S.-C., Shyur, L.-F.*, and Yang, N.-S.* (2007) Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of Medicinal Chemistry 50, 4087-4095.
  18. Wu, L.-W., Chiang, Y.-M., Chuang, H.-C., Lo, C.-P., Yang, K.-Y., Wang, S.-Y., and Shyur, L.-F.* (2007) A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7. Planta Medica 73, 655-661.
  19. Chiang, Y.-M., Chang, Cicero L.-T., Chang, S.-L., Yang, W.-C.*, and Shyur, L.-F.* (2007) Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. Journal of Ethnopharmacology 110, 532-538.